grapiprant 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prostaglandin receptors antagonists, non-prostanoids 5552 415903-37-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • grapiprant
  • RQ-7
  • RQ-00000007
  • MR10A7
  • AAT-007
  • CJ-023423
A potent and selective prostaglandin EP4 receptor antagonist with antihyperalgesic properties
  • Molecular weight: 491.61
  • Formula: C26H29N5O3S
  • CLOGP: 5.23
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 105.98
  • ALOGS: -4.92
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Pain and inflammation associated with osteoarthritis Indication

🐶 Veterinary products

ProductApplicantIngredients
GALLIPRANT Elanco US Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin E2 receptor EP4 subtype GPCR ANTAGONIST Ki 7.89 IUPHAR
Prostaglandin E2 receptor EP4 subtype GPCR ANTAGONIST Ki 7.89 IUPHAR
Prostaglandin E2 receptor EP4 subtype Unclassified Ki 7.62 CHEMBL
Prostaglandin E2 receptor EP4 subtype GPCR Ki 7.70 CHEMBL

External reference:

IDSource
CHEMBL3039498 ChEMBL_ID
C522837 MESH_SUPPLEMENTAL_RECORD_UI
5858 IUPHAR_LIGAND_ID
DB12836 DRUGBANK_ID
017766 NDDF
C4278621 UMLSCUI
9763 INN_ID
D10638 KEGG_DRUG
11677589 PUBCHEM_CID
1862951 RXNORM
J9F5ZPH7NB UNII

Pharmaceutical products:

None