cetilistat Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
gastrointestinal lipase inhibitors 4886 282526-98-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cetilistat
  • ATL-962
  • oblean
lipase inhibitor in randomized, placebo-controlled study of weight reduction in obese patients (3/2007)
  • Molecular weight: 401.59
  • Formula: C25H39NO3
  • CLOGP: 9.52
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 47.89
  • ALOGS: -7.51
  • ROTB: 16

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 20, 2013 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D019440 Anti-Obesity Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D057847 Lipid Regulating Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Obesity indication 414916001 DOID:9970

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Pancreatic triacylglycerol lipase Enzyme INHIBITOR IC50 8.23 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D09208 KEGG_DRUG
C1957371 UMLSCUI
CHEBI:134721 CHEBI
CHEMBL2103825 ChEMBL_ID
DB06586 DRUGBANK_ID
9952916 PUBCHEM_CID
C520092 MESH_SUPPLEMENTAL_RECORD_UI
11433 IUPHAR_LIGAND_ID
8461 INN_ID
LC5G1JUA39 UNII

Pharmaceutical products:

None