estrone sulphate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
estrogens 4857 7280-37-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • estrone sulphate
  • estrone sodium sulfate
  • estropipate
  • piperazine estrone sulfate
  • sodium estrone sulfate
used therapeutically in menopausal patients
  • Molecular weight: 350.43
  • Formula: C18H22O5S
  • CLOGP: 1.82
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 80.67
  • ALOGS: -4.77
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 19, 1977 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003270 Contraceptive Agents
MeSH PA D000080066 Contraceptive Agents, Hormonal
MeSH PA D012102 Reproductive Control Agents
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Female hypogonadism syndrome indication 16041008
Atrophic vaginitis indication 52441000

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Estrogen receptor Nuclear hormone receptor AGONIST DRUG LABEL DRUG LABEL
Estrogen receptor beta Nuclear hormone receptor AGONIST DRUG LABEL DRUG LABEL
Steryl-sulfatase Enzyme Ki 4.22 CHEMBL
Solute carrier family 22 member 20 Transporter Ki 4.24 CHEMBL

External reference:

IDSource
D00948 KEGG_DRUG
4018490 VUID
N0000146812 NUI
438-67-5 SECONDARY_CAS_RN
4018490 VANDF
4018711 VANDF
C0304783 UMLSCUI
CHEBI:8389 CHEBI
CHEMBL2106240 ChEMBL_ID
CHEMBL494753 ChEMBL_ID
CHEMBL1200980 ChEMBL_ID
DB04574 DRUGBANK_ID
C009927 MESH_SUPPLEMENTAL_RECORD_UI
3001028 PUBCHEM_CID
6K6FDA543A UNII
33747 RXNORM
17244 MMSL
2464 MMSL
4689 MMSL
d00543 MMSL
001287 NDDF
115502007 SNOMEDCT_US
127381003 SNOMEDCT_US
395829001 SNOMEDCT_US
784234005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Esterified Estrogens and Methyltestosterone HUMAN PRESCRIPTION DRUG LABEL 2 50220-001 TABLET, FILM COATED 0.63 mg ORAL Unapproved drug other 13 sections
Esterified Estrogens and Methyltestosterone HUMAN PRESCRIPTION DRUG LABEL 2 50220-002 TABLET, FILM COATED 1.25 mg ORAL Unapproved drug other 13 sections
Estropipate HUMAN PRESCRIPTION DRUG LABEL 1 54868-3114 TABLET 0.75 mg ORAL ANDA 23 sections
Estropipate HUMAN PRESCRIPTION DRUG LABEL 1 54868-4149 TABLET 1.50 mg ORAL ANDA 23 sections
Estropipate HUMAN PRESCRIPTION DRUG LABEL 1 54868-4761 TABLET 3 mg ORAL ANDA 23 sections