menadiol sodium diphosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5032 6700-42-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • menadiol sodium diphosphate
  • menadiol sodium diphosphate hexahydrate
  • kappadione
  • menadiol sodium phosphate
  • Molecular weight: 334.16
  • Formula: C11H12O8P2
  • CLOGP: -1.21
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 4
  • TPSA: 133.52
  • ALOGS: -2.59
  • ROTB: 4
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,FLT1,FLT3,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK1,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 73
kinase-selectivity-class ACVR1B,ACVR2B,ALK,AURKA,AURKB,AXL,BMX,BRAF,CAMK2B,CAMK2D,CDK1,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,ERBB4,GRK2,IKBKB,IRAK1,IRAK3,JAK1,JAK2,KDR,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP4K3,MAPK7,MAPK8,PAK4,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,SRC,STK10,STK33,SYK,TEK,TGFBR1,ZAP70 45
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hemorrhage indication 50960005
Obstructive hyperbilirubinemia indication 59848001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.73 acidic
pKa2 2.33 acidic
pKa3 6.78 acidic
pKa4 7.38 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
2OVL75B30W UNII
D04908 KEGG_DRUG
4017786 VUID
N0000146147 NUI
4017786 VANDF
4022117 VANDF
C0127514 UMLSCUI
CHEMBL3989728 ChEMBL_ID
197855 PUBCHEM_CID
DB09332 DRUGBANK_ID
29491 RXNORM
001040 NDDF
126239001 SNOMEDCT_US
350547008 SNOMEDCT_US
421289007 SNOMEDCT_US
C0065932 UMLSCUI
CHEBI:134713 CHEBI
10209 PUBCHEM_CID
C023885 MESH_SUPPLEMENTAL_RECORD_UI
VQ093653DO UNII
CHEBI:6746 CHEBI

Pharmaceutical products:

None