simoctocog alfa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
blood factor VIII 5228 1219013-68-9

Description:

MoleculeDescription

Synonyms:

  • simoctocog alfa
  • vihuma
  • nuwiq
  • simoctocog alfa (rFVIII)
Simoctocog alfa (human coagulation factor VIII (rDNA)) is a purified protein that has 1440 amino acids. The amino acid sequence is comparable to the 90 + 80 kDa form of human plasma factor VIII (i.e. B-domain deleted). Simoctocog alfa is produced by recombinant DNA technology in genetical human embryonic kidney (HEK) 293F cells.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Jan. 22, 2021 PMDA FUJIMOTO PHARMACEUTICAL CORPORATION
July 22, 2014 EMA Octapharma AB

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hereditary factor VIII deficiency disease indication 28293008 DOID:12134
Factor VIII deficiency indication 234440005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
U50VWW6XH6 UNII
C4064080 UMLSCUI
CHEBI:753306 CHEBI
CHEMBL2108319 ChEMBL_ID
DB09108 DRUGBANK_ID
D10842 KEGG_DRUG
9371 INN_ID
718853005 SNOMEDCT_US
C0015506 UMLSCUI
231398 MMSL
1729084 RXNORM

Pharmaceutical products:

None