upacicalcet 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium-sensing receptors (CaSR) agonists 5482 1333218-50-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • upacicalcet
  • upacicalcet sodium hydrate
  • upasita
Upacicalcet acts directly on parathyroid cell membrane calcium-sensing receptors and it suppresses excessive parathyroid hormone secretion.
  • Molecular weight: 351.76
  • Formula: C11H14ClN3O6S
  • CLOGP: -3.30
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 5
  • TPSA: 158.82
  • ALOGS: -3.11
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 23, 2021 PMDA SANWA KAGAKU KENKYUSHO Co., Ltd.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Secondary hyperparathyroidism indication 91478007 DOID:12466




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Extracellular calcium-sensing receptor GPCR ALLOSTERIC MODULATOR IC50 8.09 IUPHAR SCIENTIFIC LITERATURE

External reference:

IDSource
5C1222PBE2 UNII
C5238141 UMLSCUI
53374467 PUBCHEM_CID
10796 INN_ID
12235 IUPHAR_LIGAND_ID
D11564 KEGG_DRUG
C000721071 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None