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imidacloprid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5559 | 138261-41-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Systemic contact insecticide exhibiting low mammalian toxicity. This neonicotinoid insecticide acts as an antagonist by binding to postsynaptic nicotinic receptors in the insect central nervous system
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,STK33,TEK,TTK | 24 | |||
| kinase-selectivity-class | AXL,DYRK1B,GRK2,MAPK7,STK33,TEK,TTK | 7 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D010575 | Pesticides |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| CHEBI has role | CHEBI:25540 | neonicotinoid insectide |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:47958 | nicotinic acetylcholine receptor agonist |
| CHEBI has role | CHEBI:50902 | genotoxin |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Ear mite infestations with Otodectes cynotis | Indication |
| Cats | Kills adult fleas | Indication |
| Cats | Flea infestations caused by Ctenocephalides felis | Indication |
| Dogs | Flea infestations | Indication |
| Ferrets | Flea infestations | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Advantage DUO | Elanco US Inc. | 2 |
| Advantage Multi for Dogs | Elanco US Inc. | 2 |
| Advantage Multi for Cats | Elanco US Inc. | 2 |
| advantus | Elanco US Inc. | 1 |
| IMOXI Topical Solution for Dogs | Vetoquinol USA Inc. | 2 |
| IMOXI Topical Solution for Cats | Vetoquinol USA Inc. | 2 |
| PARASEDGE Multi for Dogs | Chanelle Pharmaceuticals Manufacturing Ltd. | 2 |
| PARASEDGE Multi for Cats | Chanelle Pharmaceuticals Manufacturing Ltd. | 2 |
| Barrier for cats | Aurora Pharmaceutical Inc. | 2 |
| Midamox for Dogs | Norbrook Laboratories, Ltd. | 2 |
| Barrier for dogs | Aurora Pharmaceutical Inc. | 2 |
| Midamox for Cats | Norbrook Laboratories, Ltd. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-3 | Ion channel | IC50 | 4.85 | CHEMBL | |||||
| Acetylcholine-binding protein | Secreted | Ki | 6.01 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-4 | Ion channel | Ki | 7.30 | CHEMBL | |||||
| Soluble acetylcholine receptor | Secreted | Ki | 7.72 | CHEMBL | |||||
| Nicotinic acetylcholine receptor alpha 5 subunit | Ion channel | IC50 | 8.59 | CHEMBL | |||||
| Acetylcholine receptor subunit beta-like 2 | Ion channel | IC50 | 8.64 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-4 | Ion channel | Ki | 6.01 | CHEMBL | |||||
| Neuronal acetylcholine receptor subunit alpha-4 | Ion channel | IC50 | 5.58 | CHEMBL | |||||
| Nicotinic acetylcholine receptor alpha8 subunit | Ion channel | EC50 | 5.88 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:5870 | CHEBI |
| IM4 | PDB_CHEM_ID |
| CHEMBL406819 | ChEMBL_ID |
| C082359 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB11421 | DRUGBANK_ID |
| 425652007 | SNOMEDCT_US |
| C0218499 | UMLSCUI |
| C11110 | KEGG_DRUG |
| 86287518 | PUBCHEM_CID |
| 017717 | NDDF |
| 3BN7M937V8 | UNII |
| 1251576 | RXNORM |
Pharmaceutical products:
None