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fenthion 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5541 | 55-38-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Potent cholinesterase inhibitor used as an insecticide and acaricide
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 | 65 | |||
| kinase-selectivity-class | AXL,BRAF,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,MAP2K6,MAPK7,PDK4,PRKDC,SIK2,STK33,SYK,TEK,ZAP70 | 17 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D002800 | Cholinesterase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D010575 | Pesticides |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| CHEBI has role | CHEBI:22153 | acaricide |
| CHEBI has role | CHEBI:24852 | insecticide |
| CHEBI has role | CHEBI:33286 | agrochemical |
| CHEBI has role | CHEBI:33289 | avicide |
| CHEBI has role | CHEBI:37733 | EC 3.1.1.8 (cholinesterase) inhibitor |
| CHEBI has role | CHEBI:38462 | EC 3.1.1.7 (acetylcholinesterase) inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Flea control | Indication |
| Cattle | Control of grubs and lice | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Tiguvon Pour-On Cattle Insecticide | Elanco US Inc. | 1 |
| Spotton 20% Ready-to-Use Cattle Insecticide | Elanco US Inc. | 1 |
| Pro-Spot Solution | Elanco US Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| CHEBI:34761 | CHEBI |
| CHEMBL1604375 | ChEMBL_ID |
| DB11412 | DRUGBANK_ID |
| 96135009 | SNOMEDCT_US |
| C0015848 | UMLSCUI |
| D005284 | MESH_DESCRIPTOR_UI |
| D07950 | KEGG_DRUG |
| 3346 | PUBCHEM_CID |
| BL0L45OVKT | UNII |
| BL0L45OVKT | INXIGHT DRUGS |
Pharmaceutical products:
None