oprelvekin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
interleukin-11 analogues and derivatives 5026 145941-26-0

Description:

MoleculeDescription

Synonyms:

  • oprelvekin
  • oprelvekin (genetical recombination)
  • neumega
  • IL-11
  • IL11
Oprelvekin is a recombinant human Interleukin-11. Interleukin eleven (IL-11) is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3.50 mg P

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Nov. 25, 1997 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Oedema peripheral 16.11 0 4 17 23759 2334305

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC L03AC02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSTIMULANTS
IMMUNOSTIMULANTS
Interleukins
FDA EPC N0000175668 Megakaryocyte Growth Factor
FDA Chemical/Ingredient N0000170935 Thrombopoietin
MeSH PA D000970 Antineoplastic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Thrombocytopenic disorder indication 302215000 DOID:1588

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Interleukin-11 receptor Membrane receptor AGONIST DRUG LABEL DRUG LABEL

External reference:

IDSource
D05266 KEGG_DRUG
4021084 VUID
N0000148542 NUI
C0537670 UMLSCUI
410938009 SNOMEDCT_US
4021084 VANDF
139994 RXNORM
007281 NDDF
d04254 MMSL
5205 MMSL
108968006 SNOMEDCT_US
DB00038 DRUGBANK_ID
HM5641GA6F UNII
7558 INN_ID
CHEMBL1201573 ChEMBL_ID
4976 IUPHAR_LIGAND_ID
C105308 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None