chloramphenicol palmitate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5150 530-43-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • chloramphenicol palmitate
  • chloromycetin palmitate
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
  • Molecular weight: 561.54
  • Formula: C27H42Cl2N2O6
  • CLOGP: 8.74
  • LIPINSKI: 2
  • HAC: 8
  • HDO: 2
  • TPSA: 118.77
  • ALOGS: -6.77
  • ROTB: 22
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 65
kinase-selectivity-class AXL,CDK4,EIF2AK3,EPHB4,GRK2,MAP2K6,MAPK7,PDK4,PLK1,STK33,TEK,TTK 12
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA EXT N0000175479 Amphenicols
FDA EPC N0000175480 Amphenicol-class Antibacterial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:48001 protein synthesis inhibitor
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:131604 <em>Mycoplasma genitalium</em> metabolite
CHEBI has role CHEBI:176497 geroprotector

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Bacterial conjunctivitis Indication
Dogs Respiratory tract infections Indication
Dogs Urinary tract infections Indication
Dogs Bacterand enteritis Indication
Dogs Tonsillitis Indication

🐶 Veterinary products

ProductApplicantIngredients
Chloromycetin Palmitate Oral Suspension Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
43VU4207NW UNII
4018199 VANDF
4018201 VANDF
C0055337 UMLSCUI
CHEBI:3605 CHEBI
CLM PDB_CHEM_ID
CHEMBL1506 ChEMBL_ID
D01072 KEGG_DRUG
443382 PUBCHEM_CID
DB14658 DRUGBANK_ID
C030578 MESH_SUPPLEMENTAL_RECORD_UI
20767 RXNORM
20707 MMSL
3887 MMSL
4406 MMSL
73105 MMSL
d00025 MMSL
002767 NDDF
002768 NDDF
29327006 SNOMEDCT_US
372777009 SNOMEDCT_US
57191001 SNOMEDCT_US
C0008168 UMLSCUI
DB00446 DRUGBANK_ID
5959 PUBCHEM_CID
977 INN_ID
D002701 MESH_DESCRIPTOR_UI
CHEBI:17698 CHEBI

Pharmaceutical products:

None