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florfenicol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibacterial antibiotics, chloramphenicol analogues | 5543 | 73231-34-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 0.568 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 3.656 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 4.842 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 2.897 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 70.630 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 84.540 | % | High | 1 |
| herg | hERG pIC50 | 4.201 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 2.094 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 7.362 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 70.720 | % | High | 1 |
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP2K6,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 | 33 | |||
| kinase-selectivity-class | PDK1,PDK2 | 2 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 2.570 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 27.416 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 73.900 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 11.041 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 75.170 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 31.117 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 96.260 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 62.780 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 816.582 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cattle | Bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica | Indication |
| Cattle | Bovine respiratory disease (BRD) associated with Pasteurella multocida | Indication |
| Cattle | Bovine respiratory disease (BRD) associated with Haemophilus somnus | Indication |
| Cattle | Bovine interdigital phlegmon associated with Fusobacterium necrophorum | Indication |
| Cattle | Bovine interdigital phlegmon associated with Bacteroides melaninogenicus | Indication |
| Fish | Streptococcal septicemia associated with Streptococcus inia | Indication |
| Fish | Control of mortality caused by coldwater disease associated with Flavobacterium psychrophilum | Indication |
| Fish | Furunculosis caused by Aeromonas salmonicida | Indication |
| Fish | Control of mortality caused by columnaris disease associated with Flavobacterium columnare | Indication |
| Fish | Control of mortality caused by enteric septicemia associated with Edwardsiella ictaluri | Indication |
| Swine | Swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae | Indication |
| Swine | Swine respiratory disease (SRD) associated with Pasteurella multocida | Indication |
| Swine | Swine respiratory disease (SRD) associated with Salmonella choleraesuis | Indication |
| Swine | Swine respiratory disease (SRD) associated with Bordetella bronchiseptica | Indication |
| Swine | Swine respiratory disease (SRD) associated with Streptococcus suis | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Nuflor , Nuflor-S | Intervet Inc. | 1 |
| Nuflor Concentrate Solution | Intervet Inc. | 1 |
| Aquaflor Type A Medicated Article | Intervet Inc. | 1 |
| Nuflor | Intervet Inc. | 1 |
| NuflorGOLD | Intervet Inc. | 1 |
| Resflor Gold | Intervet Inc. | 2 |
| Osurnia | Dechra, Ltd. | 3 |
| CLARO | Elanco US Inc. | 3 |
| Florvio 2.3% Concentrate Solution | Elanco US Inc. | 1 |
| Loncor 300 | Elanco US Inc. | 1 |
| FLORFENICOL INJECTION | Sparhawk Laboratories Inc. | 1 |
| FLORCON | Med-Pharmex Inc. | 1 |
| Norfenicol | Norbrook Laboratories, Ltd. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| CHEBI:87185 | CHEBI |
| CHEMBL1241590 | ChEMBL_ID |
| C035534 | MESH_SUPPLEMENTAL_RECORD_UI |
| 12923 | IUPHAR_LIGAND_ID |
| DB11413 | DRUGBANK_ID |
| 426930005 | SNOMEDCT_US |
| 427436003 | SNOMEDCT_US |
| C0060466 | UMLSCUI |
| 5777 | INN_ID |
| D04194 | KEGG_DRUG |
| 114811 | PUBCHEM_CID |
| 017887 | NDDF |
| 9J97307Y1H | UNII |
| 25086 | RXNORM |
Pharmaceutical products:
None