levobetaxolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
beta-adrenoreceptor antagonists	4752	93221-48-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

levobetaxolol
levobetaxolol hydrochloride
(-)-Betaxolol
betaxon
levobetaxolol HCl

Molecular weight: 307.43
Formula: C18H29NO3
CLOGP: 2.32
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 50.72
ALOGS: -4.01
ROTB: 11

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Feb. 23, 2000	FDA	ALCON PHARMS LTD

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ocular hypertension	indication	4210003	DOID:9282
Open-angle glaucoma	indication	84494001	DOID:1067

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.19	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN	ANTAGONIST	Ki	9.10		IUPHAR	CHEMBL
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN	ANTAGONIST	Ki	7.49		IUPHAR

External reference:

ID	Source
D04710	KEGG_DRUG
116209-55-3	SECONDARY_CAS_RN
CHEBI:59254	CHEBI
CHEMBL1201274	ChEMBL_ID
8035	IUPHAR_LIGAND_ID
6447	INN_ID
DB09351	DRUGBANK_ID
75O9XHA4TU	UNII
261465	RXNORM
31822	MMSL
8731	MMSL
409277002	SNOMEDCT_US
409278007	SNOMEDCT_US
C1171274	UMLSCUI
CHEMBL1200837	ChEMBL_ID
60657	PUBCHEM_CID

Pharmaceutical products:

None