levobetaxolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 4752 93221-48-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • levobetaxolol
  • levobetaxolol hydrochloride
  • (-)-Betaxolol
  • betaxon
  • levobetaxolol HCl
  • Molecular weight: 307.43
  • Formula: C18H29NO3
  • CLOGP: 2.32
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 50.72
  • ALOGS: -4.01
  • ROTB: 11

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 23, 2000 FDA ALCON PHARMS LTD

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ocular hypertension indication 4210003 DOID:9282
Open-angle glaucoma indication 84494001 DOID:1067

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 9.10 IUPHAR CHEMBL
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 7.49 IUPHAR

External reference:

IDSource
D04710 KEGG_DRUG
116209-55-3 SECONDARY_CAS_RN
C0875977 UMLSCUI
CHEBI:59254 CHEBI
60657 PUBCHEM_CID
CHEMBL1200837 ChEMBL_ID
CHEMBL1201274 ChEMBL_ID
DB09351 DRUGBANK_ID
8035 IUPHAR_LIGAND_ID
6447 INN_ID
75O9XHA4TU UNII
261465 RXNORM
31822 MMSL
8731 MMSL
409277002 SNOMEDCT_US
409278007 SNOMEDCT_US

Pharmaceutical products:

None