pancreozymin

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Stem definition	Drug id	CAS RN
	4945	9011-97-6

Stem definition

Drug id

CAS RN

4945

9011-97-6

Description:

Molecule	Description
Synonyms: pancreozymin cholecystokinin CCK pankreozymin CCK-PZ uropancreozymin cholecystokinin 33 CCK-33	A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety. Molecular weight: Formula: CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

pancreozymin
cholecystokinin
CCK
pankreozymin
CCK-PZ
uropancreozymin
cholecystokinin 33
CCK-33

A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.

Molecular weight:
Formula:
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Source	Code	Description
ATC	V04CK02	VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for pancreatic function
MeSH PA	D002756	Cholagogues and Choleretics
MeSH PA	D005765	Gastrointestinal Agents

Source

Code

Description

ATC

V04CK02

VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for pancreatic function

MeSH PA

D002756

Cholagogues and Choleretics

MeSH PA

D005765

Gastrointestinal Agents

Disease	Relation	SNOMED_ID	DOID
Pancreatic function test	indication	252243002

Disease

Relation

SNOMED_ID

DOID

Pancreatic function test

indication

252243002

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source
Cholecystokinin receptor type A	GPCR	P32238	CCKAR_HUMAN		EC50	10	CHEMBL
Gastrin/cholecystokinin type B receptor	GPCR	P32239	GASR_HUMAN	AGONIST	IC50	8.80	IUPHAR
Gastrin/cholecystokinin type B receptor	GPCR		GASR_MOUSE		IC50	9.52	CHEMBL
Cholecystokinin receptor type A	GPCR		CCKAR_CAVPO		Ki	9.55	CHEMBL
Cholecystokinin receptor type A	GPCR		CCKAR_RAT	AGONIST	Kd	9.30	IUPHAR
Gastrin/cholecystokinin type B receptor	GPCR		GASR_RAT		Ki	9.39	CHEMBL

Target

Class

Pharos

UniProt

Action

Type

Activity value
(-log[M])

Mechanism
action

Bioact source

MoA source

Cholecystokinin receptor type A

GPCR

P32238

CCKAR_HUMAN

EC50

CHEMBL

Gastrin/cholecystokinin type B receptor

GPCR

P32239

GASR_HUMAN

AGONIST

IC50

8.80

IUPHAR

Gastrin/cholecystokinin type B receptor

GPCR

GASR_MOUSE

IC50

9.52

CHEMBL

Cholecystokinin receptor type A

GPCR

CCKAR_CAVPO

9.55

CHEMBL

Cholecystokinin receptor type A

GPCR

CCKAR_RAT

AGONIST

9.30

IUPHAR

Gastrin/cholecystokinin type B receptor

GPCR

GASR_RAT

9.39

CHEMBL

ID	Source
N0000007750	NUI
C0008328	UMLSCUI
CHEBI:753508	CHEBI
CHEMBL2108550	ChEMBL_ID
DB08862	DRUGBANK_ID
2420	RXNORM
001219	NDDF
25085002	SNOMEDCT_US
46225008	SNOMEDCT_US
D002766	MESH_DESCRIPTOR_UI
16129670	PUBCHEM_CID
3551	IUPHAR_LIGAND_ID

Source

N0000007750

NUI

C0008328

UMLSCUI

CHEBI

ChEMBL_ID

DRUGBANK_ID