imrecoxib Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
selective cyclo-oxygenase inhibitors 5250 395683-14-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • imrecoxib
  • BAP-909
Imrecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor indicated for treatment of osteoarthritis.
  • Molecular weight: 369.48
  • Formula: C21H23NO3S
  • CLOGP: 2.71
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 54.45
  • ALOGS: -4.84
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 20, 2011 China Food and Drug Administration (CFDA) HengRui

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Osteoarthritis indication 396275006

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7.82 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Prostaglandin G/H synthase 2 Enzyme IC50 7.75 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 6.94 CHEMBL

External reference:

IDSource
SGW6W5758V UNII
C1505698 UMLSCUI
CHEMBL504535 ChEMBL_ID
11682175 PUBCHEM_CID
DB12354 DRUGBANK_ID
C488833 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None