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ethopabate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5536 | 59-06-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An inhibitor of folate metabolism. It is used as coccidiostat in poultry
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPK9,MARK4,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 52 | |||
| kinase-selectivity-class | AXL,DDR1,DYRK1B,GRK2,PDK4,STK33,TEK,TTK | 8 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D000981 | Antiprotozoal Agents |
| MeSH PA | D003049 | Coccidiostats |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Chicken | Prevention of coccidiosis where severe exposure to coccidiosis from E acervulina | Indication |
| Chicken | Prevention of coccidiosis where severe exposure to coccidiosis from E maxima | Indication |
| Chicken | Prevention of coccidiosis where severe exposure to coccidiosis from E brunette | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Amprol Hi-E, Amprol Plus | Huvepharma EOOD | 2 |
| Amprol HI-E Plus | Huvepharma EOOD | 3 |
| Amprol Plus and Aureomycin | Zoetis Inc. | 3 |
| Amprol HI-E & Bambermycins, Amprol HI-E / Flavomycin | Huvepharma EOOD | 3 |
| Baciferm / Amprol HI-E Premix | Zoetis Inc. | 3 |
| Albac / Amprol Hi-E | Zoetis Inc. | 3 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Neuraminidase | Enzyme | IC50 | 6.66 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:183844 | CHEBI |
| CHEMBL458769 | ChEMBL_ID |
| 96147003 | SNOMEDCT_US |
| C0015041 | UMLSCUI |
| D005011 | MESH_DESCRIPTOR_UI |
| D08916 | KEGG_DRUG |
| 6034 | PUBCHEM_CID |
| F4X3L6068O | UNII |
| 1314353 | RXNORM |
Pharmaceutical products:
None