magaldrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antacids, aluminium salts 4926 74978-16-8

Description:

MoleculeDescription

Synonyms:

  • magnesium aluminate hydrate
  • moalium hydrate
  • magaldrate
  • magaldrate hydrate
  • anhydrous magaldrate
  • magaldrate anhydrous
  • aluminum magnesium hydroxide sulfate
  • riopan
  • AY-5710
  • monalium hydrate
composed of aluminium and magnesium hydroxides and sulphates, used as an antacid
  • Molecular weight:
  • Formula: Al5H31Mg10O39S2(H2O)n
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 390.78 9.94 935 89417 319452 90218643
Carotid artery thrombosis 322.96 9.94 165 90187 8927 90529168
Neurologic neglect syndrome 315.55 9.94 161 90191 8686 90529409
Personality disorder 308.68 9.94 178 90174 12266 90525829
Adjustment disorder 302.49 9.94 161 90191 9481 90528614
Hemiplegia 277.96 9.94 183 90169 15977 90522118
Pemphigus 274.79 9.94 12 90340 326852 90211243
Coordination abnormal 265.00 9.94 198 90154 21158 90516937
Affect lability 238.82 9.94 174 90178 17889 90520206
Glossodynia 235.06 9.94 24 90328 321755 90216340
Motor dysfunction 231.30 9.94 175 90177 19055 90519040
Wound 225.51 9.94 21 90331 302959 90235136
Sensory loss 218.53 9.94 165 90187 17910 90520185
Anti-cyclic citrullinated peptide antibody positive 215.70 9.94 4 90348 236429 90301666
Hypomagnesaemia 213.45 9.94 218 90134 35370 90502725
Aphasia 201.96 9.94 231 90121 42581 90495514
Chronic kidney disease 200.82 9.94 249 90103 49942 90488153
Hand deformity 199.54 9.94 29 90323 296333 90241762
Systemic lupus erythematosus 195.46 9.94 59 90293 361837 90176258
Hemiparesis 185.56 9.94 192 90160 31627 90506468
Duodenal ulcer perforation 183.07 9.94 9 90343 221279 90316816
Hyponatraemia 181.36 9.94 407 89945 133131 90404964
Angioedema 179.31 9.94 269 90083 64607 90473488
Cholestasis 163.06 9.94 191 90161 36108 90501987
Folliculitis 160.83 9.94 11 90341 204342 90333753
Helicobacter infection 157.88 9.94 20 90332 226830 90311265
Eating disorder 157.61 9.94 166 90186 27907 90510188
Muscle injury 157.14 9.94 4 90348 176650 90361445
Sensitisation 154.78 9.94 78 90274 4097 90533998
Swelling 147.33 9.94 121 90231 418937 90119158
Loss of employment 144.60 9.94 67 90285 2920 90535175
Psoriatic arthropathy 143.30 9.94 27 90325 228308 90309787
Cardiospasm 141.46 9.94 69 90283 3377 90534718
Gangrene 141.34 9.94 111 90241 12765 90525330
Palmoplantar keratoderma 140.31 9.94 69 90283 3438 90534657
Polycystic ovaries 137.89 9.94 80 90272 5574 90532521
Muscle spasticity 137.71 9.94 173 90179 35149 90502946
Arterial occlusive disease 135.99 9.94 107 90245 12339 90525756
Tubulointerstitial nephritis 135.45 9.94 146 90206 25197 90512898
Hypocalcaemia 133.57 9.94 187 90165 42181 90495914
Irritable bowel syndrome 133.49 9.94 23 90329 207425 90330670
Alopecia 131.53 9.94 181 90171 494890 90043205
Pruritus genital 128.74 9.94 71 90281 4487 90533608
Dysarthria 128.43 9.94 210 90142 54272 90483823
Dysphagia 127.25 9.94 319 90033 111959 90426136
Atrial tachycardia 125.87 9.94 77 90275 5913 90532182
Blister 124.78 9.94 49 90303 254949 90283146
Drug ineffective 124.66 9.94 840 89512 1383458 89154637
Injury 124.55 9.94 23 90329 197326 90340769
Synovitis 123.77 9.94 89 90263 329663 90208432
Discomfort 121.22 9.94 61 90291 274274 90263821
Drug interaction 121.01 9.94 571 89781 275882 90262213
Arthropathy 119.95 9.94 113 90239 366129 90171966
Sleep terror 119.16 9.94 67 90285 4397 90533698
Ejection fraction 116.77 9.94 58 90294 2953 90535142
Sinus congestion 109.59 9.94 136 90216 27288 90510807
Tension headache 107.66 9.94 76 90276 7433 90530662
Maternal exposure during pregnancy 106.70 9.94 121 90231 359942 90178153
Carotid artery occlusion 104.65 9.94 70 90282 6272 90531823
Exposure during pregnancy 102.37 9.94 55 90297 238355 90299740
C-reactive protein abnormal 99.83 9.94 7 90345 127422 90410673
Renal injury 99.06 9.94 82 90270 10161 90527934
Drug reaction with eosinophilia and systemic symptoms 98.33 9.94 163 90189 42595 90495500
Hepatic enzyme increased 95.62 9.94 132 90220 360604 90177491
Hepatic cytolysis 95.28 9.94 135 90217 30781 90507314
Death 93.55 9.94 197 90155 456354 90081741
Hepatocellular injury 93.04 9.94 129 90223 28829 90509266
Immunisation 92.91 9.94 45 90307 2168 90535927
Swollen tongue 92.31 9.94 165 90187 45791 90492304
Inappropriate antidiuretic hormone secretion 91.55 9.94 105 90247 19400 90518695
Stomatitis 90.79 9.94 84 90268 274614 90263481
Respiratory tract congestion 89.41 9.94 123 90229 27287 90510808
Lip dry 87.16 9.94 3 90349 100952 90437143
Skin haemorrhage 86.99 9.94 107 90245 21273 90516822
Anosmia 85.31 9.94 74 90278 9774 90528321
Product dose omission issue 84.25 9.94 100 90252 291587 90246508
Pericarditis 84.20 9.94 87 90265 270064 90268031
Lymphatic fistula 84.15 9.94 37 90315 1424 90536671
Blood cholesterol increased 83.58 9.94 52 90300 207960 90330135
Angina pectoris 83.05 9.94 144 90208 39016 90499079
Femoral hernia incarcerated 83.03 9.94 37 90315 1471 90536624
Type 2 diabetes mellitus 82.79 9.94 50 90302 203194 90334901
Nephrectomy 82.32 9.94 40 90312 1941 90536154
Interstitial lung disease 82.30 9.94 213 90139 76192 90461903
Cross sensitivity reaction 82.06 9.94 45 90307 2812 90535283
Sneezing 81.29 9.94 123 90229 29746 90508349
Palpitations 81.19 9.94 310 90042 136418 90401677
Human rhinovirus test positive 79.62 9.94 31 90321 872 90537223
Presbyacusis 79.42 9.94 45 90307 2997 90535098
Impaired work ability 79.08 9.94 97 90255 19229 90518866
Hypoaesthesia 78.32 9.94 120 90232 314090 90224005
Rheumatoid factor positive 77.56 9.94 37 90315 171613 90366482
Pleural thickening 76.67 9.94 45 90307 3203 90534892
Wound infection pseudomonas 75.59 9.94 38 90314 1985 90536110
Respiratory syncytial virus test positive 74.86 9.94 31 90321 1027 90537068
Pancreatic steatosis 73.83 9.94 35 90317 1607 90536488
Joint swelling 73.82 9.94 256 90096 503044 90035051
Disturbance in attention 73.55 9.94 152 90200 46957 90491138
Lactic acidosis 73.19 9.94 158 90194 50305 90487790
Arterial haemorrhage 73.18 9.94 40 90312 2483 90535612
Pleural fibrosis 72.44 9.94 45 90307 3551 90534544
Blood magnesium increased 72.10 9.94 44 90308 3364 90534731
Blood test abnormal 71.34 9.94 96 90256 20856 90517239
Subarachnoid haemorrhage 70.27 9.94 88 90264 17816 90520279
Ill-defined disorder 67.90 9.94 51 90301 184840 90353255
Mobility decreased 67.16 9.94 91 90261 250643 90287452
Knee arthroplasty 66.84 9.94 4 90348 83178 90454917
Joint range of motion decreased 64.79 9.94 27 90325 135616 90402479
Prescribed overdose 64.62 9.94 10 90342 97615 90440480
Osteopenia 64.42 9.94 96 90256 22906 90515189
Autoimmune disorder 63.82 9.94 3 90349 76741 90461354
Muscular weakness 63.81 9.94 388 89964 206278 90331817
Rhinitis allergic 63.50 9.94 81 90271 16704 90521391
Ventricular tachycardia 63.38 9.94 99 90253 24609 90513486
Lower respiratory tract infection 63.15 9.94 95 90257 250564 90287531
Liver injury 62.69 9.94 47 90305 170520 90367575
Peripheral venous disease 61.89 9.94 6 90346 83915 90454180
Epigastric discomfort 61.81 9.94 55 90297 7513 90530582
Cerebrovascular accident 61.33 9.94 265 90087 123268 90414827
Night sweats 60.91 9.94 26 90326 128740 90409355
Seroma 60.90 9.94 38 90314 3022 90535073
Sinus disorder 60.80 9.94 117 90235 34330 90503765
Lower limb fracture 60.33 9.94 7 90345 85006 90453089
Subacute cutaneous lupus erythematosus 60.22 9.94 40 90312 3542 90534553
Ejection fraction abnormal 60.09 9.94 35 90317 2456 90535639
Hyperkalaemia 59.85 9.94 171 90181 64793 90473302
Weight increased 59.63 9.94 215 90137 417712 90120383
Sleep disorder due to general medical condition, insomnia type 59.28 9.94 27 90325 128667 90409428
Road traffic accident 59.02 9.94 17 90335 107609 90430486
Diplopia 58.82 9.94 104 90248 28610 90509485
Agranulocytosis 58.28 9.94 116 90236 34886 90503209
Facial pain 56.93 9.94 68 90284 13114 90524981
Gait inability 56.92 9.94 38 90314 146418 90391677
Diverticulum intestinal 56.62 9.94 57 90295 9085 90529010
Hiatus hernia 56.06 9.94 95 90257 25266 90512829
Physical deconditioning 55.50 9.94 32 90320 2203 90535892
Facet joint syndrome 54.96 9.94 15 90337 98374 90439721
Tinnitus 54.73 9.94 128 90224 42974 90495121
Impaired healing 54.07 9.94 94 90258 234105 90303990
Haemarthrosis 53.98 9.94 39 90313 3955 90534140
Infection 53.84 9.94 183 90169 361911 90176184
Urate nephropathy 53.60 9.94 15 90337 142 90537953
Rash maculo-papular 53.55 9.94 123 90229 40810 90497285
Hypokalaemia 53.09 9.94 265 90087 130851 90407244
Deafness neurosensory 52.49 9.94 48 90304 6793 90531302
Pain of skin 52.20 9.94 72 90280 16010 90522085
Obesity 52.03 9.94 20 90332 105487 90432608
Grip strength decreased 51.93 9.94 14 90338 92562 90445533
Contusion 51.72 9.94 108 90244 251108 90286987
Fall 50.47 9.94 716 89636 481094 90057001
Cough 49.95 9.94 575 89777 368387 90169708
Anaphylactic reaction 49.94 9.94 196 90156 87328 90450767
Aortic valve stenosis 49.68 9.94 38 90314 4202 90533893
Viral test positive 49.45 9.94 20 90332 623 90537472
Carpal tunnel syndrome 49.45 9.94 87 90265 23841 90514254
Hepatic steatosis 49.42 9.94 112 90240 36833 90501262
Cataract 49.15 9.94 171 90181 71921 90466174
End stage renal disease 48.67 9.94 51 90301 8520 90529575
Live birth 48.24 9.94 10 90342 79097 90458998
Pancreatitis acute 48.23 9.94 102 90250 32013 90506082
Hip arthroplasty 47.80 9.94 9 90343 76199 90461896
Prescription form tampering 47.08 9.94 20 90332 707 90537388
Pneumonia haemophilus 46.86 9.94 25 90327 1478 90536617
Vasculitis 46.24 9.94 82 90270 22611 90515484
Infusion related reaction 45.62 9.94 237 90115 416543 90121552
Tachyarrhythmia 45.57 9.94 40 90312 5366 90532729
Multi-organ disorder 45.51 9.94 28 90324 2172 90535923
Condition aggravated 45.31 9.94 378 89974 595167 89942928
Wound infection 44.98 9.94 25 90327 106377 90431718
Sleep apnoea syndrome 44.44 9.94 98 90254 31649 90506446
Nail disorder 44.15 9.94 4 90348 59063 90479032
Cell death 43.98 9.94 31 90321 3024 90535071
Nasopharyngitis 43.16 9.94 234 90118 406870 90131225
Blood pressure systolic abnormal 43.10 9.94 73 90279 19405 90518690
Swelling face 43.07 9.94 178 90174 81174 90456921
Fatigue 42.18 9.94 855 89497 1153168 89384927
Eosinophilia 42.13 9.94 90 90262 28443 90509652
Anaemia vitamin B12 deficiency 41.91 9.94 18 90334 654 90537441
Oedema 41.31 9.94 86 90266 200209 90337886
Rheumatoid nodule 41.26 9.94 73 90279 20093 90518002
Hypercholesterolaemia 40.81 9.94 25 90327 100867 90437228
Eructation 40.35 9.94 52 90300 10830 90527265
Liver function test increased 40.34 9.94 17 90335 84838 90453257
Mesenteric panniculitis 40.29 9.94 13 90339 207 90537888
Transient ischaemic attack 40.11 9.94 114 90238 43062 90495033
Rhabdomyolysis 39.75 9.94 127 90225 51129 90486966
Treatment failure 39.68 9.94 162 90190 303766 90234329
Pregnancy 39.62 9.94 7 90345 62040 90476055
Amniotic fluid index increased 39.32 9.94 11 90341 104 90537991
Therapy non-responder 39.29 9.94 47 90305 136657 90401438
Tenosynovitis stenosans 38.96 9.94 32 90320 3921 90534174
Hepatic cyst 38.94 9.94 40 90312 6528 90531567
Muscle twitching 38.84 9.94 79 90273 24123 90513972
Urticaria 38.79 9.94 170 90182 312564 90225531
Electric shock 38.41 9.94 23 90329 1699 90536396
Blindness 38.31 9.94 83 90269 26485 90511610
Arthritis 37.83 9.94 291 90061 167024 90371071
Wound dehiscence 37.35 9.94 37 90315 5785 90532310
Post cholecystectomy syndrome 37.24 9.94 18 90334 863 90537232
Aortic arteriosclerosis 37.13 9.94 42 90310 7642 90530453
Abdominal pain upper 37.07 9.94 500 89852 332174 90205921
Mouth haemorrhage 36.95 9.94 44 90308 8457 90529638
Lip swelling 36.90 9.94 103 90249 38507 90499588
Osteosclerosis 36.49 9.94 32 90320 4288 90533807
Laryngitis 36.46 9.94 4 90348 50749 90487346
Tongue biting 36.30 9.94 24 90328 2109 90535986
Toxic skin eruption 36.08 9.94 60 90292 15714 90522381
Pulmonary haemorrhage neonatal 36.04 9.94 9 90343 52 90538043
Sciatica 35.89 9.94 29 90323 101353 90436742
Faecaloma 35.82 9.94 48 90304 10383 90527712
Alanine aminotransferase increased 35.13 9.94 220 90132 118118 90419977
Contraindicated product administered 35.04 9.94 182 90170 319957 90218138
Hallucination 34.66 9.94 144 90208 65815 90472280
Hypothyroidism 34.47 9.94 124 90228 53003 90485092
Blood pressure diastolic abnormal 34.44 9.94 67 90285 19814 90518281
Groin pain 34.24 9.94 51 90301 12162 90525933
Dysphonia 34.16 9.94 139 90213 62945 90475150
Bone cyst 33.93 9.94 24 90328 2354 90535741
Aplastic anaemia 33.80 9.94 53 90299 13216 90524879
Ulcer 33.69 9.94 90 90262 32792 90505303
Urinary retention 33.45 9.94 98 90254 37646 90500449
Anuria 33.41 9.94 56 90296 14762 90523333
Cardiac failure 33.40 9.94 205 90147 109291 90428804
Taste disorder 33.23 9.94 10 90342 61536 90476559
Skin exfoliation 33.17 9.94 145 90207 67768 90470327
Anaemia macrocytic 32.99 9.94 31 90321 4541 90533554
Chest discomfort 32.60 9.94 243 90109 138122 90399973
Neurosis 32.54 9.94 13 90339 392 90537703
Escherichia infection 31.82 9.94 57 90295 15838 90522257
Bone erosion 31.72 9.94 7 90345 53014 90485081
Dry eye 31.65 9.94 128 90224 57803 90480292
Acute generalised exanthematous pustulosis 31.18 9.94 52 90300 13651 90524444
Nephropathy 30.96 9.94 42 90310 9193 90528902
Blood immunoglobulin A increased 30.88 9.94 18 90334 1265 90536830
Aspartate aminotransferase 30.83 9.94 15 90337 730 90537365
Product quality issue 30.26 9.94 21 90331 79304 90458791
Dermatitis bullous 30.25 9.94 44 90308 10272 90527823
Cutaneous lupus erythematosus 30.23 9.94 25 90327 3093 90535002
Quadriparesis 30.21 9.94 23 90329 2526 90535569
Myocardial infarction 30.21 9.94 195 90157 105777 90432318
Acute hepatitis B 30.19 9.94 12 90340 357 90537738
Deformity 30.15 9.94 48 90304 12122 90525973
Device expulsion 29.94 9.94 3 90349 40883 90497212
Injection site pain 29.92 9.94 82 90270 173617 90364478
Rash papular 29.82 9.94 64 90288 20291 90517804
Disability 29.81 9.94 3 90349 40742 90497353
Renal failure 29.69 9.94 228 90124 130779 90407316
Intervertebral discitis 29.50 9.94 29 90323 4491 90533604
Pain 29.34 9.94 763 89589 995578 89542517
Drug hypersensitivity 29.31 9.94 308 90044 463301 90074794
Patent ductus arteriosus 29.24 9.94 29 90323 4540 90533555
Influenza like illness 29.21 9.94 158 90194 80453 90457642
Hypertensive nephropathy 29.11 9.94 14 90338 664 90537431
Electrocardiogram QT prolonged 29.00 9.94 146 90206 72310 90465785
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 28.95 9.94 8 90344 72 90538023
Erythema dyschromicum perstans 28.75 9.94 8 90344 74 90538021
Rhinorrhoea 28.63 9.94 168 90184 88148 90449947
Ear infection 28.62 9.94 17 90335 69758 90468337
Product use issue 28.52 9.94 202 90150 329717 90208378
Injection site erythema 28.16 9.94 34 90318 98468 90439627
Congenital tricuspid valve incompetence 28.15 9.94 9 90343 139 90537956
Vulvovaginal inflammation 28.01 9.94 16 90336 1082 90537013
Granulocyte count increased 27.91 9.94 18 90334 1516 90536579
Renal disorder 27.73 9.94 92 90260 37767 90500328
Cyst 27.70 9.94 55 90297 16506 90521589
Renal tubular disorder 27.58 9.94 24 90328 3183 90534912
Gastritis 27.56 9.94 98 90254 41655 90496440
Haematuria 27.49 9.94 87 90265 34850 90503245
Vitamin B12 increased 27.38 9.94 19 90333 1807 90536288
Eye pruritus 27.31 9.94 77 90275 28950 90509145
Anal abscess 27.25 9.94 31 90321 5677 90532418
Cystitis 27.10 9.94 135 90217 66583 90471512
Gallbladder polyp 27.08 9.94 15 90337 956 90537139
Neonatal hypotension 27.03 9.94 9 90343 159 90537936
Foetal macrosomia 26.90 9.94 10 90342 247 90537848
Gastric polyps 26.88 9.94 28 90324 4644 90533451
Catarrh 26.87 9.94 18 90334 1616 90536479
Anxiety 26.85 9.94 446 89906 309326 90228769
Inflammatory marker increased 26.58 9.94 39 90313 9175 90528920
Musculoskeletal pain 26.49 9.94 85 90267 171166 90366929
Occupational asthma 26.37 9.94 9 90343 172 90537923
Seizure 26.32 9.94 72 90280 152557 90385538
Burns second degree 26.00 9.94 19 90333 1961 90536134
Blood parathyroid hormone decreased 26.00 9.94 45 90307 12171 90525924
Left-to-right cardiac shunt 26.00 9.94 10 90342 272 90537823
Hepatitis B DNA increased 25.73 9.94 10 90342 280 90537815
Psychomotor skills impaired 25.73 9.94 22 90330 2850 90535245
Blood creatinine increased 25.57 9.94 181 90171 101205 90436890
Simple partial seizures 25.12 9.94 13 90339 722 90537373
Cognitive disorder 25.12 9.94 136 90216 69271 90468824
Pancreatitis necrotising 25.00 9.94 20 90332 2361 90535734
Walking aid user 25.00 9.94 3 90349 35503 90502592
Tricuspid valve incompetence 24.96 9.94 53 90299 16678 90521417
Sleep disorder 24.93 9.94 107 90245 197923 90340172
Muscle spasms 24.93 9.94 148 90204 251735 90286360
Mast cell activation syndrome 24.88 9.94 17 90335 1577 90536518
Rectosigmoid cancer 24.65 9.94 9 90343 211 90537884
Purple glove syndrome 24.57 9.94 9 90343 213 90537882
Depression 24.56 9.94 187 90165 300414 90237681
COVID-19 24.56 9.94 267 90085 168576 90369519
Skin ulcer 24.51 9.94 107 90245 49968 90488127
Back injury 24.41 9.94 8 90344 46614 90491481
Dermatitis exfoliative generalised 24.40 9.94 29 90323 5564 90532531
Synovial fluid analysis 24.05 9.94 21 90331 2797 90535298
Gastrointestinal motility disorder 24.00 9.94 30 90322 6061 90532034
Adenocarcinoma gastric 23.69 9.94 12 90340 637 90537458
Herpes zoster 23.69 9.94 36 90316 94608 90443487
Malnutrition 23.43 9.94 55 90297 18503 90519592
Campylobacter colitis 23.42 9.94 6 90346 39 90538056
Glomerular filtration rate increased 23.13 9.94 18 90334 2042 90536053
Hypocapnia 23.10 9.94 11 90341 510 90537585
Clinically isolated syndrome 23.04 9.94 6 90346 42 90538053
Hemianopia 22.96 9.94 18 90334 2064 90536031
Vitreous detachment 22.92 9.94 19 90333 2359 90535736
Cardiovascular disorder 22.80 9.94 45 90307 13447 90524648
Burning sensation 22.74 9.94 124 90228 63328 90474767
Abdominal discomfort 22.69 9.94 337 90015 476991 90061104
Finger deformity 22.63 9.94 3 90349 32894 90505201
Gastric disorder 22.58 9.94 79 90273 33305 90504790
Fluid retention 22.54 9.94 33 90319 88058 90450037
Allergy to chemicals 22.51 9.94 23 90329 3731 90534364
Type I hypersensitivity 22.31 9.94 24 90328 4131 90533964
Rectal cancer metastatic 22.23 9.94 9 90343 281 90537814
Eczema 22.20 9.94 108 90244 52762 90485333
Metabolic acidosis 22.15 9.94 112 90240 55564 90482531
Aspartate aminotransferase increased 22.13 9.94 177 90175 102760 90435335
Vitamin B12 deficiency 22.05 9.94 32 90320 7454 90530641
Bursitis 22.04 9.94 63 90289 131591 90406504
Newborn persistent pulmonary hypertension 22.00 9.94 9 90343 289 90537806
Parosmia 21.97 9.94 31 90321 7038 90531057
Platelet count decreased 21.87 9.94 67 90285 136902 90401193
Blood pressure increased 21.77 9.94 296 90056 196921 90341174
Postoperative wound infection 21.75 9.94 44 90308 13382 90524713
Steroid dependence 21.60 9.94 18 90334 2251 90535844
Blood pressure systolic increased 21.57 9.94 115 90237 58230 90479865
Gastrointestinal haemorrhage 21.53 9.94 159 90193 90089 90448006
Genotype drug resistance test positive 21.51 9.94 10 90342 439 90537656
Meningitis aseptic 21.50 9.94 30 90322 6743 90531352
Vulvovaginal burning sensation 21.47 9.94 19 90333 2576 90535519
Neonatal respiratory failure 21.38 9.94 9 90343 311 90537784
Blood pressure diastolic decreased 21.28 9.94 67 90285 26759 90511336
General physical health deterioration 21.20 9.94 239 90113 354876 90183219
Ear pain 21.06 9.94 16 90336 57686 90480409
Therapy interrupted 20.85 9.94 12 90340 50096 90487999
Synovial cyst 20.84 9.94 40 90312 11712 90526383
Systemic lupus erythematosus rash 20.79 9.94 18 90334 2371 90535724
Rheumatoid factor increased 20.65 9.94 18 90334 2393 90535702
Hypergastrinaemia 20.50 9.94 7 90345 134 90537961
Deja vu 20.45 9.94 7 90345 135 90537960
Erdheim-Chester disease 20.39 9.94 6 90346 69 90538026
Syncope 20.32 9.94 212 90140 132451 90405644
Rash 20.24 9.94 622 89730 795478 89742617
Hepatitis cholestatic 20.17 9.94 33 90319 8528 90529567
Wrong technique in product usage process 20.15 9.94 25 90327 71546 90466549
Anaemia 20.14 9.94 477 89875 352325 90185770
IIIrd nerve paresis 20.12 9.94 7 90345 142 90537953
Throat irritation 20.11 9.94 99 90253 48596 90489499
Major depression 20.11 9.94 36 90316 9999 90528096
Injection site swelling 20.10 9.94 18 90334 59821 90478274
Blood pressure fluctuation 19.85 9.94 104 90248 52309 90485786
Thrombocytopenia 19.76 9.94 305 90047 208420 90329675
Glossitis 19.75 9.94 21 90331 3566 90534529
Pain in extremity 19.75 9.94 323 90029 450206 90087889
Congenital osteodystrophy 19.72 9.94 5 90347 31 90538064
Vulvovaginal pruritus 19.59 9.94 22 90330 3971 90534124
Glycosylated haemoglobin increased 19.52 9.94 46 90306 15516 90522579
Epiglottic erythema 19.51 9.94 6 90346 81 90538014
Gait disturbance 19.46 9.94 166 90186 260330 90277765
Pulmonary hypertension 19.41 9.94 89 90263 42434 90495661
Paraesthesia 19.39 9.94 158 90194 250168 90287927
Tri-iodothyronine free decreased 19.38 9.94 9 90343 394 90537701
Myelosuppression 19.38 9.94 15 90337 53576 90484519
Hypopnoea 19.37 9.94 23 90329 4408 90533687
Tenosynovitis 19.30 9.94 44 90308 14523 90523572
Skin lesion 19.18 9.94 81 90271 37284 90500811
Joint noise 19.18 9.94 25 90327 5265 90532830
Axonal neuropathy 19.12 9.94 13 90339 1196 90536899
Macular degeneration 19.05 9.94 7 90345 37963 90500132
Cardiac disorder 18.96 9.94 109 90243 56763 90481332
Laboratory test abnormal 18.93 9.94 9 90343 41845 90496250
CSF protein increased 18.84 9.94 11 90341 775 90537320
Tongue injury 18.81 9.94 10 90342 587 90537508
Persistent depressive disorder 18.67 9.94 13 90339 1244 90536851
Infusion site thrombosis 18.60 9.94 7 90345 179 90537916
Onychomycosis 18.56 9.94 7 90345 37369 90500726
Injection site haemorrhage 18.51 9.94 3 90349 28315 90509780
Blood potassium increased 18.51 9.94 54 90298 20695 90517400
Immunodeficiency 18.50 9.94 10 90342 43224 90494871
Schizophreniform disorder 18.45 9.94 6 90346 98 90537997
Eosinophilic fasciitis 18.14 9.94 7 90345 192 90537903
Therapeutic product effect decreased 18.10 9.94 183 90169 277388 90260707
Rhinalgia 18.03 9.94 17 90335 2501 90535594
Left ventricular dysfunction 18.01 9.94 43 90309 14626 90523469
Scleritis 17.94 9.94 24 90328 5184 90532911
Thymus disorder 17.86 9.94 8 90344 322 90537773
No adverse event 17.85 9.94 25 90327 67957 90470138
Tachycardia paroxysmal 17.77 9.94 8 90344 326 90537769
Genital infection female 17.76 9.94 6 90346 111 90537984
Odynophagia 17.56 9.94 32 90320 9011 90529084
Antipsychotic drug level above therapeutic 17.54 9.94 13 90339 1371 90536724
Musculoskeletal stiffness 17.52 9.94 200 90152 296332 90241763
Dysplasia 17.46 9.94 13 90339 1381 90536714
Junctional ectopic tachycardia 17.43 9.94 7 90345 214 90537881
Spinal disorder 17.43 9.94 37 90315 11642 90526453
Hyponatraemic seizure 17.37 9.94 9 90343 501 90537594
Neck pain 17.32 9.94 57 90295 113906 90424189
Underdose 17.26 9.94 17 90335 54000 90484095
Vertigo 17.23 9.94 124 90228 69687 90468408
Nephrosclerosis 17.15 9.94 12 90340 1157 90536938
Coma acidotic 17.14 9.94 6 90346 124 90537971
Injection site pruritus 17.13 9.94 17 90335 53817 90484278
Hypoosmolar state 17.07 9.94 7 90345 226 90537869
Oesophageal dilatation 17.06 9.94 9 90343 520 90537575
Influenza 17.03 9.94 213 90139 139051 90399044
Fibromyalgia 16.99 9.94 128 90224 206141 90331954
Surgery 16.96 9.94 12 90340 44875 90493220
Crepitations 16.78 9.94 31 90321 8821 90529274
Synovial disorder 16.72 9.94 18 90334 3100 90534995
Idiosyncratic drug reaction 16.70 9.94 11 90341 960 90537135
Headache 16.67 9.94 1034 89318 861712 89676383
Cardiogenic shock 16.64 9.94 58 90294 24410 90513685
Diabetic ketosis 16.57 9.94 9 90343 552 90537543
Crystalluria 16.55 9.94 9 90343 553 90537542
Arterial spasm 16.43 9.94 5 90347 65 90538030
Renal impairment 16.40 9.94 169 90183 105252 90432843
Gamma-glutamyltransferase increased 16.27 9.94 78 90274 37874 90500221
Back disorder 16.13 9.94 3 90349 25628 90512467
Oxygen saturation decreased 16.10 9.94 171 90181 107312 90430783
Disease progression 16.03 9.94 91 90261 156524 90381571
Calcium metabolism disorder 16.00 9.94 6 90346 152 90537943
Congenital bowing of long bones 15.96 9.94 5 90347 72 90538023
Infusion site scar 15.92 9.94 9 90343 597 90537498
Febrile bone marrow aplasia 15.88 9.94 32 90320 9706 90528389
Asthmatic crisis 15.84 9.94 14 90338 1896 90536199
Antinuclear antibody positive 15.83 9.94 31 90321 9210 90528885
Blood HIV RNA increased 15.81 9.94 10 90342 814 90537281
Troponin T increased 15.71 9.94 13 90339 1610 90536485
Muscle haemorrhage 15.68 9.94 18 90334 3328 90534767
Breath sounds abnormal 15.65 9.94 42 90310 15344 90522751
Wheezing 15.50 9.94 157 90195 237923 90300172
Off label use 15.42 9.94 921 89431 1101331 89436764
Epiglottic oedema 15.40 9.94 6 90346 169 90537926
Conjunctivitis 15.38 9.94 60 90292 26646 90511449
Uveal melanoma 15.36 9.94 4 90348 28 90538067
Abdominal pain 15.28 9.94 509 89843 395212 90142883
Throat clearing 15.24 9.94 19 90333 3828 90534267
Premature separation of placenta 15.13 9.94 15 90337 2347 90535748
Carnitine deficiency 15.11 9.94 6 90346 178 90537917
Foramen magnum stenosis 14.95 9.94 6 90346 183 90537912
Osteoarthritis 14.94 9.94 124 90228 195606 90342489
Gingival pain 14.89 9.94 31 90321 9621 90528474
Respiratory acidosis 14.85 9.94 28 90324 8091 90530004
Face oedema 14.76 9.94 54 90298 23264 90514831
Nephritis allergic 14.73 9.94 7 90345 323 90537772
Therapy cessation 14.72 9.94 9 90343 36352 90501743
Renal tubular atrophy 14.61 9.94 10 90342 930 90537165
Memory impairment 14.59 9.94 126 90226 197118 90340977
Placental calcification 14.57 9.94 4 90348 35 90538060
Sprue-like enteropathy 14.49 9.94 10 90342 943 90537152
Conversion disorder 14.44 9.94 14 90338 2132 90535963
Distal intestinal obstruction syndrome 14.37 9.94 8 90344 515 90537580
Salpingo-oophorectomy unilateral 14.35 9.94 10 90342 958 90537137
Chemotherapeutic drug level increased 14.18 9.94 6 90346 210 90537885
Sinusitis 14.04 9.94 249 90103 342839 90195256
Multiple sclerosis relapse 13.97 9.94 19 90333 52286 90485809
Drug clearance decreased 13.95 9.94 13 90339 1885 90536210
Incorrect route of product administration 13.92 9.94 18 90334 50608 90487487
Lip oedema 13.91 9.94 20 90332 4619 90533476
Pericardial effusion 13.89 9.94 73 90279 36760 90501335
Granuloma skin 13.86 9.94 32 90320 10648 90527447
Diarrhoea 13.85 9.94 1101 89251 938089 89600006
Hyperemesis gravidarum 13.84 9.94 9 90343 769 90537326
Hyporesponsive to stimuli 13.70 9.94 12 90340 1605 90536490
Treatment noncompliance 13.60 9.94 19 90333 51708 90486387
Pleural infection 13.57 9.94 6 90346 234 90537861
Dactylitis 13.57 9.94 18 90334 3855 90534240
Posterior reversible encephalopathy syndrome 13.53 9.94 51 90301 22288 90515807
Completed suicide 13.42 9.94 87 90265 144971 90393124
Blood pressure systolic decreased 13.41 9.94 29 90323 9241 90528854
Aortic dilatation 13.38 9.94 10 90342 1068 90537027
Anal inflammation 13.33 9.94 7 90345 401 90537694
Gastric antral vascular ectasia 13.32 9.94 9 90343 820 90537275
Hyperlipasaemia 13.30 9.94 9 90343 822 90537273
Mitral valve incompetence 13.30 9.94 51 90301 22473 90515622
Electrocardiogram repolarisation abnormality 13.27 9.94 11 90341 1365 90536730
Tachycardia 13.27 9.94 226 90126 157447 90380648
Adverse event 13.25 9.94 66 90286 117352 90420743
Vitamin B12 decreased 13.23 9.94 21 90331 5289 90532806
Sinus bradycardia 13.14 9.94 42 90310 16910 90521185
Urinary tract stoma complication 13.07 9.94 4 90348 53 90538042
Vascular purpura 12.96 9.94 12 90340 1726 90536369
Myelodysplastic syndrome 12.89 9.94 48 90304 20855 90517240
Paranasal sinus inflammation 12.88 9.94 8 90344 631 90537464
Hypercapnic coma 12.83 9.94 6 90346 267 90537828
Tongue oedema 12.81 9.94 21 90331 5433 90532662
Injection site extravasation 12.80 9.94 28 90324 8991 90529104
Oesophagitis 12.71 9.94 42 90310 17207 90520888
Acute coronary syndrome 12.53 9.94 31 90321 10782 90527313
Blood thyroid stimulating hormone increased 12.52 9.94 28 90324 9127 90528968
Nasal turbinate hypertrophy 12.46 9.94 9 90343 912 90537183
Female sterilisation 12.39 9.94 8 90344 675 90537420
Respiratory disorder 12.39 9.94 29 90323 64787 90473308
Streptococcal endocarditis 12.39 9.94 5 90347 155 90537940
Tetany 12.28 9.94 14 90338 2570 90535525
Pulmonary artery stenosis 12.24 9.94 6 90346 297 90537798
Product use in unapproved indication 12.22 9.94 249 90103 335987 90202108
Sinobronchitis 12.20 9.94 8 90344 693 90537402
Abortion spontaneous 12.19 9.94 22 90330 54034 90484061
Coombs positive haemolytic anaemia 12.13 9.94 7 90345 483 90537612
Cold type haemolytic anaemia 12.07 9.94 6 90346 306 90537789
Epilepsy congenital 12.06 9.94 3 90349 17 90538078
Bone disorder 12.05 9.94 4 90348 23116 90514979
Supraventricular extrasystoles 12.03 9.94 20 90332 5237 90532858
Retinal artery occlusion 11.99 9.94 13 90339 2258 90535837
Thyroid disorder 11.95 9.94 42 90310 17743 90520352
Toxic epidermal necrolysis 11.94 9.94 64 90288 32464 90505631
Vascular access site pain 11.92 9.94 7 90345 499 90537596
Nausea 11.89 9.94 1272 89080 1109044 89429051
Tongue discolouration 11.88 9.94 16 90336 3477 90534618
Lupus-like syndrome 11.82 9.94 19 90333 48827 90489268
Post-traumatic stress disorder 11.81 9.94 23 90329 6805 90531290
Dyspnoea exertional 11.77 9.94 117 90235 72171 90465924
Pulmonary sarcoidosis 11.74 9.94 10 90342 1289 90536806
Flatulence 11.71 9.94 76 90276 41291 90496804
Drug resistance 11.69 9.94 8 90344 30441 90507654
Non-economic loss 11.65 9.94 3 90349 20 90538075
Phlebitis 11.62 9.94 24 90328 7406 90530689
Protein-losing gastroenteropathy 11.61 9.94 6 90346 332 90537763
Eye haemorrhage 11.60 9.94 29 90323 10151 90527944
Jugular vein thrombosis 11.57 9.94 16 90336 3565 90534530
Altered state of consciousness 11.55 9.94 62 90290 31470 90506625
Renal vascular thrombosis 11.50 9.94 4 90348 81 90538014
Toxic shock syndrome 11.46 9.94 9 90343 1035 90537060
Nail avulsion 11.39 9.94 6 90346 346 90537749
Airway remodelling 11.32 9.94 4 90348 85 90538010
Hypofibrinogenaemia 11.28 9.94 10 90342 1360 90536735
Red blood cell sedimentation rate abnormal 11.26 9.94 5 90347 24199 90513896
Procedural pain 11.24 9.94 10 90342 33350 90504745
Injection site rash 11.24 9.94 5 90347 24168 90513927
Tongue coated 11.20 9.94 11 90341 1702 90536393
Hyperglycaemia 11.15 9.94 88 90264 50882 90487213
Illness 11.12 9.94 43 90309 81926 90456169
Osteoporosis postmenopausal 11.06 9.94 6 90346 367 90537728
Shock haemorrhagic 11.05 9.94 32 90320 12213 90525882
Hypercalcaemia 11.00 9.94 65 90287 34175 90503920
Iliotibial band syndrome 10.95 9.94 6 90346 374 90537721
Potentiating drug interaction 10.95 9.94 20 90332 5642 90532453
Drug ineffective for unapproved indication 10.92 9.94 108 90244 66536 90471559
Vulvovaginal erythema 10.87 9.94 7 90345 588 90537507
Cholestatic liver injury 10.85 9.94 16 90336 3781 90534314
Paranasal sinus discomfort 10.84 9.94 21 90331 6189 90531906
Retroperitoneal haematoma 10.81 9.94 15 90337 3353 90534742
Hepatitis 10.81 9.94 113 90239 70626 90467469
Vaginal discharge 10.81 9.94 3 90349 19461 90518634
Diabetes mellitus inadequate control 10.78 9.94 42 90310 18642 90519453
Sleep disorder due to a general medical condition 10.77 9.94 79 90273 44659 90493436
Sputum increased 10.76 9.94 14 90338 2943 90535152
Food allergy 10.74 9.94 6 90346 25472 90512623
Neutrophil count increased 10.71 9.94 43 90309 19347 90518748
Dyslipidaemia 10.70 9.94 28 90324 10079 90528016
Chronic cutaneous lupus erythematosus 10.68 9.94 8 90344 858 90537237
Insomnia 10.67 9.94 252 90100 333222 90204873
Peripheral swelling 10.65 9.94 322 90030 412784 90125311
Spontaneous haematoma 10.64 9.94 9 90343 1149 90536946
Jaundice 10.63 9.94 62 90290 32455 90505640
Skin necrosis 10.53 9.94 39 90313 16902 90521193
Herpes simplex test positive 10.53 9.94 6 90346 404 90537691
Delirium 10.48 9.94 61 90291 104298 90433797
Kidney fibrosis 10.44 9.94 12 90340 2222 90535873
Adrenal insufficiency 10.40 9.94 58 90294 29863 90508232
Malignant sweat gland neoplasm 10.39 9.94 4 90348 109 90537986
Aspartate aminotransferase abnormal 10.36 9.94 13 90339 2636 90535459
Parophthalmia 10.35 9.94 6 90346 417 90537678
Creatinine renal clearance decreased 10.33 9.94 3 90349 18896 90519199
Poisoning deliberate 10.29 9.94 38 90314 16448 90521647
Pulmonary toxicity 10.27 9.94 30 90322 11501 90526594
Full blood count abnormal 10.21 9.94 67 90285 36530 90501565
Cushingoid 10.20 9.94 28 90324 10367 90527728
Defaecation disorder 10.18 9.94 8 90344 921 90537174
Brain contusion 10.16 9.94 7 90345 658 90537437
Pneumonia cryptococcal 10.16 9.94 9 90343 1222 90536873
Oesophageal motility disorder 10.15 9.94 7 90345 659 90537436
Demyelination 10.14 9.94 24 90328 8116 90529979
Varicose veins vulval 10.13 9.94 4 90348 117 90537978
Peritonectomy 10.08 9.94 3 90349 36 90538059
Mixed liver injury 10.07 9.94 23 90329 7600 90530495
Caesarean section 10.06 9.94 3 90349 18574 90519521

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypomagnesaemia 222.39 11.07 221 51920 28267 42540927
Acute kidney injury 182.80 11.07 909 51232 366428 42202766
Death 147.70 11.07 218 51923 470967 42098227
Tubulointerstitial nephritis 137.51 11.07 181 51960 31367 42537827
Chronic kidney disease 136.18 11.07 223 51918 47018 42522176
Hypocalcaemia 119.14 11.07 165 51976 30008 42539186
Migraine 101.87 11.07 140 52001 25274 42543920
Burns second degree 98.75 11.07 72 52069 6024 42563170
Catarrh 97.65 11.07 71 52070 5915 42563279
Cardiospasm 96.49 11.07 47 52094 1860 42567334
Nightmare 93.13 11.07 133 52008 24879 42544315
Steroid dependence 90.32 11.07 71 52070 6651 42562543
Tinnitus 89.37 11.07 141 52000 28797 42540397
Palmoplantar keratoderma 89.06 11.07 47 52094 2207 42566987
Hypopnoea 88.53 11.07 75 52066 7807 42561387
Occult blood 87.48 11.07 36 52105 950 42568244
Systemic lupus erythematosus 87.28 11.07 80 52061 9244 42559950
Parosmia 83.97 11.07 72 52069 7619 42561575
Gingival pain 83.67 11.07 75 52066 8419 42560775
Pruritus genital 82.12 11.07 47 52094 2592 42566602
Palpitations 81.31 11.07 187 51954 50610 42518584
Product dose omission issue 80.95 11.07 44 52097 154321 42414873
Drug ineffective 79.68 11.07 450 51691 629747 41939447
Cholestasis 77.44 11.07 142 51999 32737 42536457
Drug interaction 77.41 11.07 575 51566 266424 42302770
Rhinitis 77.38 11.07 84 52057 11893 42557301
Sleep terror 75.05 11.07 46 52095 2880 42566314
Hepatic cytolysis 73.67 11.07 124 52017 26720 42542474
Systolic dysfunction 73.60 11.07 46 52095 2982 42566212
Tension headache 73.40 11.07 48 52093 3366 42565828
Hepatojugular reflux 71.34 11.07 28 52113 651 42568543
Immunisation 69.71 11.07 33 52108 1225 42567969
Hypokalaemia 68.31 11.07 218 51923 71503 42497691
Inappropriate antidiuretic hormone secretion 67.61 11.07 92 52049 16449 42552745
Electrocardiogram Q wave abnormal 66.78 11.07 25 52116 509 42568685
Neuropsychiatric lupus 65.06 11.07 16 52125 67 42569127
Accidental overdose 63.76 11.07 120 52021 28210 42540984
Pancreatitis acute 63.28 11.07 132 52009 33432 42535762
Pericarditis 63.04 11.07 80 52061 13364 42555830
Atrial tachycardia 62.79 11.07 47 52094 4093 42565101
Drug abuse 62.41 11.07 25 52116 104746 42464448
Carotid artery occlusion 62.25 11.07 47 52094 4147 42565047
Anosmia 61.75 11.07 51 52090 5125 42564069
Facial pain 59.41 11.07 46 52095 4214 42564980
Cardiac murmur 58.29 11.07 75 52066 12700 42556494
Hypergastrinaemia 57.45 11.07 18 52123 208 42568986
Eczema 57.33 11.07 128 52013 33958 42535236
Hyponatraemia 55.81 11.07 259 51882 101203 42467991
Toxic skin eruption 55.56 11.07 76 52065 13654 42555540
Acquired haemophilia 55.27 11.07 31 52110 1644 42567550
Alcohol poisoning 54.03 11.07 56 52085 7518 42561676
Febrile bone marrow aplasia 53.23 11.07 64 52077 10117 42559077
Degenerative mitral valve disease 52.86 11.07 18 52123 275 42568919
Hepatocellular injury 50.46 11.07 98 52043 23580 42545614
Helicobacter gastritis 47.20 11.07 26 52115 1331 42567863
Impaired work ability 46.04 11.07 65 52076 12026 42557168
Swollen tongue 44.18 11.07 87 52054 21144 42548050
Vertigo 42.85 11.07 115 52026 34232 42534962
Ventricular arrhythmia 42.25 11.07 45 52096 6234 42562960
Ventricular hypokinesia 42.25 11.07 47 52094 6837 42562357
Pulmonary vascular disorder 41.06 11.07 19 52122 669 42568525
Anaemia macrocytic 40.28 11.07 34 52107 3521 42565673
Eosinophilia 39.89 11.07 109 52032 32790 42536404
Carotid arteriosclerosis 38.81 11.07 28 52113 2304 42566890
Agranulocytosis 38.70 11.07 103 52038 30509 42538685
Lactic acidosis 38.10 11.07 132 52009 45129 42524065
Inferior vena cava dilatation 37.89 11.07 19 52122 801 42568393
Nicotine dependence 37.85 11.07 18 52123 675 42568519
Rectal haemorrhage 37.78 11.07 140 52001 49466 42519728
Pain of skin 37.75 11.07 48 52093 8032 42561162
Tubulointerstitial nephritis and uveitis syndrome 36.54 11.07 11 52130 110 42569084
Tumour fistulisation 36.36 11.07 11 52130 112 42569082
Colitis ulcerative 36.10 11.07 91 52050 26084 42543110
Cardiac failure congestive 36.04 11.07 31 52110 85571 42483623
Drug reaction with eosinophilia and systemic symptoms 35.67 11.07 123 52018 41952 42527242
Medication error 35.48 11.07 105 52036 33049 42536145
Bronchiectasis 35.29 11.07 72 52069 17947 42551247
Ischaemic stroke 34.62 11.07 81 52060 22152 42547042
Frequent bowel movements 34.44 11.07 79 52062 21328 42547866
Eye injury 34.09 11.07 19 52122 995 42568199
Administration site inflammation 34.06 11.07 9 52132 53 42569141
Ventricular tachycardia 33.69 11.07 97 52044 30063 42539131
Impaired quality of life 33.08 11.07 61 52080 14116 42555078
Rash maculo-papular 32.99 11.07 111 52030 37392 42531802
Troponin T increased 32.35 11.07 27 52114 2753 42566441
White blood cell count decreased 31.62 11.07 54 52087 110342 42458852
Physical examination abnormal 31.53 11.07 14 52127 447 42568747
Mitral valve incompetence 31.25 11.07 65 52076 16424 42552770
Pneumonia 30.16 11.07 351 51790 421798 42147396
Cardiac aneurysm 29.99 11.07 18 52123 1085 42568109
Cross sensitivity reaction 29.92 11.07 21 52120 1654 42567540
Pericardial disease 29.87 11.07 14 52127 508 42568686
Eosinophilic colitis 29.61 11.07 12 52129 304 42568890
Pulmonary valve disease 29.49 11.07 13 52128 408 42568786
Rash papular 29.06 11.07 52 52089 11759 42557435
Hypophosphataemic osteomalacia 28.88 11.07 10 52131 161 42569033
Toxicity to various agents 28.53 11.07 164 51977 228972 42340222
Muscle twitching 27.88 11.07 51 52090 11729 42557465
Subarachnoid haemorrhage 27.37 11.07 57 52084 14415 42554779
No adverse event 27.31 11.07 7 52134 39014 42530180
Allergic keratitis 26.75 11.07 6 52135 15 42569179
Dysgeusia 26.45 11.07 97 52044 34092 42535102
Dyspnoea at rest 26.06 11.07 29 52112 4220 42564974
Injection site pain 25.48 11.07 20 52121 57778 42511416
Granulomatous rosacea 25.38 11.07 9 52132 156 42569038
Hyperhidrosis 25.03 11.07 193 51948 90319 42478875
Aortic valve incompetence 24.63 11.07 35 52106 6513 42562681
Blindness cortical 24.47 11.07 12 52129 482 42568712
Arthritis 24.30 11.07 109 52032 41956 42527238
Infective exacerbation of chronic obstructive airways disease 24.18 11.07 20 52121 2013 42567181
Eye pruritus 24.02 11.07 47 52094 11365 42557829
Acute generalised exanthematous pustulosis 23.97 11.07 40 52101 8555 42560639
Renal injury 23.96 11.07 49 52092 12231 42556963
Colitis microscopic 23.86 11.07 24 52117 3109 42566085
Helicobacter test positive 23.84 11.07 14 52127 810 42568384
COVID-19 pneumonia 23.64 11.07 69 52072 21544 42547650
Ventricular enlargement 23.52 11.07 13 52128 670 42568524
Hospitalisation 23.52 11.07 34 52107 74296 42494898
Weight increased 23.25 11.07 62 52079 107921 42461273
Blindness 23.24 11.07 61 52080 17917 42551277
Nasopharyngitis 23.22 11.07 42 52099 83954 42485240
Pharyngeal necrosis 22.90 11.07 7 52134 74 42569120
Therapeutic product effect incomplete 22.89 11.07 32 52109 70907 42498287
Cardiac discomfort 22.59 11.07 13 52128 724 42568470
Diplopia 22.36 11.07 65 52076 20251 42548943
Gastroenteritis eosinophilic 22.25 11.07 9 52132 227 42568967
Thrombosis 22.01 11.07 31 52110 68480 42500714
Myelosuppression 21.97 11.07 11 52130 40450 42528744
Chronic obstructive pulmonary disease 21.87 11.07 27 52114 63087 42506107
Completed suicide 21.83 11.07 54 52087 96411 42472783
Papillary renal cell carcinoma 21.78 11.07 10 52131 346 42568848
Swelling 21.76 11.07 21 52120 54864 42514330
Drug ineffective for unapproved indication 21.60 11.07 15 52126 46148 42523046
Neuropathy peripheral 21.54 11.07 59 52082 101794 42467400
Platelet count decreased 21.36 11.07 92 52049 138489 42430705
Rhabdomyolysis 20.81 11.07 165 51976 77854 42491340
Urticaria papular 20.80 11.07 7 52134 103 42569091
Sensitisation 20.58 11.07 9 52132 277 42568917
Abdominal pain upper 20.57 11.07 172 51969 82437 42486757
Photosensitivity reaction 20.57 11.07 47 52094 12655 42556539
Therapy non-responder 20.48 11.07 21 52120 53338 42515856
Haematochezia 20.48 11.07 132 52009 58304 42510890
Type III immune complex mediated reaction 19.83 11.07 11 52130 571 42568623
COVID-19 19.80 11.07 223 51918 115725 42453469
Spontaneous haematoma 19.65 11.07 12 52129 746 42568448
Normocytic anaemia 19.55 11.07 23 52118 3554 42565640
Treatment failure 19.46 11.07 29 52112 62595 42506599
Physical deconditioning 19.39 11.07 19 52122 2386 42566808
Interstitial lung disease 19.35 11.07 163 51978 78299 42490895
Sedation 19.15 11.07 81 52060 30394 42538800
Peripheral venous disease 19.10 11.07 21 52120 3015 42566179
Vascular purpura 19.00 11.07 18 52123 2168 42567026
Overlap syndrome 18.96 11.07 9 52132 336 42568858
Cardiac failure 18.92 11.07 207 51934 106649 42462545
Eructation 18.71 11.07 28 52113 5458 42563736
Adverse drug reaction 18.70 11.07 93 52048 37341 42531853
Gastric polyps 18.61 11.07 16 52125 1699 42567495
Tumour perforation 18.20 11.07 10 52131 509 42568685
Intentional product use issue 18.12 11.07 150 51991 71683 42497511
Cardiac arrest 17.82 11.07 71 52070 109249 42459945
Occupational exposure to air contaminants 17.74 11.07 7 52134 165 42569029
Brief psychotic disorder with marked stressors 17.72 11.07 8 52133 266 42568928
Angiopathy 17.71 11.07 27 52114 5350 42563844
Disturbance in attention 17.71 11.07 78 52063 29788 42539406
Rhinovirus infection 17.63 11.07 30 52111 6518 42562676
Antiphospholipid antibodies positive 17.61 11.07 9 52132 395 42568799
Therapy interrupted 17.61 11.07 3 52138 22247 42546947
Renal failure 17.60 11.07 260 51881 143466 42425728
Carotid artery stenosis 17.49 11.07 27 52114 5409 42563785
Dizziness 17.45 11.07 208 51933 249046 42320148
Angioedema 17.45 11.07 100 52041 42377 42526817
Fixed eruption 17.24 11.07 18 52123 2436 42566758
High frequency ablation 17.21 11.07 7 52134 179 42569015
Dermatomyositis 17.16 11.07 15 52126 1628 42567566
Circumoral oedema 17.08 11.07 6 52135 101 42569093
Duodenitis 17.04 11.07 27 52114 5529 42563665
Craniotabes 16.83 11.07 4 52137 14 42569180
Prostate cancer 16.65 11.07 18 52123 44625 42524569
Ventricular fibrillation 16.64 11.07 8 52133 30115 42539079
Hypoparathyroidism secondary 16.59 11.07 7 52134 197 42568997
Myoglobinaemia 16.46 11.07 7 52134 201 42568993
Subacute cutaneous lupus erythematosus 16.38 11.07 14 52127 1474 42567720
Laboratory test abnormal 16.32 11.07 4 52137 22974 42546220
Abdominal discomfort 16.31 11.07 152 51989 75103 42494091
Off label use 16.28 11.07 628 51513 637707 41931487
Mitral valve disease 16.20 11.07 14 52127 1496 42567698
Dehiscence 16.17 11.07 10 52131 636 42568558
Vasculitis 15.78 11.07 54 52087 18340 42550854
Hyperkalaemia 15.72 11.07 159 51982 80299 42488895
Device related bacteraemia 15.71 11.07 10 52131 669 42568525
Left ventricular hypertrophy 15.67 11.07 35 52106 9284 42559910
Heat stroke 15.53 11.07 12 52129 1096 42568098
Wheezing 15.49 11.07 27 52114 54754 42514440
Creatinine renal clearance abnormal 15.45 11.07 8 52133 361 42568833
End stage renal disease 15.44 11.07 50 52091 16508 42552686
Paresis 15.24 11.07 17 52124 2479 42566715
Oesophageal ulcer haemorrhage 15.17 11.07 8 52133 375 42568819
Hypoparathyroidism 15.11 11.07 10 52131 715 42568479
Phaeochromocytoma malignant 15.08 11.07 5 52136 70 42569124
Spinal osteoarthritis 15.03 11.07 33 52108 8653 42560541
Cerebellar syndrome 15.01 11.07 18 52123 2837 42566357
Deep vein thrombosis 14.99 11.07 152 51989 76805 42492389
Full blood count abnormal 14.94 11.07 9 52132 29867 42539327
Radiation necrosis 14.81 11.07 7 52134 259 42568935
Capillary permeability increased 14.67 11.07 4 52137 27 42569167
Sinusitis 14.60 11.07 22 52119 47270 42521924
Jaundice 14.58 11.07 82 52059 34507 42534687
Contusion 14.50 11.07 18 52123 41967 42527227
Dermatitis bullous 14.49 11.07 32 52109 8424 42560770
Hallucination 14.45 11.07 120 52021 57387 42511807
Hiatus hernia 14.22 11.07 32 52109 8528 42560666
Shock haemorrhagic 14.21 11.07 48 52093 16194 42553000
Preterm premature rupture of membranes 14.19 11.07 5 52136 85 42569109
Cerebral haematoma 14.18 11.07 25 52116 5585 42563609
Food interaction 14.17 11.07 11 52130 1011 42568183
Lip swelling 13.86 11.07 53 52088 19000 42550194
Vitamin B12 deficiency 13.85 11.07 23 52118 4899 42564295
Full blood count decreased 13.80 11.07 4 52137 20556 42548638
Diastolic dysfunction 13.79 11.07 28 52113 6955 42562239
Cognitive disorder 13.74 11.07 80 52061 34092 42535102
Drug-induced liver injury 13.74 11.07 87 52054 38186 42531008
On and off phenomenon 13.74 11.07 19 52122 3448 42565746
Duodenal polyp 13.70 11.07 7 52134 307 42568887
Drug resistance 13.69 11.07 13 52128 34235 42534959
Loss of personal independence in daily activities 13.63 11.07 106 52035 49710 42519484
Respiratory arrest 13.62 11.07 9 52132 28415 42540779
Occupational dermatitis 13.39 11.07 5 52136 101 42569093
Arthropathy 13.35 11.07 10 52131 29587 42539607
Fractured skull depressed 13.29 11.07 4 52137 40 42569154
Drug intolerance 13.25 11.07 52 52089 80372 42488822
Asthma 13.24 11.07 36 52105 62278 42506916
Antibody test abnormal 13.22 11.07 7 52134 331 42568863
Aggression 13.19 11.07 21 52120 44142 42525052
Thrombocytopenia 13.13 11.07 315 51826 189964 42379230
Bacterial infection 13.12 11.07 9 52132 27870 42541324
Electrocardiogram QT prolonged 13.11 11.07 102 52039 47843 42521351
Xerosis 13.01 11.07 10 52131 906 42568288
Drug hypersensitivity 12.96 11.07 70 52071 99319 42469875
Exercise tolerance decreased 12.79 11.07 25 52116 6041 42563153
Insulin autoimmune syndrome 12.71 11.07 8 52133 525 42568669
Sudden death 12.71 11.07 47 52094 16582 42552612
Muscle haemorrhage 12.59 11.07 20 52121 4105 42565089
Benign soft tissue neoplasm 12.55 11.07 5 52136 121 42569073
Hypercalciuria 12.52 11.07 7 52134 369 42568825
Drug delivery device placement 12.40 11.07 5 52136 125 42569069
Metabolic acidosis 12.39 11.07 107 52034 51751 42517443
Incorrect product dosage form administered 12.35 11.07 6 52135 236 42568958
N-terminal prohormone brain natriuretic peptide increased 12.32 11.07 18 52123 3435 42565759
Dermatitis exfoliative generalised 12.28 11.07 24 52117 5800 42563394
Infusion related reaction 12.27 11.07 36 52105 60770 42508424
Blood pressure increased 12.11 11.07 74 52067 101854 42467340
Periorbital oedema 12.10 11.07 21 52120 4636 42564558
Echocardiogram abnormal 12.09 11.07 11 52130 1259 42567935
Serotonin syndrome 12.06 11.07 63 52078 25782 42543412
Postrenal failure 12.05 11.07 8 52133 575 42568619
Miosis 12.00 11.07 40 52101 13406 42555788
Haemoglobin decreased 11.96 11.07 104 52037 132367 42436827
Cataract 11.89 11.07 71 52070 30533 42538661
Fracture delayed union 11.87 11.07 4 52137 59 42569135
Cutaneous vasculitis 11.80 11.07 26 52115 6834 42562360
Pneumobilia 11.77 11.07 5 52136 143 42569051
COVID-19 treatment 11.75 11.07 6 52135 263 42568931
Flushing 11.65 11.07 17 52124 37011 42532183
Face oedema 11.62 11.07 40 52101 13626 42555568
Alopecia 11.42 11.07 68 52073 29208 42539986
Therapeutic product effect decreased 11.34 11.07 19 52122 39131 42530063
Foetal exposure timing unspecified 11.29 11.07 6 52135 286 42568908
Cholesteatoma 11.19 11.07 4 52137 71 42569123
Herpes zoster 11.14 11.07 19 52122 38858 42530336
Musculoskeletal stiffness 11.09 11.07 35 52106 57730 42511464

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute kidney injury 447.06 10.04 1715 130167 633715 109823702
Hypomagnesaemia 416.36 10.04 433 131449 59937 110397480
Carotid artery thrombosis 288.84 10.04 166 131716 9472 110447945
Neurologic neglect syndrome 283.61 10.04 162 131720 9136 110448281
Adjustment disorder 258.68 10.04 161 131721 10634 110446783
Personality disorder 257.07 10.04 171 131711 12666 110444751
Hypocalcaemia 256.89 10.04 352 131530 65014 110392403
Tubulointerstitial nephritis 246.80 10.04 314 131568 53970 110403447
Hemiplegia 236.58 10.04 205 131677 22577 110434840
Cholestasis 224.78 10.04 328 131554 64190 110393227
Cardiospasm 220.27 10.04 111 131771 4856 110452561
Affect lability 212.58 10.04 177 131705 18460 110438957
Palmoplantar keratoderma 211.76 10.04 111 131771 5276 110452141
Coordination abnormal 210.95 10.04 201 131681 25027 110432390
Hyponatraemia 206.83 10.04 650 131232 217003 110240414
Pruritus genital 197.22 10.04 113 131769 6409 110451008
Chronic kidney disease 196.81 10.04 338 131544 75953 110381464
Motor dysfunction 193.79 10.04 189 131693 24217 110433200
Anti-cyclic citrullinated peptide antibody positive 193.34 10.04 5 131877 181979 110275438
Pemphigus 193.00 10.04 17 131865 214553 110242864
Sleep terror 182.61 10.04 108 131774 6502 110450915
Death 180.65 10.04 350 131532 698519 109758898
Glossodynia 176.32 10.04 27 131855 221977 110235440
Wound 176.29 10.04 33 131849 234404 110223013
Sensory loss 173.81 10.04 168 131714 21289 110436128
Duodenal ulcer perforation 171.53 10.04 10 131872 177690 110279727
Aphasia 166.32 10.04 272 131610 58725 110398692
Hand deformity 165.93 10.04 30 131852 218476 110238941
Atrial tachycardia 161.78 10.04 113 131769 9065 110448352
Drug interaction 160.93 10.04 1084 130798 499099 109958318
Tension headache 157.02 10.04 113 131769 9505 110447912
Inappropriate antidiuretic hormone secretion 155.74 10.04 197 131685 33654 110423763
Carotid artery occlusion 155.29 10.04 112 131770 9453 110447964
Folliculitis 154.31 10.04 12 131870 167641 110289776
Helicobacter infection 154.24 10.04 18 131864 181859 110275558
Angioedema 154.20 10.04 354 131528 98146 110359271
Psoriatic arthropathy 153.83 10.04 25 131857 196736 110260681
Hepatic cytolysis 152.74 10.04 252 131630 54801 110402616
Palpitations 150.75 10.04 475 131407 158737 110298680
Sensitisation 150.37 10.04 81 131801 4070 110453347
Immunisation 149.61 10.04 74 131808 3109 110454308
Tinnitus 149.33 10.04 263 131619 60277 110397140
Anosmia 145.47 10.04 120 131762 12352 110445065
Swelling 142.87 10.04 125 131757 350916 110106501
Irritable bowel syndrome 139.88 10.04 16 131866 164199 110293218
Muscle injury 138.77 10.04 7 131875 140800 110316617
Injury 135.31 10.04 24 131858 177241 110280176
Hemiparesis 134.15 10.04 210 131672 43693 110413724
Drug ineffective 133.15 10.04 1168 130714 1519372 108938045
Swollen tongue 132.11 10.04 249 131633 60113 110397304
Synovitis 131.70 10.04 82 131800 274010 110183407
Product dose omission issue 129.23 10.04 116 131766 321666 110135751
Loss of employment 128.87 10.04 68 131814 3276 110454141
Eating disorder 125.49 10.04 169 131713 30689 110426728
Impaired work ability 125.12 10.04 156 131726 26263 110431154
Hepatocellular injury 124.90 10.04 220 131662 50422 110406995
Burns second degree 119.75 10.04 88 131794 7645 110449772
Catarrh 119.33 10.04 86 131796 7249 110450168
Polycystic ovaries 118.64 10.04 73 131809 4723 110452694
C-reactive protein abnormal 117.36 10.04 10 131872 129685 110327732
Pancreatitis acute 113.00 10.04 233 131649 60041 110397376
Muscle spasticity 111.41 10.04 173 131709 35742 110421675
Arthropathy 110.32 10.04 108 131774 287414 110170003
Hypokalaemia 109.81 10.04 470 131412 181978 110275439
Gangrene 108.67 10.04 115 131767 16226 110441191
Steroid dependence 108.32 10.04 86 131796 8383 110449034
Drug reaction with eosinophilia and systemic symptoms 108.08 10.04 276 131606 81819 110375598
Stomatitis 107.80 10.04 98 131784 270144 110187273
Facial pain 107.46 10.04 111 131771 15228 110442189
Arterial occlusive disease 104.06 10.04 109 131773 15199 110442218
Hypopnoea 103.46 10.04 95 131787 11285 110446132
Discomfort 103.45 10.04 64 131818 214643 110242774
Lip dry 101.82 10.04 4 131878 100079 110357338
Ejection fraction 99.66 10.04 55 131827 2900 110454517
Hypoaesthesia 99.08 10.04 138 131744 314085 110143332
Lactic acidosis 97.26 10.04 287 131595 92524 110364893
Exposure during pregnancy 97.07 10.04 39 131843 167385 110290032
Blister 94.87 10.04 79 131803 227297 110230120
Obesity 94.17 10.04 12 131870 113339 110344078
Cross sensitivity reaction 92.24 10.04 66 131816 5501 110451916
Pain of skin 91.24 10.04 116 131766 19913 110437504
Weight increased 91.14 10.04 231 131651 419413 110038004
Maternal exposure during pregnancy 90.74 10.04 102 131780 254781 110202636
Parosmia 89.86 10.04 94 131788 13086 110444331
Gingival pain 89.47 10.04 102 131780 15634 110441783
Disturbance in attention 87.45 10.04 214 131668 61781 110395636
Interstitial lung disease 86.97 10.04 363 131519 138971 110318446
Subarachnoid haemorrhage 85.13 10.04 138 131744 29564 110427853
Agranulocytosis 84.80 10.04 211 131671 61549 110395868
Ventricular tachycardia 84.13 10.04 185 131697 49824 110407593
Diplopia 83.34 10.04 166 131716 41728 110415689
Dysphagia 82.83 10.04 383 131499 153217 110304200
Sinus congestion 82.56 10.04 138 131744 30321 110427096
Facet joint syndrome 81.05 10.04 10 131872 96818 110360599
Lymphatic fistula 80.04 10.04 38 131844 1457 110455960
Nightmare 78.52 10.04 155 131727 38708 110418709
Blood cholesterol increased 77.33 10.04 64 131818 184721 110272696
Hypergastrinaemia 77.32 10.04 25 131857 331 110457086
Blindness 77.10 10.04 148 131734 36211 110421206
Femoral hernia incarcerated 76.67 10.04 37 131845 1472 110455945
Rash maculo-papular 76.32 10.04 228 131654 73994 110383423
Toxic skin eruption 75.03 10.04 125 131757 27390 110430027
Eczema 74.26 10.04 222 131660 72071 110385346
Rhinitis 73.30 10.04 111 131771 22434 110434983
Hepatic enzyme increased 72.50 10.04 173 131709 320719 110136698
Eosinophilia 72.37 10.04 191 131691 57745 110399672
Mobility decreased 71.16 10.04 108 131774 237314 110220103
Dysarthria 70.62 10.04 241 131641 83880 110373537
Night sweats 68.71 10.04 37 131845 133946 110323471
Joint range of motion decreased 68.01 10.04 30 131852 121802 110335615
Joint swelling 67.54 10.04 285 131597 442560 110014857
Human rhinovirus test positive 67.45 10.04 32 131850 1225 110456192
Road traffic accident 67.36 10.04 22 131860 107376 110350041
Pancreatic steatosis 67.25 10.04 36 131846 1786 110455631
Occult blood 66.62 10.04 36 131846 1820 110455597
Rheumatoid factor positive 66.57 10.04 37 131845 131603 110325814
Hepatojugular reflux 66.43 10.04 27 131855 708 110456709
Systemic lupus erythematosus 65.87 10.04 127 131755 254211 110203206
Hiatus hernia 65.58 10.04 118 131764 27488 110429929
Presbyacusis 64.91 10.04 41 131841 2778 110454639
Muscle twitching 64.89 10.04 123 131759 29812 110427605
Subacute cutaneous lupus erythematosus 64.49 10.04 51 131831 4943 110452474
Wound infection pseudomonas 62.98 10.04 38 131844 2373 110455044
Contusion 62.65 10.04 114 131768 233247 110224170
Nephrectomy 62.30 10.04 39 131843 2601 110454816
Arthritis 62.24 10.04 377 131505 167209 110290208
Respiratory syncytial virus test positive 62.21 10.04 32 131850 1462 110455955
Skin haemorrhage 61.40 10.04 108 131774 24719 110432698
Alopecia 61.17 10.04 226 131656 364527 110092890
Angina pectoris 60.89 10.04 188 131694 62107 110395310
Type 2 diabetes mellitus 60.82 10.04 73 131809 177159 110280258
Nasopharyngitis 59.39 10.04 255 131627 394106 110063311
Electrocardiogram Q wave abnormal 59.35 10.04 25 131857 719 110456698
Systolic dysfunction 58.98 10.04 46 131836 4369 110453048
Anaemia macrocytic 58.80 10.04 57 131825 7246 110450171
Vasculitis 58.42 10.04 131 131751 35742 110421675
Arterial haemorrhage 58.10 10.04 43 131839 3776 110453641
Hyperkalaemia 57.95 10.04 317 131565 135479 110321938
Lower limb fracture 57.92 10.04 10 131872 75338 110382079
Cataract 57.58 10.04 217 131665 79268 110378149
Sleep disorder due to general medical condition, insomnia type 57.43 10.04 27 131855 105616 110351801
Gait inability 57.34 10.04 47 131835 136329 110321088
Respiratory tract congestion 56.32 10.04 118 131764 30739 110426678
Vertigo 56.30 10.04 229 131653 86641 110370776
Knee arthroplasty 56.13 10.04 6 131876 64942 110392475
Therapy non-responder 55.91 10.04 63 131819 157244 110300173
Pleural thickening 55.63 10.04 40 131842 3359 110454058
Rash papular 55.55 10.04 110 131772 27529 110429888
Ill-defined disorder 54.47 10.04 64 131818 156789 110300628
Autoimmune disorder 54.23 10.04 7 131875 65476 110391941
Alcohol poisoning 53.90 10.04 60 131822 8960 110448457
Treatment failure 53.88 10.04 161 131721 277073 110180344
Nail disorder 53.71 10.04 4 131878 57931 110399486
Sneezing 53.43 10.04 118 131764 31866 110425551
Rhabdomyolysis 53.36 10.04 284 131598 120117 110337300
Accidental overdose 53.07 10.04 159 131723 51675 110405742
Grip strength decreased 52.85 10.04 15 131867 80159 110377258
Lower respiratory tract infection 52.59 10.04 134 131748 242972 110214445
Seroma 52.10 10.04 38 131844 3263 110454154
Live birth 51.74 10.04 10 131872 69474 110387943
Degenerative mitral valve disease 51.48 10.04 18 131864 307 110457110
Blood magnesium increased 51.43 10.04 40 131842 3783 110453634
Prescribed overdose 51.41 10.04 20 131862 87561 110369856
Eructation 51.18 10.04 73 131809 13984 110443433
Muscular weakness 50.92 10.04 486 131396 247982 110209435
Acute generalised exanthematous pustulosis 50.70 10.04 92 131790 21572 110435845
Sinus disorder 50.50 10.04 117 131765 32611 110424806
Eye pruritus 50.39 10.04 117 131765 32658 110424759
Myelosuppression 49.93 10.04 25 131857 94315 110363102
Cardiac murmur 49.48 10.04 98 131784 24530 110432887
Impaired healing 49.39 10.04 100 131782 196617 110260800
Pleural fibrosis 49.30 10.04 41 131841 4267 110453150
Hypercholesterolaemia 48.18 10.04 24 131858 90813 110366604
Completed suicide 47.64 10.04 140 131742 242241 110215176
Febrile bone marrow aplasia 47.16 10.04 79 131803 17386 110440031
Hallucination 46.84 10.04 242 131640 101190 110356227
Hip arthroplasty 46.14 10.04 6 131876 55807 110401610
Transient ischaemic attack 45.78 10.04 174 131708 63808 110393609
Infusion related reaction 45.62 10.04 267 131615 380895 110076522
Urate nephropathy 45.56 10.04 15 131867 211 110457206
Epigastric discomfort 45.54 10.04 55 131827 8960 110448457
Acquired haemophilia 45.45 10.04 32 131850 2599 110454818
Troponin T increased 45.21 10.04 39 131843 4267 110453150
Cardiac failure 45.11 10.04 380 131502 187246 110270171
Injection site pain 45.05 10.04 90 131792 177832 110279585
Wound infection 44.74 10.04 30 131852 96435 110360982
Rhinitis allergic 44.36 10.04 78 131804 17844 110439573
Osteopenia 44.17 10.04 88 131794 22121 110435296
Cerebrovascular accident 44.03 10.04 368 131514 180916 110276501
Sciatica 43.86 10.04 28 131854 92371 110365046
Abdominal pain upper 42.60 10.04 618 131264 348493 110108924
Drug hypersensitivity 42.50 10.04 342 131540 453748 110003669
Lip swelling 42.38 10.04 145 131737 50522 110406895
Infection 42.14 10.04 256 131626 361944 110095473
Ejection fraction abnormal 41.84 10.04 34 131848 3426 110453991
Mitral valve incompetence 41.74 10.04 110 131772 33219 110424198
Liver injury 41.70 10.04 72 131810 150341 110307076
COVID-19 41.48 10.04 461 131421 244599 110212818
Drug abuse 41.36 10.04 94 131788 177317 110280100
Sleep disorder 41.05 10.04 112 131770 198532 110258885
Bone erosion 40.80 10.04 4 131878 46367 110411050
Gastric polyps 40.56 10.04 41 131841 5482 110451935
Dermatitis bullous 40.46 10.04 74 131808 17455 110439962
Wheezing 40.28 10.04 162 131720 255068 110202349
Musculoskeletal pain 40.26 10.04 100 131782 182923 110274494
Viral test positive 40.04 10.04 20 131862 858 110456559
Bursitis 39.98 10.04 58 131824 129860 110327557
Renal failure 39.62 10.04 429 131453 226145 110231272
Peripheral venous disease 39.23 10.04 26 131856 84091 110373326
Liver function test increased 39.14 10.04 29 131853 88519 110368898
Platelet count decreased 38.46 10.04 143 131739 230300 110227117
Carpal tunnel syndrome 38.43 10.04 84 131798 22526 110434891
Inferior vena cava dilatation 38.22 10.04 20 131862 947 110456470
Pneumonia haemophilus 37.82 10.04 29 131853 2686 110454731
Vitamin B12 deficiency 37.76 10.04 53 131829 10002 110447415
Renal injury 37.04 10.04 74 131808 18639 110438778
Carotid arteriosclerosis 36.88 10.04 30 131852 3027 110454390
Tenosynovitis stenosans 36.55 10.04 32 131850 3571 110453846
Tricuspid valve incompetence 36.46 10.04 85 131797 23788 110433629
Laryngitis 36.44 10.04 4 131878 42407 110415010
Anaemia vitamin B12 deficiency 36.41 10.04 21 131861 1206 110456211
Ventricular hypokinesia 36.15 10.04 55 131827 11159 110446258
Faecaloma 35.76 10.04 64 131818 14844 110442573
Diverticulum intestinal 35.71 10.04 56 131826 11663 110445754
Cell death 35.43 10.04 39 131843 5752 110451665
Electrocardiogram QT prolonged 34.82 10.04 236 131646 108724 110348693
Tumour fistulisation 34.78 10.04 11 131871 135 110457282
Post cholecystectomy syndrome 34.76 10.04 18 131864 834 110456583
Ischaemic stroke 34.43 10.04 118 131764 41145 110416272
X-ray abnormal 34.31 10.04 3 131879 38114 110419303
Haemarthrosis 34.26 10.04 43 131839 7286 110450131
Multi-organ disorder 34.24 10.04 30 131852 3351 110454066
Amniotic fluid index increased 34.02 10.04 10 131872 94 110457323
Pulmonary vascular disorder 33.57 10.04 19 131863 1052 110456365
Laboratory test abnormal 33.55 10.04 6 131876 44073 110413344
Blood test abnormal 33.50 10.04 92 131790 28462 110428955
Electric shock 33.37 10.04 23 131859 1805 110455612
Sleep apnoea syndrome 33.17 10.04 115 131767 40332 110417085
Injection site erythema 33.15 10.04 38 131844 94138 110363279
Deformity 33.00 10.04 50 131832 10110 110447307
Wound dehiscence 32.97 10.04 44 131838 7918 110449499
Condition aggravated 32.93 10.04 648 131234 734188 109723229
Dermatitis exfoliative generalised 32.84 10.04 52 131830 10920 110446497
Anaphylactic reaction 32.69 10.04 241 131641 114059 110343358
Coeliac disease 32.61 10.04 6 131876 43181 110414236
Cognitive disorder 32.56 10.04 197 131685 87314 110370103
Helicobacter gastritis 32.25 10.04 26 131856 2590 110454827
Taste disorder 32.16 10.04 19 131863 65368 110392049
Blood pressure systolic abnormal 32.13 10.04 83 131799 24767 110432650
Oedema 32.05 10.04 135 131747 209841 110247576
Pulmonary valve disease 31.80 10.04 13 131869 346 110457071
Tongue biting 31.63 10.04 27 131855 2912 110454505
No adverse event 31.59 10.04 25 131857 73814 110383603
Vascular purpura 31.43 10.04 30 131852 3741 110453676
Mesenteric panniculitis 31.36 10.04 15 131867 585 110456832
Administration site inflammation 31.17 10.04 9 131873 79 110457338
Neurosis 31.12 10.04 15 131867 595 110456822
Aortic valve stenosis 30.87 10.04 38 131844 6312 110451105
Thrombocytopenia 30.87 10.04 586 131296 348299 110109118
Osteoarthritis 30.69 10.04 113 131769 182510 110274907
White blood cell count decreased 30.56 10.04 155 131727 229235 110228182
Off label use 30.50 10.04 1471 130411 1498714 108958703
Oesophageal ulcer haemorrhage 30.14 10.04 17 131865 935 110456482
Anuria 30.14 10.04 80 131802 24261 110433156
Physical examination abnormal 29.85 10.04 14 131868 522 110456895
Product quality issue 29.66 10.04 29 131853 77270 110380147
Spontaneous haematoma 29.65 10.04 22 131860 1939 110455478
Cutaneous lupus erythematosus 29.55 10.04 28 131854 3460 110453957
Hepatic cyst 29.19 10.04 41 131841 7742 110449675
Ventricular arrhythmia 29.09 10.04 47 131835 10040 110447377
Herpes zoster 29.02 10.04 53 131829 108326 110349091
Hyperhidrosis 28.85 10.04 346 131536 186952 110270465
Finger deformity 28.74 10.04 3 131879 33089 110424328
Ear infection 28.44 10.04 20 131862 62712 110394705
Dry mouth 28.43 10.04 132 131750 199816 110257601
Shock haemorrhagic 28.29 10.04 84 131798 27163 110430254
Injection site pruritus 28.01 10.04 13 131869 51245 110406172
Deafness neurosensory 27.98 10.04 45 131837 9574 110447843
Injection site swelling 27.62 10.04 20 131862 61770 110395647
Type I hypersensitivity 27.51 10.04 36 131846 6357 110451060
Eosinophilic colitis 27.43 10.04 14 131868 629 110456788
Tachyarrhythmia 27.32 10.04 41 131841 8220 110449197
Nicotine dependence 27.30 10.04 18 131864 1313 110456104
Swelling face 27.17 10.04 196 131686 92125 110365292
Jaundice 27.11 10.04 141 131741 59095 110398322
Muscle haemorrhage 26.98 10.04 37 131845 6832 110450585
Musculoskeletal stiffness 26.97 10.04 209 131673 279613 110177804
Impaired quality of life 26.96 10.04 88 131794 29929 110427488
High grade B-cell lymphoma Burkitt-like lymphoma recurrent 26.87 10.04 8 131874 79 110457338
Surgery 26.70 10.04 8 131874 41275 110416142
Disease progression 26.56 10.04 176 131706 243858 110213559
Rheumatoid nodule 26.46 10.04 68 131814 20228 110437189
Pericarditis 26.46 10.04 153 131729 218961 110238456
Device expulsion 26.32 10.04 3 131879 30888 110426529
Erythema dyschromicum perstans 26.26 10.04 8 131874 86 110457331
Hepatitis cholestatic 26.23 10.04 62 131820 17504 110439913
IIIrd nerve paresis 26.19 10.04 10 131872 221 110457196
Back injury 25.94 10.04 12 131870 47387 110410030
Product use issue 25.91 10.04 242 131640 311453 110145964
Pericardial disease 25.89 10.04 14 131868 709 110456708
Seizure 25.88 10.04 156 131726 221029 110236388
Allergic keratitis 25.86 10.04 6 131876 19 110457398
Incorrect route of product administration 25.80 10.04 23 131859 64038 110393379
Onychomycosis 25.78 10.04 7 131875 38524 110418893
Fatigue 25.72 10.04 1187 130695 1214771 109242646
Disability 25.59 10.04 3 131879 30220 110427197
Foetal macrosomia 25.53 10.04 8 131874 95 110457322
Gastritis 25.40 10.04 129 131753 53570 110403847
Colitis microscopic 25.36 10.04 52 131830 13342 110444075
Muscle spasms 25.31 10.04 211 131671 277946 110179471
Rectosigmoid cancer 25.23 10.04 11 131871 345 110457072
Therapy interrupted 25.19 10.04 14 131868 49808 110407609
Cardiac aneurysm 25.10 10.04 19 131863 1726 110455691
Bronchiectasis 25.08 10.04 98 131784 36395 110421022
Fibromyalgia 24.79 10.04 112 131770 170797 110286620
Urticaria 24.64 10.04 252 131630 318605 110138812
Blood immunoglobulin A increased 24.63 10.04 18 131864 1550 110455867
Aspartate aminotransferase 24.61 10.04 15 131867 954 110456463
Paraesthesia 24.60 10.04 211 131671 276310 110181107
Chest discomfort 24.55 10.04 316 131566 173532 110283885
Fluid retention 24.47 10.04 47 131835 94260 110363157
Vitamin B12 increased 24.44 10.04 20 131862 2035 110455382
Drug resistance 24.23 10.04 19 131863 56355 110401062
Fall 24.05 10.04 913 130969 602569 109854848
Nephropathy 24.00 10.04 51 131831 13416 110444001
Tubulointerstitial nephritis and uveitis syndrome 23.84 10.04 11 131871 395 110457022
Urticaria papular 23.76 10.04 10 131872 287 110457130
Purple glove syndrome 23.76 10.04 10 131872 287 110457130
Intervertebral discitis 23.56 10.04 35 131847 6955 110450462
Gait disturbance 23.56 10.04 215 131667 277993 110179424
Blood pressure diastolic abnormal 23.47 10.04 76 131806 25739 110431678
Persistent depressive disorder 23.30 10.04 17 131865 1460 110455957
Glomerular filtration rate increased 23.28 10.04 19 131863 1926 110455491
Acute hepatitis B 23.19 10.04 12 131870 555 110456862
Ventricular enlargement 23.12 10.04 13 131869 711 110456706
Circumoral oedema 23.09 10.04 11 131871 425 110456992
Gallbladder polyp 23.04 10.04 16 131866 1271 110456146
Pulmonary hypertension 22.94 10.04 128 131754 55092 110402325
Granulomatous rosacea 22.85 10.04 9 131873 217 110457200
Mouth haemorrhage 22.80 10.04 50 131832 13438 110443979
Hypoparathyroidism 22.77 10.04 17 131865 1513 110455904
Aortic arteriosclerosis 22.55 10.04 44 131838 10894 110446523
Headache 22.45 10.04 1276 130606 881101 109576316
Vulvovaginal burning sensation 22.25 10.04 19 131863 2050 110455367
Hepatic steatosis 22.19 10.04 116 131766 48715 110408702
End stage renal disease 22.10 10.04 66 131816 21407 110436010
Injection site haemorrhage 22.10 10.04 6 131876 33022 110424395
Dizziness 22.05 10.04 649 131233 697544 109759873
Pharyngeal necrosis 21.98 10.04 7 131875 88 110457329
Occupational dermatitis 21.93 10.04 8 131874 155 110457262
Osteosclerosis 21.92 10.04 27 131855 4488 110452929
Synovial fluid analysis 21.73 10.04 21 131861 2660 110454757
Urinary retention 21.71 10.04 150 131732 69533 110387884
Papillary renal cell carcinoma 21.68 10.04 10 131872 359 110457058
Bone cyst 21.58 10.04 24 131858 3579 110453838
Inflammatory marker increased 21.53 10.04 51 131831 14418 110442999
Allergy to chemicals 21.40 10.04 23 131859 3302 110454115
Lip oedema 21.36 10.04 35 131847 7565 110449852
Cardiac arrest 21.36 10.04 142 131740 196611 110260806
Aortic valve incompetence 21.22 10.04 43 131839 10938 110446479
Clinically isolated syndrome 21.16 10.04 6 131876 49 110457368
Injection site bruising 21.13 10.04 18 131864 51245 110406172
Immunodeficiency 20.99 10.04 10 131872 38828 110418589
Contraindicated product administered 20.96 10.04 192 131690 248075 110209342
Granulocyte count increased 20.90 10.04 18 131864 1965 110455452
Pain 20.81 10.04 929 130953 954026 109503391
Hypoparathyroidism secondary 20.71 10.04 9 131873 280 110457137
Sudden death 20.56 10.04 70 131812 24325 110433092
Groin pain 20.43 10.04 52 131830 15376 110442041
Skin ulcer 20.42 10.04 138 131744 63507 110393910
Infective exacerbation of chronic obstructive airways disease 20.41 10.04 22 131860 3168 110454249
Ear pain 20.38 10.04 20 131862 53206 110404211
Left-to-right cardiac shunt 20.30 10.04 8 131874 193 110457224
Multiple sclerosis relapse 20.27 10.04 18 131864 50222 110407195
Malnutrition 20.19 10.04 75 131807 27204 110430213
Influenza like illness 20.15 10.04 177 131705 88235 110369182
Helicobacter test positive 20.06 10.04 15 131867 1338 110456079
Fixed eruption 20.05 10.04 25 131857 4207 110453210
Walking aid user 20.01 10.04 3 131879 25072 110432345
Hypothyroidism 19.88 10.04 152 131730 72747 110384670
Escherichia infection 19.78 10.04 68 131814 23748 110433669
Dry eye 19.74 10.04 124 131758 55669 110401748
Vulvovaginal pruritus 19.63 10.04 22 131860 3309 110454108
Respiratory distress 19.56 10.04 145 131737 68729 110388688
COVID-19 treatment 19.52 10.04 10 131872 453 110456964
Emotional distress 19.42 10.04 15 131867 44832 110412585
Miosis 19.34 10.04 64 131818 21919 110435498
Blood parathyroid hormone decreased 19.33 10.04 46 131836 13043 110444374
Tongue injury 19.24 10.04 11 131871 621 110456796
Angiopathy 19.08 10.04 36 131846 8694 110448723
Cough 19.00 10.04 701 131181 460940 109996477
Pericardial effusion 18.92 10.04 125 131757 57092 110400325
Synovial cyst 18.90 10.04 42 131840 11388 110446029
Cystitis 18.74 10.04 139 131743 65897 110391520
Type III immune complex mediated reaction 18.64 10.04 13 131869 1040 110456377
Blood pressure systolic decreased 18.53 10.04 46 131836 13395 110444022
Idiosyncratic drug reaction 18.37 10.04 15 131867 1521 110455896
Dysphonia 18.35 10.04 154 131728 75775 110381642
Duodenal polyp 18.34 10.04 10 131872 515 110456902
Epiglottic erythema 18.32 10.04 6 131876 83 110457334
Haematuria 18.31 10.04 165 131717 82840 110374577
Rectal haemorrhage 18.28 10.04 221 131661 119612 110337805
Genital infection female 18.25 10.04 6 131876 84 110457333
Vitreous detachment 18.15 10.04 19 131863 2646 110454771
Gastroenteritis eosinophilic 18.11 10.04 9 131873 382 110457035
Therapeutic product effect decreased 18.09 10.04 195 131687 244121 110213296
Quadriparesis 17.96 10.04 25 131857 4682 110452735
Renal tubular disorder 17.96 10.04 32 131850 7397 110450020
Occupational exposure to air contaminants 17.92 10.04 7 131875 165 110457252
Photosensitivity reaction 17.82 10.04 69 131813 25520 110431897
Left ventricular dysfunction 17.73 10.04 65 131817 23428 110433989
Haematemesis 17.69 10.04 126 131756 58982 110398435
Rheumatoid factor increased 17.32 10.04 18 131864 2487 110454930
Anxiety 17.23 10.04 536 131346 344542 110112875
Adverse event 17.19 10.04 69 131813 108740 110348677
Infusion site scar 17.18 10.04 9 131873 427 110456990
Haematochezia 17.17 10.04 212 131670 115312 110342105
Tachycardia 17.15 10.04 372 131510 226273 110231144
Underdose 17.09 10.04 31 131851 63523 110393894
Face oedema 16.96 10.04 82 131800 33387 110424030
Dysgeusia 16.94 10.04 142 131740 69843 110387574
Diarrhoea 16.82 10.04 1577 130305 1137928 109319489
Gamma-glutamyltransferase increased 16.81 10.04 128 131754 61181 110396236
Campylobacter colitis 16.76 10.04 6 131876 110 110457307
Primary adrenal insufficiency 16.73 10.04 10 131872 614 110456803
Sinusitis 16.68 10.04 251 131631 296437 110160980
Normal newborn 16.62 10.04 3 131879 21893 110435524
Pneumobilia 16.49 10.04 8 131874 322 110457095
Tumour perforation 16.42 10.04 10 131872 635 110456782
Adenocarcinoma gastric 16.31 10.04 16 131866 2063 110455354
Full blood count decreased 16.25 10.04 9 131873 32090 110425327
Hepatitis B DNA increased 16.18 10.04 11 131871 844 110456573
Gastric adenoma 16.13 10.04 4 131878 18 110457399
Depression 16.00 10.04 274 131608 317061 110140356
Ulcer 15.99 10.04 97 131785 43019 110414398
Treatment noncompliance 15.95 10.04 40 131842 72950 110384467
Therapy cessation 15.89 10.04 18 131864 44839 110412578
Food interaction 15.85 10.04 16 131866 2136 110455281
Brief psychotic disorder with marked stressors 15.83 10.04 8 131874 352 110457065
Postoperative wound infection 15.82 10.04 48 131834 15705 110441712
Normocytic anaemia 15.82 10.04 28 131854 6439 110450978
Aggression 15.81 10.04 29 131853 59181 110398236
Haemorrhagic stroke 15.75 10.04 44 131838 13745 110443672
Accidental exposure to product 15.70 10.04 22 131860 49986 110407431
Therapeutic product effect incomplete 15.63 10.04 181 131701 223624 110233793
Cerebral haematoma 15.49 10.04 35 131847 9597 110447820
Hypocapnia 15.43 10.04 11 131871 911 110456506
Rash 15.43 10.04 811 131071 820153 109637264
Hemianopia 15.31 10.04 18 131864 2850 110454567
Ulcer haemorrhage 15.29 10.04 4 131878 22567 110434850
Mixed liver injury 15.26 10.04 40 131842 12039 110445378
Hyperemesis gravidarum 15.26 10.04 9 131873 539 110456878
Constipation 15.24 10.04 318 131564 357468 110099949
Creatinine renal clearance abnormal 15.23 10.04 10 131872 724 110456693
Rectal cancer metastatic 15.21 10.04 9 131873 542 110456875
Phaeochromocytoma malignant 15.21 10.04 5 131877 70 110457347
Placental calcification 15.18 10.04 4 131878 24 110457393
Respiratory arrest 15.17 10.04 29 131853 58270 110399147
Coma acidotic 15.14 10.04 6 131876 147 110457270
Cardiac discomfort 15.13 10.04 13 131869 1415 110456002
Cerebellar syndrome 15.05 10.04 27 131855 6275 110451142
Loss of personal independence in daily activities 15.02 10.04 257 131625 149763 110307654
Bladder cancer 14.94 10.04 3 131879 20289 110437128
Skin exfoliation 14.86 10.04 165 131717 87486 110369931
Toxicity to various agents 14.83 10.04 448 131434 480107 109977310
Dermatitis atopic 14.71 10.04 6 131876 25535 110431882
Complication associated with device 14.71 10.04 3 131879 20070 110437347
Device related bacteraemia 14.69 10.04 12 131870 1218 110456199
Hypoosmolar state 14.69 10.04 8 131874 411 110457006
CSF protein increased 14.64 10.04 13 131869 1478 110455939
Diastolic dysfunction 14.59 10.04 40 131842 12364 110445053
Amaurosis fugax 14.45 10.04 16 131866 2374 110455043
Enterochromaffin cell hyperplasia 14.42 10.04 5 131877 83 110457334
Distal intestinal obstruction syndrome 14.39 10.04 11 131871 1014 110456403
Acute on chronic liver failure 14.39 10.04 8 131874 428 110456989
Neutrophil count decreased 14.30 10.04 85 131797 120856 110336561
Simple partial seizures 14.29 10.04 11 131871 1025 110456392
Hypertensive nephropathy 14.27 10.04 11 131871 1027 110456390
Dyspnoea at rest 14.17 10.04 31 131851 8315 110449102
Salpingo-oophorectomy unilateral 14.11 10.04 10 131872 821 110456596
Pain in extremity 14.09 10.04 458 131424 486660 109970757
Change in seizure presentation 14.08 10.04 10 131872 824 110456593
Microcytic anaemia 14.04 10.04 26 131856 6192 110451225
Tri-iodothyronine free decreased 14.00 10.04 8 131874 451 110456966
Schizophreniform disorder 13.98 10.04 6 131876 181 110457236
Scleritis 13.95 10.04 24 131858 5396 110452021
Myoglobinaemia 13.95 10.04 6 131876 182 110457235
Cutaneous vasculitis 13.94 10.04 40 131842 12689 110444728
Infusion site thrombosis 13.87 10.04 7 131875 307 110457110
Meningitis aseptic 13.84 10.04 34 131848 9836 110447581
Crepitations 13.81 10.04 36 131846 10799 110446618
Neck pain 13.80 10.04 88 131794 123042 110334375
Diabetes mellitus inadequate control 13.71 10.04 71 131811 29704 110427713
Pancreatitis necrotising 13.69 10.04 24 131858 5477 110451940
Back disorder 13.63 10.04 4 131878 20918 110436499
Tetany 13.54 10.04 19 131863 3585 110453832
Blood pressure diastolic decreased 13.48 10.04 81 131801 35804 110421613
Fractured skull depressed 13.39 10.04 4 131878 40 110457377
Septic shock 13.37 10.04 263 131619 157265 110300152
Antinuclear antibody positive 13.30 10.04 32 131850 9136 110448281
Genotype drug resistance test positive 13.29 10.04 12 131870 1394 110456023
Chronic obstructive pulmonary disease 13.29 10.04 76 131806 109082 110348335
Uveal melanoma 13.21 10.04 4 131878 42 110457375
Skin lesion 13.16 10.04 106 131776 51525 110405892
Axonal neuropathy 13.13 10.04 15 131867 2303 110455114
Confusional state 13.12 10.04 684 131198 467996 109989421
Prescription form tampering 13.06 10.04 8 131874 513 110456904
Synovial disorder 13.04 10.04 17 131865 2990 110454427
Nephrosclerosis 13.04 10.04 14 131868 2007 110455410
Left ventricular hypertrophy 12.97 10.04 40 131842 13204 110444213
Renal infarct 12.91 10.04 18 131864 3377 110454040
Peripheral swelling 12.87 10.04 375 131507 403659 110053758
Hyponatraemic seizure 12.79 10.04 9 131873 730 110456687
High frequency ablation 12.79 10.04 7 131875 363 110457054
Insulin autoimmune syndrome 12.76 10.04 9 131873 733 110456684
Injection site rash 12.70 10.04 6 131876 23413 110434004
Vulvovaginal inflammation 12.69 10.04 9 131873 740 110456677
Cardiac disorder 12.66 10.04 143 131739 76137 110381280
Malignant neoplasm progression 12.65 10.04 140 131742 174427 110282990
Rhinorrhoea 12.60 10.04 182 131700 102484 110354933
Dehiscence 12.59 10.04 9 131873 749 110456668
Burning sensation 12.53 10.04 132 131750 69080 110388337
Oral mucosa erosion 12.47 10.04 15 131867 2433 110454984
Vaginal discharge 12.47 10.04 3 131879 17905 110439512
Migraine 12.43 10.04 280 131602 171372 110286045
Illness 12.43 10.04 53 131829 82118 110375299
Neuropsychiatric lupus 12.40 10.04 6 131876 240 110457177
Bradypnoea 12.35 10.04 30 131852 8619 110448798
Gastrointestinal motility disorder 12.33 10.04 27 131855 7249 110450168
Benign soft tissue neoplasm 12.27 10.04 5 131877 132 110457285
Tenosynovitis 12.24 10.04 45 131837 16238 110441179
Red blood cell sedimentation rate abnormal 12.23 10.04 7 131875 24502 110432915
Wrong technique in product usage process 12.21 10.04 58 131824 87290 110370127
Thymus disorder 12.20 10.04 8 131874 578 110456839
COVID-19 pneumonia 12.19 10.04 81 131801 37062 110420355
Neoplasm progression 12.19 10.04 38 131844 64557 110392860
Duodenitis 12.18 10.04 31 131851 9165 110448252
Tongue oedema 12.18 10.04 29 131853 8227 110449190
Ventricular fibrillation 12.17 10.04 19 131863 41294 110416123
Pericardial haemorrhage 12.01 10.04 22 131860 5195 110452222
Gastrointestinal haemorrhage 11.99 10.04 270 131612 165248 110292169
Injection site warmth 11.96 10.04 3 131879 17402 110440015
Cyst 11.91 10.04 45 131837 16451 110440966
Bacterial infection 11.89 10.04 23 131859 46013 110411404
Neuroleptic malignant syndrome 11.71 10.04 14 131868 34045 110423372
Renal tubular atrophy 11.68 10.04 14 131868 2262 110455155
Xerosis 11.67 10.04 12 131870 1637 110455780
Pneumonia 11.64 10.04 894 130988 875820 109581597
Drug clearance decreased 11.61 10.04 19 131863 4103 110453314
Epiglottic oedema 11.57 10.04 7 131875 439 110456978
Photophobia 11.55 10.04 61 131821 25710 110431707
Lung neoplasm malignant 11.54 10.04 14 131868 33828 110423589
Device difficult to use 11.53 10.04 4 131878 18801 110438616
Gastritis erosive 11.52 10.04 36 131846 11964 110445453
Streptococcal endocarditis 11.51 10.04 6 131876 282 110457135
Hypercalcaemia 11.47 10.04 95 131787 46562 110410855
Capillary permeability increased 11.45 10.04 4 131878 68 110457349
Scar 11.42 10.04 3 131879 16878 110440539
Electrocardiogram repolarisation abnormality 11.40 10.04 14 131868 2321 110455096
Thrombocytopenic purpura 11.38 10.04 16 131866 3023 110454394
Lichenoid keratosis 11.38 10.04 24 131858 6278 110451139
Mitral valve disease 11.33 10.04 17 131865 3408 110454009
Intestinal diaphragm disease 11.29 10.04 7 131875 459 110456958
Sputum discoloured 11.29 10.04 10 131872 27935 110429482
Drug dependence 11.25 10.04 27 131855 49993 110407424
Conversion disorder 11.23 10.04 14 131868 2356 110455061
Aplastic anaemia 11.22 10.04 58 131824 24250 110433167
Craniocerebral injury 11.19 10.04 23 131859 5911 110451506
Carnitine deficiency 11.16 10.04 6 131876 300 110457117
Arterial spasm 11.15 10.04 5 131877 168 110457249
Spinal disorder 11.09 10.04 35 131847 11693 110445724
Erythema annulare 11.09 10.04 6 131876 304 110457113
Intervertebral disc protrusion 11.08 10.04 10 131872 27688 110429729
Carotid artery stenosis 11.02 10.04 30 131852 9233 110448184
Food allergy 10.99 10.04 5 131877 19943 110437474
Rhinovirus infection 10.98 10.04 35 131847 11754 110445663
Joint noise 10.98 10.04 21 131861 5122 110452295
Throat clearing 10.91 10.04 19 131863 4314 110453103
Diabetic ketosis 10.90 10.04 9 131873 927 110456490
Calcium metabolism disorder 10.90 10.04 4 131878 79 110457338
Hyperlipasaemia 10.84 10.04 11 131871 1478 110455939
Cellulitis 10.83 10.04 97 131785 125919 110331498
Enterocolitis 10.76 10.04 48 131834 18901 110438516
Immune reconstitution inflammatory syndrome 10.76 10.04 3 131879 16223 110441194
Coma 10.76 10.04 199 131683 117670 110339747
Culture urine positive 10.76 10.04 20 131862 4776 110452641
Asthmatic crisis 10.71 10.04 13 131869 2129 110455288
Odynophagia 10.63 10.04 39 131843 14062 110443355
Vulvovaginal erythema 10.62 10.04 7 131875 510 110456907
Incorrect product dosage form administered 10.62 10.04 6 131876 331 110457086
On and off phenomenon 10.62 10.04 19 131863 4405 110453012
Mast cell activation syndrome 10.60 10.04 11 131871 1517 110455900
Gout 10.60 10.04 17 131865 36549 110420868
Acute coronary syndrome 10.56 10.04 55 131827 23057 110434360
Cholecystitis acute 10.54 10.04 42 131840 15740 110441677
Basal cell carcinoma 10.51 10.04 91 131791 45179 110412238
Device malfunction 10.50 10.04 9 131873 25549 110431868
Long QT syndrome 10.49 10.04 25 131857 7093 110450324
Urticarial vasculitis 10.49 10.04 9 131873 977 110456440
Hypoventilation 10.45 10.04 27 131855 8054 110449363
Paraesthesia oral 10.39 10.04 15 131867 33656 110423761
Mental status changes 10.38 10.04 51 131831 76071 110381346
Ovarian cystectomy 10.37 10.04 4 131878 91 110457326
Mesenteric artery stenosis 10.32 10.04 3 131879 27 110457390
Psychotic disorder 10.31 10.04 29 131853 50908 110406509
Drug delivery device placement 10.27 10.04 5 131877 203 110457214
Dactylitis 10.25 10.04 18 131864 4115 110453302
Stenosis 10.19 10.04 16 131866 3335 110454082
Ocular myasthenia 10.16 10.04 8 131874 770 110456647
Oesophagitis ulcerative 10.15 10.04 11 131871 1594 110455823
Heat stroke 10.09 10.04 12 131870 1923 110455494
Deep vein thrombosis 10.07 10.04 228 131654 139659 110317758
Granuloma skin 10.06 10.04 33 131849 11250 110446167

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02AD02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
ANTACIDS
Combinations and complexes of aluminium, calcium and magnesium compounds
ATC A02AF01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
ANTACIDS
Antacids with antiflatulents
MeSH PA D000863 Antacids
MeSH PA D005765 Gastrointestinal Agents

Related Drugs by ATC class:

A02AD Combinations and complexes of aluminium, calcium and magnesium compounds 2 drugs
almagatealmasilate

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D04832 KEGG_DRUG
4019589 VUID
N0000147685 NUI
4019589 VANDF
CHEBI:755940 CHEBI
CHEMBL3833350 ChEMBL_ID
C016545 MESH_SUPPLEMENTAL_RECORD_UI
1344-82-7 SECONDARY_CAS_RN
DB08938 DRUGBANK_ID
1872036 RXNORM
5004 MMSL
5823 MMSL
7693 MMSL
d00984 MMSL
001127 NDDF
387240004 SNOMEDCT_US
43343000 SNOMEDCT_US
C0065512 UMLSCUI
CHEMBL3833408 ChEMBL_ID
4416 INN_ID
122706784 PUBCHEM_CID
6V88E24N5T UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Zantanol Tab. HUMAN OTC DRUG LABEL 2 58354-101 TABLET 50 mg ORAL OTC monograph final 8 sections