DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
topiroxostat 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
xanthine oxydase and xanthine dehydrogenase inhibitor
4888
577778-58-6
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
SK-0910
topiroxostat
topiloric
uriadec
FYX-051
xanthine oxidoreductase inhibitor
Molecular weight: 248.25
Formula: C13H8N6
CLOGP: 0.92
LIPINSKI: 0
HAC: 6
HDO: 1
TPSA: 91.14
ALOGS: -3.50
ROTB: 2
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
June 28, 2013
PMDA
Senwa Kegaku Kenkyushp
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
MeSH PA
D004791
Enzyme Inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Hyperuricemia
indication
35885006
DOID:1920
Gout
indication
90560007
DOID:13189
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.7
acidic
pKa2
4.07
Basic
pKa3
2.94
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Xanthine dehydrogenase/oxidase
Enzyme
P47989
XDH_HUMAN
INHIBITOR
IC50
8.28
SCIENTIFIC LITERATURE
SCIENTIFIC LITERATURE
ATP-binding cassette sub-family G member 2
Transporter
Q9UNQ0
ABCG2_HUMAN
IC50
6.75
CHEMBL
Xanthine dehydrogenase/oxidase
Enzyme
XDH_BOVIN
IC50
8.32
CHEMBL
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External reference:
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ID
Source
0J877412JV
UNII
10592
IUPHAR_LIGAND_ID
5288320
PUBCHEM_CID
9220
INN_ID
C4049065
UMLSCUI
C504882
MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL1078685
ChEMBL_ID
D09786
KEGG_DRUG
DB01685
DRUGBANK_ID
FYX
PDB_CHEM_ID
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Pharmaceutical products:
None
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topiroxostat