DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
phenothiazine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
5597
92-84-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
phenothiazine
NSC-2037
Molecular weight: 199.27
Formula: C12H9NS
CLOGP: 3.91
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 12.03
ALOGS: -2.71
ROTB: 0
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
None
FDA
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Completed suicide
133.52
86.40
37
144
145636
63343205
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Completed suicide
112.04
52.42
43
368
245724
79498253
Cardio-respiratory arrest
56.22
52.42
21
390
108489
79635488
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
CHEBI has role
CHEBI:48578
free radical scavengers
CHEBI has role
CHEBI:76924
plant metabolites
CHEBI has role
CHEBI:173084
ferroptosis inhibitors
MeSH PA
D000890
Anti-Infective Agents
MeSH PA
D000977
Antiparasitic Agents
MeSH PA
D000981
Antiprotozoal Agents
Showing 1 to 6 of 6 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
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Species
Use
Relation
Horses
Removal of bots, Gastrophilus nasalis
Indication
Horses
Removal of bots, Gastrophilus intestinalis
Indication
Horses
Removal of large strongyles, Strongylus vulgaris
Indication
Horses
Removal of small strongyles
Indication
Horses
Removal of large roundworms, Parascaris equorum
Indication
Horses
Removal of pinworms, Oxyuris equi
Indication
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🐶 Veterinary products
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Product
Applicant
Ingredients
Dyrex T.F - 1000, Dyrex T.F - 200, Dyrex T.F - 500
Zoetis Inc.
3
Parvex Plus Suspension
Zoetis Inc.
2
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Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Prostaglandin G/H synthase 2
Enzyme
P35354
PGH2_HUMAN
IC50
6.27
CHEMBL
Cannabinoid receptor 1
GPCR
P21554
CNR1_HUMAN
Ki
4.71
CHEMBL
Prostaglandin G/H synthase 1
Enzyme
P23219
PGH1_HUMAN
IC50
6.71
CHEMBL
Sodium-dependent noradrenaline transporter
Transporter
P23975
SC6A2_HUMAN
IC50
6.34
CHEMBL
5-hydroxytryptamine receptor 2C
GPCR
P28335
5HT2C_HUMAN
Ki
5.93
CHEMBL
Sodium-dependent dopamine transporter
Transporter
Q01959
SC6A3_HUMAN
Ki
4.83
CHEMBL
Adenosine receptor A3
GPCR
P0DMS8
AA3R_HUMAN
Ki
4.84
CHEMBL
Acetylcholinesterase
Enzyme
P22303
ACES_HUMAN
IC50
5.14
CHEMBL
Cholinesterase
Enzyme
P06276
CHLE_HUMAN
IC50
5.24
CHEMBL
Cytochrome P450 1A2
Enzyme
P05177
CP1A2_HUMAN
IC50
7.80
CHEMBL
Showing 1 to 10 of 14 entries
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External reference:
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ID
Source
372839006
SNOMEDCT_US
4173
INN_ID
7108
PUBCHEM_CID
765430004
SNOMEDCT_US
C0031436
UMLSCUI
C031637
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:37932
CHEBI
CHEMBL828
ChEMBL_ID
D02601
KEGG_DRUG
DB11447
DRUGBANK_ID
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Pharmaceutical products:
None
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phenothiazine