carazolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 487 57775-29-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carazolol
  • DL-Carazolol
  • racemic carazolol
  • Molecular weight: 298.39
  • Formula: C18H22N2O2
  • CLOGP: 3.06
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 57.28
  • ALOGS: -3.98
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.13 acidic
pKa2 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR Ki 9.94 CHEMBL
Beta-3 adrenergic receptor GPCR AGONIST Ki 8.70 IUPHAR
Beta-3 adrenergic receptor GPCR AGONIST Ki 7.70 IUPHAR
Beta-1 adrenergic receptor GPCR Ki 10.05 CHEMBL
Beta-3 adrenergic receptor GPCR AGONIST Ki 7.70 IUPHAR

External reference:

IDSource
D07608 KEGG_DRUG
20192 RXNORM
C0054636 UMLSCUI
CHEBI:135261 CHEBI
CHEMBL324665 ChEMBL_ID
C014382 MESH_SUPPLEMENTAL_RECORD_UI
71739 PUBCHEM_CID
569 IUPHAR_LIGAND_ID
4036 INN_ID
29PW75S82A UNII
006896 NDDF

Pharmaceutical products:

None