carazolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
beta-adrenoreceptor antagonists	487	57775-29-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

carazolol
DL-Carazolol
racemic carazolol

Molecular weight: 298.39
Formula: C18H22N2O2
CLOGP: 3.06
LIPINSKI: 0
HAC: 4
HDO: 3
TPSA: 57.28
ALOGS: -3.98
ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D018674	Adrenergic Antagonists
MeSH PA	D000319	Adrenergic beta-Antagonists
MeSH PA	D018377	Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.13	acidic
pKa2	9.19	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Ki	9.94		CHEMBL
Beta-3 adrenergic receptor	GPCR	P13945	ADRB3_HUMAN	AGONIST	Ki	8.70		IUPHAR
Beta-3 adrenergic receptor	GPCR		ADRB3_MOUSE	AGONIST	Ki	7.70		IUPHAR
Beta-3 adrenergic receptor	GPCR		ADRB3_RAT	AGONIST	Ki	7.70		IUPHAR
Beta-1 adrenergic receptor	GPCR		ADRB1_MOUSE		Ki	10.05		CHEMBL

External reference:

ID	Source
D07608	KEGG_DRUG
20192	RXNORM
C0054636	UMLSCUI
CHEBI:135261	CHEBI
CHEMBL324665	ChEMBL_ID
C014382	MESH_SUPPLEMENTAL_RECORD_UI
71739	PUBCHEM_CID
569	IUPHAR_LIGAND_ID
4036	INN_ID
29PW75S82A	UNII
006896	NDDF

Pharmaceutical products:

None