topiroxostat 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
xanthine oxydase and xanthine dehydrogenase inhibitor 4888 577778-58-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • SK-0910
  • topiroxostat
  • topiloric
  • uriadec
  • FYX-051
xanthine oxidoreductase inhibitor
  • Molecular weight: 248.25
  • Formula: C13H8N6
  • CLOGP: 0.92
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 91.14
  • ALOGS: -3.50
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 28, 2013 PMDA Senwa Kegaku Kenkyushp

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D004791 Enzyme Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hyperuricemia indication 35885006 DOID:1920
Gout indication 90560007 DOID:13189




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.7 acidic
pKa2 4.07 Basic
pKa3 2.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Xanthine dehydrogenase/oxidase Enzyme INHIBITOR IC50 8.28 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Xanthine dehydrogenase/oxidase Enzyme IC50 8.32 CHEMBL

External reference:

IDSource
0J877412JV UNII
D09786 KEGG_DRUG
C4049065 UMLSCUI
FYX PDB_CHEM_ID
CHEMBL1078685 ChEMBL_ID
5288320 PUBCHEM_CID
DB01685 DRUGBANK_ID
9220 INN_ID
C504882 MESH_SUPPLEMENTAL_RECORD_UI
10592 IUPHAR_LIGAND_ID

Pharmaceutical products:

None