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amitraz 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5535 | 33089-61-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Ixodicide (tick control)
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK | 43 | |||
| kinase-selectivity-class | AXL,BRAF,EIF2AK3,ERBB2,GRK2,PDK4,SIK2 | 7 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:22153 | acaricide |
| CHEBI has role | CHEBI:24852 | insecticide |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
| MeSH PA | D000316 | Adrenergic alpha-Agonists |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D007302 | Insect Repellents |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D010574 | Pesticide Synergists |
| MeSH PA | D010575 | Pesticides |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D058647 | Adrenergic alpha-2 Receptor Agonists |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Generalized demodicosis caused by Demodex canis | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Mitaban Liquid Concentrate | Zoetis Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | GPCR | Ki | 6.46 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:2665 | CHEBI |
| CHEMBL1365675 | ChEMBL_ID |
| C014983 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB11373 | DRUGBANK_ID |
| 96324009 | SNOMEDCT_US |
| C0051692 | UMLSCUI |
| 5183 | INN_ID |
| D02380 | KEGG_DRUG |
| 36324 | PUBCHEM_CID |
| 017739 | NDDF |
| 33IAH5017S | UNII |
| 17763 | RXNORM |
Pharmaceutical products:
None