DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
eldecalcitol 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
Vitamin D analogues/derivatives
5169
104121-92-8
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
eldecalcitol
ED-71
an analog of vitamin D for the treatment of osteoporosis
Molecular weight: 490.73
Formula: C30H50O5
CLOGP: 6.09
LIPINSKI: 1
HAC: 5
HDO: 4
TPSA: 90.15
ALOGS: -4.67
ROTB: 10
Drug dosage:
None
ADMET properties:
None
Approvals:
Show
10
25
50
100
entries
Search:
Date
Agency
Company
Orphan
Jan. 21, 2011
PMDA
Chugai Pharmaceutical Co., Ltd
Showing 1 to 1 of 1 entries
Previous
1
Next
FDA Adverse Event Reporting System (Female)
Show
10
25
50
100
entries
Search:
MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Osteonecrosis of jaw
242.78
24.28
95
5003
35028
63448896
Renal impairment
207.99
24.28
113
4985
88242
63395682
Hypercalcaemia
182.99
24.28
73
5025
28249
63455675
Interstitial lung disease
131.27
24.28
74
5024
61834
63422090
Femoral neck fracture
99.58
24.28
34
5064
8489
63475435
Spinal compression fracture
89.34
24.28
36
5062
14247
63469677
Cerebral infarction
80.52
24.28
39
5059
23854
63460070
Osteomyelitis
74.44
24.28
38
5060
25982
63457942
Fall
74.13
24.28
121
4977
392213
63091711
Hepatic function abnormal
64.37
24.28
39
5059
37103
63446821
Showing 1 to 10 of 39 entries
Previous
1
2
3
4
Next
FDA Adverse Event Reporting System (Male)
Show
10
25
50
100
entries
Search:
MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Interstitial lung disease
53.39
28.88
29
949
65253
34890700
Hypercalcaemia
35.20
28.88
14
964
15454
34940499
Renal impairment
29.61
28.88
23
955
94490
34861463
Hypocalcaemia
29.13
28.88
14
964
24275
34931678
Showing 1 to 4 of 4 entries
Previous
1
Next
FDA Adverse Event Reporting System (Geriatric)
Show
10
25
50
100
entries
Search:
MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Osteonecrosis of jaw
241.72
20.75
100
6209
43126
79694953
Hypercalcaemia
195.02
20.75
83
6226
38347
79699732
Renal impairment
178.81
20.75
126
6183
157657
79580422
Interstitial lung disease
156.27
20.75
102
6207
112498
79625581
Femoral neck fracture
106.23
20.75
37
6272
9947
79728132
Spinal compression fracture
83.86
20.75
36
6273
16922
79721157
Cerebral infarction
79.92
20.75
48
6261
45628
79692451
Osteomyelitis
69.32
20.75
39
6270
32826
79705253
Hypocalcaemia
66.14
20.75
44
6265
49880
79688199
Fall
64.73
20.75
128
6181
487501
79250578
Showing 1 to 10 of 42 entries
Previous
1
2
3
4
5
Next
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
Show
10
25
50
100
entries
Search:
Source
Code
Description
CHEBI has role
CHEBI:25212
metabolites
MeSH PA
D050071
Bone Density Conservation Agents
Showing 1 to 2 of 2 entries
Previous
1
Next
Drug Use
| Suggest Off label Use Form|
|View source of the data|
Show
10
25
50
100
entries
Search:
Disease
Relation
SNOMED_ID
DOID
Osteoporosis
indication
64859006
DOID:11476
Showing 1 to 1 of 1 entries
Previous
1
Next
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
Show
10
25
50
100
entries
Search:
Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
13.2
acidic
pKa2
13.89
acidic
Showing 1 to 2 of 2 entries
Previous
1
Next
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
Show
10
25
50
100
entries
Search:
Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Vitamin D3 receptor
Nuclear hormone receptor
P11473
VDR_HUMAN
AGONIST
UNKNOWN
KEGG DRUG
Vitamin D3 receptor
Transcription factor
VDR_RAT
AGONIST
Kd
8
IUPHAR
Showing 1 to 2 of 2 entries
Previous
1
Next
External reference:
Show
10
25
50
100
entries
Search:
ID
Source
2783
IUPHAR_LIGAND_ID
6918141
PUBCHEM_CID
8867
INN_ID
C2828245
UMLSCUI
C547512
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:73927
CHEBI
CHEMBL4297608
ChEMBL_ID
D07578
KEGG_DRUG
DB05295
DRUGBANK_ID
ED9
PDB_CHEM_ID
Showing 1 to 10 of 11 entries
Previous
1
2
Next
Pharmaceutical products:
None
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
eldecalcitol