gluconolactone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5144 90-80-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • gluconolactone
  • D-Gluconolactone
  • delta-gluconolactone
  • glucono delta-lactone
  • glucono-delta-lactone
  • Molecular weight: 178.14
  • Formula: C6H10O6
  • CLOGP: -2.23
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 107.22
  • ALOGS: 0.52
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PRKDC,SIK2,STK33,TEK 30
kinase-selectivity-class ACVRL1,AXL,BMX,CDK1,CDK2,CDK4,CDK7,CDK9,CHUK,DYRK1A,GRK2,INSR,IRAK4,MAP2K6,MAP3K14,PIK3CD,PRKDC,TEK,TGFBR1,ZAP70 20
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Oct. 2, 1990 FDA UNITED GUARDIAN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175534 Irrigation
FDA EPC N0000175835 Calculi Dissolution Agent
CHEBI has role CHEBI:75767 animal metabolites
CHEBI has role CHEBI:75771 Mus musculus metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Urinary bladder stone indication 70650003 DOID:11355




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.96 acidic
pKa2 12.58 acidic
pKa3 13.31 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucosylceramidase Enzyme Ki 4.52 CHEMBL

External reference:

IDSource
WQ29KQ9POT UNII
4019568 VANDF
C0061387 UMLSCUI
CHEBI:16217 CHEBI
LGC PDB_CHEM_ID
CHEMBL1200829 ChEMBL_ID
D04332 KEGG_DRUG
7027 PUBCHEM_CID
DB04564 DRUGBANK_ID
25842 RXNORM
NOCODE MMSL
d03715 MMSL
005159 NDDF
427638006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Renacidin HUMAN PRESCRIPTION DRUG LABEL 3 0327-0012 SOLUTION 0.20 g IRRIGATION NDA 14 sections
Krx Aesthetics Biophase Molecular Night Peel HUMAN OTC DRUG LABEL 2 84755-0005 CREAM 100 mg TOPICAL unapproved drug other 8 sections