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arterolane 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antimalarial agents, artemisinin related compounds | 5090 | 664338-39-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a trioxolane with antimalarial activity
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,NTRK2,PDK1,PDK4,PRKDC,TEK | 16 | |||
| kinase-selectivity-class | EIF2AK3,GRK2 | 2 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 9, 2012 | CDSCO (INDIA) |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | P01BX02 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS ANTIMALARIALS Other antimalarials |
| CHEBI has role | CHEBI:38068 | antimalarial |
| CHEBI has role | CHEBI:64915 | antiplasmodial drug |
Related Drugs by ATC class:
P01BX Other antimalarials 2 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Falciparum malaria | indication | 62676009 | DOID:14067 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.38 | acidic |
| pKa2 | 9.54 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 3N1TN351VB | UNII |
| 959520-73-1 | SECONDARY_CAS_RN |
| C2977963 | UMLSCUI |
| CHEBI:136054 | CHEBI |
| CHEMBL570680 | ChEMBL_ID |
| 10475633 | PUBCHEM_CID |
| CHEMBL404431 | ChEMBL_ID |
| 8663 | INN_ID |
| C489136 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
None