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upacicalcet 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| calcium-sensing receptors (CaSR) agonists | 5482 | 1333218-50-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Upacicalcet acts directly on parathyroid cell membrane calcium-sensing receptors and it suppresses excessive parathyroid hormone secretion.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 23, 2021 | PMDA | SANWA KAGAKU KENKYUSHO Co., Ltd. |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:231911 | renoprotective agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Secondary hyperparathyroidism | indication | 91478007 | DOID:12466 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Extracellular calcium-sensing receptor | GPCR | ALLOSTERIC MODULATOR | IC50 | 8.09 | IUPHAR | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| 5C1222PBE2 | UNII |
| C5238141 | UMLSCUI |
| CHEBI:760333 | CHEBI |
| CHEMBL6068421 | ChEMBL_ID |
| 53374467 | PUBCHEM_CID |
| 10796 | INN_ID |
| C000721071 | MESH_SUPPLEMENTAL_RECORD_UI |
| 12235 | IUPHAR_LIGAND_ID |
| D11564 | KEGG_DRUG |
Pharmaceutical products:
None