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carazolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| beta-adrenoreceptor antagonists | 487 | 57775-29-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 8 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1 | 53 | |||
| kinase-selectivity-class | AXL,BRAF,CAMK2D,CDK4,DYRK1B,MAP2K6,STK33,TTK | 8 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 2.213 | Moderate | 0.70 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 1 | Moderate | 0.70 | |
| rat-kpuu-brain | Rat brain Kpuu | 0.115 | % | Moderate | 0.70 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000319 | Adrenergic beta-Antagonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018674 | Adrenergic Antagonists |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.13 | acidic |
| pKa2 | 9.19 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor | GPCR | ANTAGONIST | Kd | 10.20 | IUPHAR | ||||
| Beta-2 adrenergic receptor | GPCR | Ki | 9.94 | CHEMBL | |||||
| Beta-3 adrenergic receptor | GPCR | AGONIST | Ki | 8.70 | IUPHAR | ||||
| Dynamin-1 | Structural | IC50 | 4.10 | CHEMBL | |||||
| Beta-3 adrenergic receptor | GPCR | AGONIST | Ki | 7.70 | IUPHAR | ||||
| Beta-3 adrenergic receptor | GPCR | AGONIST | Ki | 7.70 | IUPHAR | ||||
| Beta-1 adrenergic receptor | GPCR | Ki | 10.05 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07608 | KEGG_DRUG |
| 20192 | RXNORM |
| C0054636 | UMLSCUI |
| CHEBI:135261 | CHEBI |
| CHEMBL324665 | ChEMBL_ID |
| C014382 | MESH_SUPPLEMENTAL_RECORD_UI |
| 71739 | PUBCHEM_CID |
| 569 | IUPHAR_LIGAND_ID |
| 4036 | INN_ID |
| 29PW75S82A | UNII |
| 006896 | NDDF |
| 29PW75S82A | INXIGHT DRUGS |
Pharmaceutical products:
None