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dichlorvos 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| insecticides, anthelminthics, pesticides etc., phosphorous derivatives | 5523 | 62-73-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 65 | |||
| kinase-selectivity-class | AXL,BRAF,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,IRAK3,JAK2,MAP2K6,MAP3K2,MAPK10,MAPK12,MAPK7,PDK2,PRKDC,STK33,SYK,TEK,TTK,ZAP70 | 23 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D010575 | Pesticides |
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D002800 | Cholinesterase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35443 | anthelminthic drug |
| CHEBI has role | CHEBI:35718 | antifungal agent |
| CHEBI has role | CHEBI:37733 | EC 3.1.1.8 (cholinesterase) inhibitor |
| CHEBI has role | CHEBI:38462 | EC 3.1.1.7 (acetylcholinesterase) inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Removal of intestinal roundworms, Toxocara cati | Indication |
| Cats | Removal of hookworms, Ancylostoma tubaeforme | Indication |
| Cats | Removal of intestinal roundworms, Toxascaris leonina | Indication |
| Cats | Removal of hookworms, Uncinaria stenocephala | Indication |
| Dogs | Removal of Toxocara canis | Indication |
| Dogs | Removal of Toxascaris leonina | Indication |
| Dogs | Removal of Ancylostoma caninum | Indication |
| Dogs | Removal of hookworms, Uncinaria stenocephala | Indication |
| Dogs | Removal of whipworms, Trichuris vulpis | Indication |
| Horses | Removal of bots, Gastrophilus intestinalis | Indication |
| Horses | Removal of large strongyles, Strongylus vulgaris | Indication |
| Horses | Removal of small strongyles | Indication |
| Horses | Removal of large roundworms, Parascaris equorum | Indication |
| Horses | Removal of large strongyles, S equinus | Indication |
| Horses | Removal of large strongyles, S edentatus | Indication |
| Horses | Removal of bots, G nasalis | Indication |
| Swine | Improving litter production efficiency | Indication |
| Swine | Removal of immature and/or fourth stage larvae of whipworms, Trichuris suis | Indication |
| Swine | Removal of nodular worms, Oesophagostomum species | Indication |
| Swine | Removal of large roundworms, Ascaris suum | Indication |
| Swine | Removal of thick stomach worms, Ascarops strongylina | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Atgard Swine Wormer 27 g, Atgard Swine Wormer 5.4g, Atgard V Swine Wormer 27 g, Atgard V Swine Wormer 5.4 g | Cronus Pharma Specialities India Private Limited | 1 |
| Task Dog Anthelmintic | Cronus Pharma Specialities India Private Limited | 1 |
| Equigard, Verdisol | Cronus Pharma Specialities India Private Limited | 1 |
| Atgard C Swine Wormer | Cronus Pharma Specialities India Private Limited | 1 |
| Atgard Swine Wormer, Atgard V Swine Wormer | Cronus Pharma Specialities India Private Limited | 1 |
| Equigel | Cronus Pharma Specialities India Private Limited | 1 |
| Task Tabs | Cronus Pharma Specialities India Private Limited | 1 |
| Atgard C Premix 9.6% | Cronus Pharma Specialities India Private Limited | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase | Enzyme | IC50 | 6.20 | CHEMBL | |||||
| Acetylcholinesterase, AChE, EC 3.1.1.7 | Enzyme | IC50 | 7.22 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:34690 | CHEBI |
| CHEMBL167911 | ChEMBL_ID |
| DB11397 | DRUGBANK_ID |
| 57868002 | SNOMEDCT_US |
| C0012087 | UMLSCUI |
| D004006 | MESH_DESCRIPTOR_UI |
| 3285 | INN_ID |
| D03791 | KEGG_DRUG |
| 3039 | PUBCHEM_CID |
| 7U370BPS14 | UNII |
| 7U370BPS14 | INXIGHT DRUGS |
Pharmaceutical products:
None