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verdinexor 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| nuclear export inhibitors | 5653 | 1392136-43-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A selective inhibitor of nuclear export
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 3.971 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 1.072 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 38.637 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 9.661 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 2.360 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 3.920 | % | High | 1 |
| herg | hERG pIC50 | 4.793 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 7.278 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 8.590 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 1.220 | % | High | 1 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 3.589 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 32.137 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 2.180 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 2.483 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 1 | |||
| pppb | Pig plasma protein binding (% unbound) | 3.320 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 18.072 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 13.900 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 1.560 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 2.911 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| LAVERDIA-CA1 | Anivive Lifesciences Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Exportin-1 | Nuclear other | INHIBITOR | EC50 | 7.62 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| CHEBI:755503 | CHEBI |
| CHEMBL3545187 | ChEMBL_ID |
| C000593855 | MESH_SUPPLEMENTAL_RECORD_UI |
| 14273 | IUPHAR_LIGAND_ID |
| DB12207 | DRUGBANK_ID |
| C4045487 | UMLSCUI |
| 9873 | INN_ID |
| D11223 | KEGG_DRUG |
| 71492799 | PUBCHEM_CID |
| 020352 | NDDF |
| 85Q03215IW | UNII |
| 2539289 | RXNORM |
| 85Q03215IW | INXIGHT DRUGS |
Pharmaceutical products:
None