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toluene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5635 | 108-88-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,MAP3K1,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,TEK,TTK | 43 | |||
| kinase-selectivity-class | ACVR2B,AXL,ERBB2,GRK2,PDK4,SIK2,SIK3 | 7 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D012997 | Solvents |
| CHEBI has role | CHEBI:48355 | non-polar solvent |
| CHEBI has role | CHEBI:48873 | cholinergic antagonist |
| CHEBI has role | CHEBI:50910 | neurotoxin |
| CHEBI has role | CHEBI:62803 | fuel additive |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Removal of ascarids, Toxocara canis | Indication |
| Cats | Removal of ascarids, Toxascaris leonina | Indication |
| Cats | Removal of hookworms, Ancylostoma caninum | Indication |
| Cats | Removal of hookworms, Uncinaria stenocephala | Indication |
| Cats | Removing of tapeworms, Taenia pisiformis | Indication |
| Cats | Removing of tapeworms, Dipylidium caninum | Indication |
| Cats | Removing of tapeworms, Echinococcus granulosus | Indication |
| Dogs | Removal of ascarids, Toxocara canis | Indication |
| Dogs | Removal of ascarids, Toxascaris leonina | Indication |
| Dogs | Removal of hookworms, Ancylostoma caninum | Indication |
| Dogs | Removal of hookworms, Uncinaria stenocephala | Indication |
| Dogs | Removing of tapeworms, Taenia pisiformis | Indication |
| Dogs | Removing of tapeworms, Dipylidium caninum | Indication |
| Dogs | Removing of tapeworms, Echinococcus granulosus | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Vermiplex | Intervet Inc. | 2 |
| Anaplex Caps, Canine and Feline Wormer Caps | Cronus Pharma Specialities India Private Limited | 2 |
| Difolin No. 1 Capsules, Difolin No. 2.5 Capsules, Difolin No. 25 Capsules, Difolin No. 40 Capsules, Difolin No. 5 Capsules | Zoetis Inc. | 2 |
| Tri-Plex Worm Capsules | Intervet Inc. | 2 |
| Trivermicide Worm Capsules | Happy Jack Inc. | 2 |
| Worm Capsules | Farnam Companies Inc. | 2 |
| D & T Worm Capsules | Cronus Pharma Specialities India Private Limited | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | Enzyme | IC50 | 8.28 | CHEMBL | |||||
| Endolysin | Enzyme | Kd | 4.15 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:17578 | CHEBI |
| MBN | PDB_CHEM_ID |
| CHEMBL9113 | ChEMBL_ID |
| 5481 | IUPHAR_LIGAND_ID |
| DB11558 | DRUGBANK_ID |
| C0040383 | UMLSCUI |
| D014050 | MESH_DESCRIPTOR_UI |
| C01455 | KEGG_DRUG |
| 1140 | PUBCHEM_CID |
| NOCODE | MMSL |
| 002481 | NDDF |
| 3FPU23BG52 | UNII |
| 1311381 | RXNORM |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Deluqing | HUMAN OTC DRUG LABEL | 18 | 82570-015 | POWDER | 6 g | TOPICAL | unapproved drug other | 8 sections |