seractide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
synthetic polypeptides with a corticotropin-like action 4821 39295-97-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • seractide
  • seractide acetate
  • seractide acetate hydrate
  • acthar gel-synthetic
  • Molecular weight: 4541.14
  • Formula: C207H308N56O58S
  • CLOGP:
  • LIPINSKI: None
  • HAC: 114
  • HDO: 63
  • TPSA: 1836.25
  • ALOGS:
  • ROTB: 145

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 21, 1978 FDA ARMOUR PHARM

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.04 acidic
pKa2 3.37 acidic
pKa3 3.56 acidic
pKa4 3.89 acidic
pKa5 4.04 acidic
pKa6 4.19 acidic
pKa7 4.43 acidic
pKa8 9.43 acidic
pKa9 10.05 acidic
pKa10 12.17 acidic
pKa11 12.36 acidic
pKa12 12.56 acidic
pKa13 12.83 acidic
pKa14 12.9 acidic
pKa15 13.02 acidic
pKa16 13.09 acidic
pKa17 13.32 acidic
pKa18 13.37 acidic
pKa19 13.42 acidic
pKa20 13.63 acidic
pKa21 13.64 acidic
pKa22 13.7 acidic
pKa23 13.76 acidic
pKa24 13.79 acidic
pKa25 13.9 acidic
pKa26 13.93 acidic
pKa27 11.5 Basic
pKa28 11.26 Basic
pKa29 11.01 Basic
pKa30 10.81 Basic
pKa31 10.55 Basic
pKa32 10.3 Basic
pKa33 9.94 Basic
pKa34 7.62 Basic
pKa35 6.69 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adrenocorticotropic hormone receptor GPCR AGONIST Ki 8.01 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D05827 KEGG_DRUG
63304-56-3 SECONDARY_CAS_RN
C1883003 UMLSCUI
CHEBI:136033 CHEBI
CHEMBL1201489 ChEMBL_ID
118984407 PUBCHEM_CID
6966 IUPHAR_LIGAND_ID
3532 INN_ID
DB09334 DRUGBANK_ID
IGM44CEY2I UNII
1999800 RXNORM

Pharmaceutical products:

None