evocalcet Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
5307 870964-67-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • evocalcet
  • orkedia
  • KHK-7580
  • KHK7580
  • MT-4580
Evocalcet is a new type of oral calcimimetics agent. The drug suppresses parathyroid hormone secretion by acting on the calcium receptors on parathyroid gland cells.
  • Molecular weight: 374.48
  • Formula: C24H26N2O2
  • CLOGP: 1.86
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 52.57
  • ALOGS: -5.22
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 23, 2017 PMDA Kyowa Hakko Kirin Co., Ltd.

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Secondary hyperparathyroidism indication 91478007 DOID:12466

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.32 acidic
pKa2 8.08 Basic
pKa3 4.84 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Extracellular calcium-sensing receptor GPCR AGONIST EC50 7.03 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
C4519114 UMLSCUI
H43 PDB_CHEM_ID
CHEMBL4297621 ChEMBL_ID
DB12388 DRUGBANK_ID
D11063 KEGG_DRUG
C000631688 MESH_SUPPLEMENTAL_RECORD_UI
71242808 PUBCHEM_CID
9042 IUPHAR_LIGAND_ID
10098 INN_ID
E58MLH082P UNII

Pharmaceutical products:

None