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amprolium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quaternary ammonium compounds | 5557 | 121-25-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A veterinary coccidiostat that interferes with THIAMINE metabolism
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK7,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TTK | 35 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,EIF2AK3,GRK2 | 5 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D000981 | Antiprotozoal Agents |
| MeSH PA | D003049 | Coccidiostats |
| CHEBI has role | CHEBI:35818 | coccidiostat |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cattle | Prevention of coccidiosis caused by Eimeria bovis | Indication |
| Cattle | Prevention of coccidiosis caused by E zurnii | Indication |
| Chickens | Development of active immunity to coccidiosis | Indication |
| Chickens | Prevention of coccidiosis | Indication |
| Pheasants | Prevention of coccidiosis caused by Eimeria colchici | Indication |
| Pheasants | Prevention of coccidiosis caused by E duodenalis | Indication |
| Pheasants | Prevention of coccidiosis caused by E phasiani | Indication |
| Turkeys | Prevention of coccidiosis | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Amprol 25% Type A Medicated Article, Corid Type A Medicated Article | Huvepharma EOOD | 1 |
| Amprovine 9.6% Solution, CORID 9.6% Oral Solution | Huvepharma EOOD | 1 |
| Amprol Hi-E, Amprol Plus | Huvepharma EOOD | 2 |
| Cocciprol | Phibro Animal Health Corp. | 1 |
| AMPROL 128, Corid 20% Soluble Powder | Huvepharma EOOD | 1 |
| Amprol HI-E Plus | Huvepharma EOOD | 3 |
| Amprol Plus and Aureomycin | Zoetis Inc. | 3 |
| Amprol HI-E & Bambermycins, Amprol HI-E / Flavomycin | Huvepharma EOOD | 3 |
| Baciferm / Amprol HI-E Premix | Zoetis Inc. | 3 |
| Flavomycin and Amprol/ Amprol 25% and Flavomycin | Huvepharma EOOD | 2 |
| Amprol / BMD | Zoetis Inc. | 2 |
| Stafac and AMPROL | Phibro Animal Health Corp. | 2 |
| Albac / Amprol Hi-E | Zoetis Inc. | 3 |
| Amprolium 9.6% Oral Solution | Huvepharma EOOD | 1 |
| Amprolium-P 9.6% Oral Solution | Huvepharma EOOD | 1 |
| AMPROMED For Cattle | Bimeda Animal Health Limited | 1 |
| AmproMed for Calves | Bimeda Animal Health Limited | 1 |
| Ampromed P for Poultry | Bimeda Animal Health Limited | 1 |
| AmproMed P for Poultry | Bimeda Animal Health Limited | 1 |
| Boviprol 9.6% Oral Solution | Phibro Animal Health Corp. | 1 |
| CocciAid | Aurora Pharmaceutical Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Thiamine transporter 1 | Transporter | Ki | 5.12 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 137-88-2 | SECONDARY_CAS_RN |
| CHEBI:85265 | CHEBI |
| A1H5C | PDB_CHEM_ID |
| CHEMBL1318296 | ChEMBL_ID |
| DB11374 | DRUGBANK_ID |
| 96146007 | SNOMEDCT_US |
| C0002686 | UMLSCUI |
| D000670 | MESH_DESCRIPTOR_UI |
| D02928 | KEGG_DRUG |
| 73341 | PUBCHEM_CID |
| 95CO6N199Q | UNII |
| 1006654 | RXNORM |
Pharmaceutical products:
None