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tylvalosin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5643 | 63409-12-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 2.371 | Moderate | 0.65 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 6.966 | Moderate | 0.65 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 28.774 | 10^-6 cm/s | Moderate | 0.65 |
| dh-clint | Dog hepatocyte intrinsic clearance | 26.607 | uL/min/10^6 cells | Moderate | 0.65 |
| dppb | Dog plasma protein binding (% unbound) | 30.340 | % | Moderate | 0.65 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 31.970 | % | Moderate | 0.65 |
| herg | hERG pIC50 | 4.576 | pIC50 | Moderate | 0.65 |
| hh-clint | Human hepatocyte intrinsic clearance | 18.493 | uL/min/10^6 cells | Moderate | 0.65 |
| hlm-clint | Human liver microsomal intrinsic clearance | 141.906 | uL/min/mg protein | Moderate | 0.65 |
| hppb | Human plasma protein binding (% unbound) | 32.770 | % | Moderate | 0.65 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 11.298 | Moderate | 0.65 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 43.752 | Moderate | 0.65 | |
| mppb | Mouse plasma protein binding (% unbound) | 22.910 | Moderate | 0.65 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 24.322 | Moderate | 0.65 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 34.370 | % | Moderate | 0.65 |
| rh-clint | Rat hepatocyte intrinsic clearance | 46.989 | uL/min/10^6 cells | Moderate | 0.65 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 71.850 | % | Moderate | 0.65 |
| rppb | Rat plasma protein binding (% unbound) | 25.700 | % | Moderate | 0.65 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 716.143 | uM | Moderate | 0.65 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Swine | Proliferative enteropathy (PPE) associated with Lawsonia intracellularis infection | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Aivlosin | ECO LLC | 1 |
| Aivlosin 17% | ECO LLC | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| CHEBI:750489 | CHEBI |
| CHEMBL2103834 | ChEMBL_ID |
| C545430 | MESH_SUPPLEMENTAL_RECORD_UI |
| 13706 | IUPHAR_LIGAND_ID |
| DB11554 | DRUGBANK_ID |
| C2744563 | UMLSCUI |
| CHEMBL2105658 | ChEMBL_ID |
| 8533 | INN_ID |
| 63428-13-7 | SECONDARY_CAS_RN |
| D10032 | KEGG_DRUG |
| 6441094 | PUBCHEM_CID |
| 9T02S42WQO | UNII |
| 1368468 | RXNORM |
Pharmaceutical products:
None