carprofen Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 518 53716-49-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Ro 205720
  • Ro-205720
  • rimadyl
  • carprofen
  • carprodyl
anti-inflammatory drug (NSAID) of the propionic acid class with selective inhibition of COX-2 versus COX-1
  • Molecular weight: 273.72
  • Formula: C15H12ClNO2
  • CLOGP: 3.98
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 53.09
  • ALOGS: -4.86
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.51 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 31, 1987 FDA ROCHE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:47868 photosensitizing agent
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D017319 Photosensitizing Agents
MeSH PA D011838 Radiation-Sensitizing Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.53 acidic
pKa2 11.59 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 7 CHEMBL CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.88 CHEMBL
Fatty-acid amide hydrolase 1 Enzyme IC50 4.10 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.89 CHEMBL

External reference:

IDSource
C1702507 UMLSCUI
D03410 KEGG_DRUG
424611009 SNOMEDCT_US
20343 RXNORM
4025237 VANDF
125710006 SNOMEDCT_US
005102 NDDF
CHEBI:364453 CHEBI
CHEMBL1316 ChEMBL_ID
DB00821 DRUGBANK_ID
FFL0D546HO UNII
3980 INN_ID
7141 IUPHAR_LIGAND_ID
2581 PUBCHEM_CID
C007005 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None