meglumine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5194 6284-40-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • meglumine
1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.
  • Molecular weight: 195.22
  • Formula: C7H17NO5
  • CLOGP: -1.56
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 6
  • TPSA: 113.18
  • ALOGS: 0.09
  • ROTB: 6
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK1,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 33
kinase-selectivity-class ACVRL1,AXL,BMX,CDK1,CDK16,CDK2,CDK4,CDK6,CDK7,CDK9,CHUK,DYRK1A,EPHB4,IGF1R,INSR,IRAK1,IRAK3,IRAK4,KIT,MAP2K6,MAP3K14,MAP3K7,PAK4,PDGFRB,PIK3CB,PIK3CD,TEK,TGFBR1,ZAP70 29
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Nail disorder 416.87 79.18 250 28566 58817 90540814
Blepharospasm 343.55 79.18 216 28600 55229 90544402
Taste disorder 315.73 79.18 213 28603 61333 90538298
Peripheral venous disease 290.67 79.18 229 28587 83692 90515939
Breast cancer stage III 274.46 79.18 222 28594 84225 90515406
Lip dry 257.69 79.18 231 28585 100724 90498907
Facet joint syndrome 256.82 79.18 228 28588 98161 90501470
Epilepsy 250.14 79.18 208 28608 81998 90517633
Hypercholesterolaemia 244.05 79.18 224 28592 100668 90498963
Onychomadesis 237.78 79.18 160 28656 45838 90553793
Obesity 235.49 79.18 224 28592 105283 90494348
Product label confusion 229.65 79.18 122 28694 22728 90576903
Wound infection 228.21 79.18 221 28595 106181 90493450
Product quality issue 227.51 79.18 194 28622 79131 90520500
Bursitis 209.49 79.18 233 28583 131421 90468210
Night sweats 203.35 79.18 227 28589 128539 90471092
Joint range of motion decreased 202.10 79.18 232 28584 135411 90464220
Inflammation 199.22 79.18 264 28552 178328 90421303
Adverse reaction 197.22 79.18 121 28695 29591 90570040
Lung disorder 193.05 79.18 238 28578 149645 90449986
Onychomycosis 183.61 79.18 126 28690 37250 90562381
Coeliac disease 176.88 79.18 132 28684 44478 90555153
Finger deformity 176.17 79.18 117 28699 32780 90566851
Back injury 173.88 79.18 133 28683 46489 90553142
Liver injury 170.31 79.18 239 28577 170328 90429303
Gastrooesophageal reflux disease 164.47 79.18 232 28584 166105 90433526
Folliculitis 163.39 79.18 258 28558 204095 90395536
Live birth 163.36 79.18 161 28655 78946 90520685
Irritable bowel syndrome 163.24 79.18 260 28556 207188 90392443
Osteoarthritis 157.70 79.18 248 28568 195482 90404149
Type 2 diabetes mellitus 152.09 79.18 249 28567 202995 90396636
Muscle injury 150.93 79.18 230 28586 176424 90423207
Memory impairment 144.01 79.18 239 28577 197005 90402626
Helicobacter infection 143.55 79.18 258 28558 226592 90373039
Grip strength decreased 140.61 79.18 160 28656 92416 90507215
Dry mouth 137.01 79.18 225 28591 183834 90415797
Blood cholesterol increased 130.85 79.18 236 28580 207776 90391855
C-reactive protein increased 129.99 79.18 218 28598 181171 90418460
Fibromyalgia 129.72 79.18 234 28582 206035 90393596
Musculoskeletal pain 128.33 79.18 210 28606 171041 90428590
Liver function test increased 124.38 79.18 144 28672 84711 90514920
Psoriatic arthropathy 122.46 79.18 242 28574 228093 90371538
Duodenal ulcer perforation 118.02 79.18 234 28582 221054 90378577
Lower respiratory tract infection 116.01 79.18 250 28566 250409 90349222
Drug-induced liver injury 113.90 79.18 142 28674 90176 90509455
Hepatitis 110.35 79.18 124 28692 70615 90529016
Impaired healing 106.54 79.18 232 28584 233967 90365664
Pericarditis 102.37 79.18 249 28567 269902 90329729
Paraesthesia 101.62 79.18 237 28579 250089 90349542
Neck pain 99.55 79.18 150 28666 113813 90485818
Anti-cyclic citrullinated peptide antibody positive 99.44 79.18 227 28589 236206 90363425
Muscle spasms 96.32 79.18 233 28583 251650 90347981
Wheezing 90.77 79.18 220 28596 237860 90361771
Pyrexia 88.70 79.18 50 28766 660435 89939196
Pemphigus 86.49 79.18 264 28552 326600 90273031
Hypoaesthesia 86.16 79.18 257 28559 313953 90285678
Hand deformity 85.66 79.18 247 28569 296115 90303516
Back pain 84.10 79.18 4 28812 317171 90282460
Glossodynia 83.37 79.18 258 28558 321521 90278110
Injection site reaction 81.55 79.18 122 28694 91958 90507673
Blister 81.02 79.18 220 28596 254778 90344853
Drug ineffective 80.25 79.18 204 28612 1384094 89215537
Wound 79.47 79.18 244 28572 302736 90296895

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Nail disorder 466.01 127.57 249 28444 57686 110502920
Blepharospasm 386.43 127.57 216 28477 54635 110505971
Taste disorder 346.10 127.57 214 28479 65173 110495433
Peripheral venous disease 331.88 127.57 229 28464 83888 110476718
Breast cancer stage III 327.80 127.57 222 28471 78895 110481711
Hypercholesterolaemia 304.66 127.57 224 28469 90613 110469993
Facet joint syndrome 302.93 127.57 229 28464 96599 110464007
Lip dry 300.57 127.57 231 28462 99852 110460754
Wound infection 288.26 127.57 222 28471 96243 110464363
Product quality issue 266.84 127.57 194 28499 77105 110483501
Onychomadesis 263.52 127.57 158 28535 45505 110515101
Joint range of motion decreased 262.75 127.57 232 28461 121600 110439006
Obesity 260.87 127.57 224 28469 113127 110447479
Bursitis 253.81 127.57 234 28459 129684 110430922
Epilepsy 253.19 127.57 209 28484 100000 110460606
Irritable bowel syndrome 251.88 127.57 259 28434 163956 110396650
Product label confusion 250.97 127.57 121 28572 22556 110538050
Folliculitis 243.82 127.57 257 28436 167396 110393210
Night sweats 234.35 127.57 227 28466 133756 110426850
Liver injury 232.04 127.57 238 28455 150175 110410431
Muscle injury 228.51 127.57 229 28464 140578 110420028
Helicobacter infection 226.55 127.57 257 28436 181620 110378986
Inflammation 225.49 127.57 264 28429 192974 110367632
Adverse reaction 220.55 127.57 121 28572 29473 110531133
Type 2 diabetes mellitus 214.92 127.57 247 28446 176985 110383621
Osteoarthritis 210.57 127.57 248 28445 182375 110378231
Live birth 205.52 127.57 159 28534 69325 110491281
Coeliac disease 202.56 127.57 131 28562 43056 110517550
Onychomycosis 200.98 127.57 125 28568 38406 110522200
Pemphigus 200.22 127.57 262 28431 214308 110346298
Fibromyalgia 200.20 127.57 234 28459 170675 110389931
Finger deformity 197.40 127.57 117 28576 32975 110527631
Lung disorder 196.87 127.57 238 28455 179809 110380797
Back injury 196.21 127.57 133 28560 47266 110513340
Duodenal ulcer perforation 192.83 127.57 234 28459 177466 110383140
Gastrooesophageal reflux disease 188.82 127.57 233 28460 179743 110380863
Blood cholesterol increased 187.10 127.57 235 28458 184550 110376056
Glossodynia 185.65 127.57 257 28436 221747 110338859
Grip strength decreased 185.52 127.57 159 28534 80015 110480591
Psoriatic arthropathy 183.15 127.57 240 28453 196521 110364085
Memory impairment 181.43 127.57 239 28454 196705 110363901
Anti-cyclic citrullinated peptide antibody positive 175.64 127.57 226 28467 181758 110378848
Pericarditis 173.32 127.57 247 28446 218867 110341739
Hand deformity 172.37 127.57 246 28447 218260 110342346
Impaired healing 169.38 127.57 231 28462 196486 110364120
Dry mouth 159 127.57 226 28467 199722 110360884
Lower respiratory tract infection 156.59 127.57 249 28444 242857 110317749
Wound 154.97 127.57 243 28450 234194 110326412
Musculoskeletal pain 148.66 127.57 209 28484 182814 110377792
Systemic lupus erythematosus 144.25 127.57 246 28447 254092 110306514
Liver function test increased 141.70 127.57 143 28550 88405 110472201
Maternal exposure during pregnancy 134.73 127.57 239 28454 254644 110305962
C-reactive protein increased 134.55 127.57 219 28474 217700 110342906
Blister 127.69 127.57 219 28474 227157 110333449

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003287 Contrast Media

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.75 acidic
pKa2 13.95 acidic
pKa3 8.86 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
6HG8UB2MUY UNII
4019579 VANDF
C0025179 UMLSCUI
CHEBI:59732 CHEBI
CHEMBL1200570 ChEMBL_ID
8567 PUBCHEM_CID
DB09415 DRUGBANK_ID
D01796 KEGG_DRUG
D008536 MESH_DESCRIPTOR_UI
4205 INN_ID
NOCODE MMSL
010198 NDDF
6704 RXNORM

Pharmaceutical products:

None