topiroxostat Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
xanthine oxydase and xanthine dehydrogenase inhibitor 4888 577778-58-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • SK-0910
  • topiroxostat
  • topiloric
  • uriadec
  • FYX-051
xanthine oxidoreductase inhibitor
  • Molecular weight: 248.25
  • Formula: C13H8N6
  • CLOGP: 0.92
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 91.14
  • ALOGS: -3.50
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 28, 2013 PMDA Senwa Kegaku Kenkyushp

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D004791 Enzyme Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hyperuricemia indication 35885006 DOID:1920
Gout indication 90560007 DOID:13189

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.7 acidic
pKa2 4.07 Basic
pKa3 2.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Xanthine dehydrogenase/oxidase Enzyme INHIBITOR IC50 8.28 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D09786 KEGG_DRUG
C1612795 UMLSCUI
FYX PDB_CHEM_ID
CHEMBL1078685 ChEMBL_ID
C504882 MESH_SUPPLEMENTAL_RECORD_UI
9220 INN_ID
DB01685 DRUGBANK_ID
0J877412JV UNII
5288320 PUBCHEM_CID
10592 IUPHAR_LIGAND_ID

Pharmaceutical products:

None