All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

mebanazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
monoamine oxidase inhibitors, hydrazine derivatives	4865	65-64-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: mebanazine monooxalate mebanazine sulfate mebanazine monosulfate mebanazine oxalate mebanazine monohydrochloride mebanazine hydrochloride actomol mebanazine ICI-31397	Molecular weight: 136.20 Formula: C8H12N2 CLOGP: 1.01 LIPINSKI: 0 HAC: 2 HDO: 2 TPSA: 38.05 ALOGS: -1.11 ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK12,MAPK7,MET,NTRK2,PDK2,PDK4,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1	40
kinase-selectivity-class	AKT2,AKT3,AXL,BRAF,FLT3,GRK2,PDK4,SIK2	8
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Depressive disorder	indication	35489007

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.35	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Amine oxidase [flavin-containing] B	Enzyme	P27338	AOFB_HUMAN	INHIBITOR				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Amine oxidase [flavin-containing] A	Enzyme	P21397	AOFA_HUMAN	INHIBITOR				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
Z5R55CJ4CG	UNII
3979-76-8	SECONDARY_CAS_RN
34675-74-6	SECONDARY_CAS_RN
29248-55-3	SECONDARY_CAS_RN
C0065831	UMLSCUI
CHEBI:134728	CHEBI
CHEMBL1909283	ChEMBL_ID
6179	PUBCHEM_CID
DB09248	DRUGBANK_ID
1722	INN_ID
C004343	MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None