DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
mefuparib 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
poly-ADP-ribose polymerase inhibitors
5378
None
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
mefuparib
mefuparib hydrochloride
CVL218
Poly(ADP-ribose) Polymerase Inhibitors
Molecular weight: 298.32
Formula: C17H15FN2O2
CLOGP: 2.99
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 68.26
ALOGS: -4.04
ROTB: 4
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
CHEBI has role
CHEBI:35610
antineoplastic agents
CHEBI has role
CHEBI:62913
PARP
CHEBI has role
CHEBI:68495
Type I cell-death inducers
CHEBI has role
CHEBI:149553
anticoronaviral drug
Showing 1 to 4 of 4 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
12.94
acidic
pKa2
9.23
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Poly [ADP-ribose] polymerase 2
Enzyme
Q9UGN5
PARP2_HUMAN
INHIBITOR
IC50
8.72
SCIENTIFIC LITERATURE
Poly [ADP-ribose] polymerase 1
Enzyme
P09874
PARP1_HUMAN
INHIBITOR
IC50
8.49
SCIENTIFIC LITERATURE
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External reference:
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entries
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ID
Source
1392502-82-7
SECONDARY_CAS_RN
1449746-00-2
SECONDARY_CAS_RN
71488522
PUBCHEM_CID
9NN2OZ1YX4
UNII
C000626298
MESH_SUPPLEMENTAL_RECORD_UI
C4705074
UMLSCUI
CHEBI:167899
CHEBI
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Pharmaceutical products:
None
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mefuparib