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enrofloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibacterials, nalidixic acid derivatives | 5532 | 93106-60-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A fluoroquinolone antibacterial and antimycoplasma agent that is used in veterinary practice
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,EIF2AK3,GRK2,PDK1,PDK2,PDK4 | 6 | |||
| kinase-selectivity-class | ACVR2B,AXL,CDK9,DYRK1B,EIF2AK3,GRK2,MAPK7,PDK4,PIK3CB,PRKDC,STK33,TEK,TGFBR1,TTK | 14 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 1.050 | Moderate | 0.77 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| rat-kpuu-brain | Rat brain Kpuu | 0.129 | % | Moderate | 0.77 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Management of diseases associated with bacteria | Indication |
| Cattle | Bovine respiratory disease (BRD) associated with Mannheimia haemolytica | Indication |
| Cattle | Bovine respiratory disease (BRD) associated with Pasteurella multocida | Indication |
| Cattle | Bovine respiratory disease (BRD) associated with Histophilus somni | Indication |
| Cattle | Bovine respiratory disease (BRD) associated with Mycoplasma bovis | Indication |
| Dogs | Otitis externa complicated by bacterial and fungal organisms | Indication |
| Dogs | Diseases associated with bacteria | Indication |
| Swine | Swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae | Indication |
| Swine | Swine respiratory disease (SRD) associated with Pasteurella multocida | Indication |
| Swine | Swine respiratory disease (SRD) associated with Haemophilus parasuis | Indication |
| Swine | Swine respiratory disease (SRD) associated with Streptococcus suis | Indication |
| Swine | Swine respiratory disease (SRD) associated with Bordetella bronchiseptica | Indication |
| Swine | Swine respiratory disease (SRD) associated with Mycoplasma hyopneumoniae | Indication |
| Swine | Colibacillosis associated with Escherichia coli | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Baytril Antibacterial Tablets, Baytril Taste Tabs Antibacterial Tablets | Elanco US Inc. | 1 |
| Baytril Antibacterial Injectable Solution | Elanco US Inc. | 1 |
| Baytril 100 Injectable Solution | Elanco US Inc. | 1 |
| Baytril Otic | Elanco US Inc. | 2 |
| Baytril 100-CA1 | Elanco US Inc. | 1 |
| Enroflox 100 | Norbrook Laboratories, Ltd. | 1 |
| Enroflox Injection for Dogs 2.27% | Norbrook Laboratories, Ltd. | 1 |
| Zobuxa | Elanco US Inc. | 1 |
| Enrofloxacin Antibacterial Injectable Solution | Dechra Veterinary Products LLC | 1 |
| Enrofloxacin Flavored Tablets | Dechra Veterinary Products LLC | 1 |
| EnroMed 100 | Bimeda Animal Health Limited | 1 |
| Baytril Soft Chewable Tablets | Elanco US Inc. | 1 |
| ENROFLOXACIN 100 | Sparhawk Laboratories Inc. | 1 |
| Enrofloxacin Flavored Tablets | Felix Pharmaceuticals Pvt. Ltd. | 1 |
| Tenotryl | Virbac AH Inc. | 1 |
| Enrofloxacin | Accord Healthcare Inc. | 1 |
| Enrofloxacin | Felix Pharmaceuticals Pvt. Ltd. | 1 |
| Enroflox Chewable Tablets | Norbrook Laboratories, Ltd. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| CHEBI:35720 | CHEBI |
| CHEMBL15511 | ChEMBL_ID |
| 13668 | IUPHAR_LIGAND_ID |
| DB11404 | DRUGBANK_ID |
| 702749000 | SNOMEDCT_US |
| 96080008 | SNOMEDCT_US |
| C0059374 | UMLSCUI |
| D000077422 | MESH_DESCRIPTOR_UI |
| 5963 | INN_ID |
| D02473 | KEGG_DRUG |
| 71188 | PUBCHEM_CID |
| 017756 | NDDF |
| 3DX3XEK1BN | UNII |
| 204329 | RXNORM |
Pharmaceutical products:
None