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potassium bromide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5650 | 7758-02-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FGFR1,FLT3,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,KDR,MAP2K6,MAP3K1,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2,ZAP70 | 73 | |||
| kinase-selectivity-class | GRK2 | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Petit mal epilepsy | 58.01 | 26.38 | 13 | 1006 | 4945 | 90622483 |
| Bromoderma | 33.81 | 26.38 | 4 | 1015 | 24 | 90627404 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Status epilepticus | 69.39 | 31.81 | 24 | 1357 | 15554 | 42604400 |
| Developmental delay | 40.52 | 31.81 | 11 | 1370 | 3171 | 42616783 |
| Somnolence | 35.11 | 31.81 | 32 | 1349 | 141073 | 42478881 |
| Ataxia | 32.62 | 31.81 | 14 | 1367 | 16111 | 42603843 |
| Myoclonic epilepsy | 32.03 | 31.81 | 8 | 1373 | 1666 | 42618288 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Somnolence | 57.87 | 26.55 | 47 | 2092 | 297402 | 110289758 |
| Petit mal epilepsy | 54.68 | 26.55 | 15 | 2124 | 7532 | 110579628 |
| Developmental delay | 54.63 | 26.55 | 11 | 2128 | 1454 | 110585706 |
| Status epilepticus | 54.00 | 26.55 | 21 | 2118 | 31550 | 110555610 |
| Prescribed underdose | 39.42 | 26.55 | 21 | 2118 | 65153 | 110522007 |
| Ataxia | 34.36 | 26.55 | 15 | 2124 | 30093 | 110557067 |
| Myoclonic epilepsy | 32.35 | 26.55 | 8 | 2131 | 2683 | 110584477 |
| Multiple-drug resistance | 30.65 | 26.55 | 11 | 2128 | 13224 | 110573936 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| KBroVet-CA1 | Pegasus Laboratories Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 4 | Enzyme | Ki | 4.05 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:32030 | CHEBI |
| CHEMBL1644030 | ChEMBL_ID |
| C039004 | MESH_SUPPLEMENTAL_RECORD_UI |
| 35903003 | SNOMEDCT_US |
| 421196003 | SNOMEDCT_US |
| C0071754 | UMLSCUI |
| K | PDB_CHEM_ID |
| DB01345 | DRUGBANK_ID |
| DB06715 | DRUGBANK_ID |
| 7758-02-3 | SECONDARY_CAS_RN |
| D01731 | KEGG_DRUG |
| 253877 | PUBCHEM_CID |
| NOCODE | MMSL |
| 005010 | NDDF |
| OSD78555ZM | UNII |
| 34299 | RXNORM |
Pharmaceutical products:
None