hemin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5117 16009-13-5

Description:

MoleculeDescription

Synonyms:

  • hemin
  • normosang
  • panhematin
Chloro(7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N(21),N(22),N(23),N(24)) ferrate(2-) dihydrogen.
  • Molecular weight: 651.95
  • Formula: C34H32ClFeN4O4
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 92.22
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Phlebitis 97.82 65.06 16 151 7414 90620866
Device occlusion 67.10 65.06 12 155 9270 90619010

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 93.46 87.31 25 4 638310 41982996

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 64.83 63.98 32 104 1500153 109089010
Phlebitis 64.40 63.98 11 125 9830 110579333

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B06AB01 BLOOD AND BLOOD FORMING ORGANS
OTHER HEMATOLOGICAL AGENTS
OTHER HEMATOLOGICAL AGENTS
Heme products
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:138880 autophagy inducer
CHEBI has role CHEBI:173085 ferroptosis inducer

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute intermittent porphyria indication 234422006 DOID:3890




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
743LRP9S7N UNII
D10003 KEGG_DRUG
4018707 VANDF
C0018988 UMLSCUI
CHEBI:50385 CHEBI
CHEMBL1200662 ChEMBL_ID
CHEMBL3707238 ChEMBL_ID
26945 PUBCHEM_CID
DB03404 DRUGBANK_ID
D006427 MESH_DESCRIPTOR_UI
C048849 MESH_SUPPLEMENTAL_RECORD_UI
5175 RXNORM
11897 MMSL
7548 MMSL
d04360 MMSL
002038 NDDF
27345002 SNOMEDCT_US
424480005 SNOMEDCT_US
743LRP9S7N INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Panhematin HUMAN PRESCRIPTION DRUG LABEL 1 55292-702 POWDER, FOR SOLUTION 7 mg INTRAVENOUS BLA 25 sections