prabotulinumtoxinA 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5331 93384-43-1

Description:

MoleculeDescription

Synonyms:

  • prabotulinumtoxinA
  • prabotulinumtoxinA-xvsf
  • jeuveau
  • DWP450
PrabotulinumtoxinA-xvfs is an acetylcholine release inhibitor and a neuromuscular blocking agent
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Feb. 1, 2019 FDA EVOLUS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1148.95 167 479 1122 1101773 89525073
Drug ineffective 709.52 167 373 1228 1383925 89242921
Drug effect less than expected 676.43 167 113 1488 6025 90620821

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 874.57 131.49 372 810 1499813 109088304
Drug effect less than expected 670.70 131.49 107 1075 7213 110580904
Drug ineffective 357.96 131.49 209 973 1520331 109067786

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:176497 geroprotector

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rhytidectomy of glabellar frown lines indication 14667004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Synaptosomal-associated protein 25 Cytosolic other BLOCKER DRUG LABEL DRUG LABEL

External reference:

IDSource
0A6JH35GMQ UNII
4038426 VANDF
C4762545 UMLSCUI
CHEBI:756735 CHEBI
CHEMBL4297229 ChEMBL_ID
DB00083 DRUGBANK_ID
D11405 KEGG_DRUG
C000630868 MESH_SUPPLEMENTAL_RECORD_UI
C586826 MESH_SUPPLEMENTAL_RECORD_UI
1674071000168107 SNOMEDCT_US
328337 MMSL
37848 MMSL
d09465 MMSL
2117872 RXNORM

Pharmaceutical products:

None