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zabofloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibacterials, nalidixic acid derivatives | 5249 | 219680-11-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Zabofloxacin is a fluoroquinolone antibiotic with enhanced in-vitro activity against Streptococcus pneumoniae, including strains resistant to other antibiotics. The spectrum of activity of Zabofloxacin includes those bacterial strains that are responsible for most community-acquired respiratory infections.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -0.469 | Moderate | 0.66 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 7.907 | Moderate | 0.66 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 1.758 | 10^-6 cm/s | Moderate | 0.66 |
| dh-clint | Dog hepatocyte intrinsic clearance | 0.811 | uL/min/10^6 cells | Moderate | 0.66 |
| dppb | Dog plasma protein binding (% unbound) | 74.340 | % | Moderate | 0.66 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 78.370 | % | Moderate | 0.66 |
| herg | hERG pIC50 | 4.474 | pIC50 | Moderate | 0.66 |
| hh-clint | Human hepatocyte intrinsic clearance | 0.964 | uL/min/10^6 cells | Moderate | 0.66 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.034 | uL/min/mg protein | Moderate | 0.66 |
| hppb | Human plasma protein binding (% unbound) | 74.950 | % | Moderate | 0.66 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 7.568 | Moderate | 0.66 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 1.694 | Moderate | 0.66 | |
| mppb | Mouse plasma protein binding (% unbound) | 61.420 | Moderate | 0.66 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 8.650 | Moderate | 0.66 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | Moderate | 0.66 | |
| pppb | Pig plasma protein binding (% unbound) | 82.120 | % | Moderate | 0.66 |
| rh-clint | Rat hepatocyte intrinsic clearance | 0.845 | uL/min/10^6 cells | Moderate | 0.66 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 88.070 | % | Moderate | 0.66 |
| rppb | Rat plasma protein binding (% unbound) | 51.500 | % | Moderate | 0.66 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 699.842 | uM | Moderate | 0.66 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 20, 2015 | Korean Food and Drug Administration (KFDA) | Dong Wha Pharmaceuticals |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Acute infective exacerbation of chronic obstructive airways disease | indication | 285381006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.27 | acidic |
| pKa2 | 8.46 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| LV66BA6V2G | UNII |
| 623574-00-5 | SECONDARY_CAS_RN |
| C2826065 | UMLSCUI |
| CHEBI:752878 | CHEBI |
| CHEMBL2107811 | ChEMBL_ID |
| 54556623 | PUBCHEM_CID |
| DB12479 | DRUGBANK_ID |
| 8594 | INN_ID |
| C480202 | MESH_SUPPLEMENTAL_RECORD_UI |
| 10873 | IUPHAR_LIGAND_ID |
Pharmaceutical products:
None