sodium aurothiomalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4706 12244-57-4

Description:

MoleculeDescription

Synonyms:

  • sodium aurothiomalate
  • aurolate
  • aurothiomalate sodium
  • gold sodium thiomalate
  • sodium aurithiomalate
  • myochrysine
A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.
  • Molecular weight: 390.07
  • Formula: C4H3AuNa2O4S
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 80.26
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
2.40 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 70 % Benet LZ, Broccatelli F, Oprea TI

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1992 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
C-reactive protein increased 772.32 79.60 1023 108875 180366 90338183
Nail disorder 733.31 79.60 593 109305 58474 90460075
Inflammation 678.13 79.60 953 108945 177639 90340910
Blepharospasm 663.75 79.60 545 109353 54900 90463649
Onychomadesis 662.10 79.60 504 109394 45494 90473055
Back injury 557.41 79.60 458 109440 46164 90472385
Breast cancer stage III 544.95 79.60 589 109309 83858 90434691
Taste disorder 541.79 79.60 508 109390 61038 90457511
Adverse reaction 533.00 79.60 372 109526 29340 90489209
Treatment failure 503.87 79.60 1127 108771 302801 90215748
Onychomycosis 495.27 79.60 390 109508 36986 90481563
Finger deformity 492.27 79.60 369 109529 32528 90486021
Blood parathyroid hormone decreased 477.21 79.60 252 109646 11964 90506585
Epilepsy 474.62 79.60 541 109357 81665 90436884
Psoriatic arthropathy 465.90 79.60 922 108976 227413 90291136
Granuloma skin 462.21 79.60 236 109662 10444 90508105
Synovitis 444.11 79.60 1128 108770 328624 90189925
Panniculitis 440.13 79.60 253 109645 14205 90504344
Contraindicated product administered 438.30 79.60 1102 108796 319037 90199512
Facet joint syndrome 432.30 79.60 564 109334 97825 90420724
Peripheral venous disease 427.50 79.60 518 109380 83403 90435146
Product quality issue 426.04 79.60 503 109395 78822 90439727
Product label confusion 418.98 79.60 290 109608 22560 90495989
Osteoarthritis 418.21 79.60 806 109092 194924 90323625
Rheumatoid nodule 400.77 79.60 269 109629 19897 90498652
Bursitis 385.89 79.60 623 109275 131031 90387518
Pyrexia 385.10 79.60 160 109738 660325 89858224
C-reactive protein abnormal 368.02 79.60 599 109299 126830 90391719
Hypercholesterolaemia 358.41 79.60 522 109376 100370 90418179
Drug hypersensitivity 349.40 79.60 1294 108604 462315 90056234
Skin necrosis 348.74 79.60 231 109667 16710 90501839
Joint range of motion decreased 345.72 79.60 603 109295 135040 90383509
Obesity 344.87 79.60 525 109373 104982 90413567
Sleep disorder 330.72 79.60 737 109161 197293 90321256
Lip dry 329.47 79.60 502 109396 100453 90418096
Drug intolerance 324.50 79.60 1234 108664 446357 90072192
Therapeutic product effect decreased 323.22 79.60 900 108998 276671 90241878
Constipation 318.76 79.60 4 109894 280391 90238158
Urinary tract infection 311.33 79.60 14 109884 305618 90212931
Therapeutic product effect incomplete 310.82 79.60 710 109188 193186 90325363
Red blood cell sedimentation rate increased 308.94 79.60 438 109460 82157 90436392
Liver function test increased 305.67 79.60 442 109456 84413 90434136
Hepatitis 305.19 79.60 402 109496 70337 90448212
Wound infection 302.89 79.60 497 109401 105905 90412644
Coeliac disease 301.46 79.60 319 109579 44291 90474258
Grip strength decreased 298.78 79.60 458 109440 92118 90426431
Blood cholesterol increased 294.77 79.60 726 109172 207286 90311263
Hypotension 293.12 79.60 28 109870 325369 90193180
Arthropathy 280.47 79.60 1028 108870 365214 90153335
Musculoskeletal pain 276.54 79.60 629 109269 170622 90347927
Night sweats 273.27 79.60 529 109369 128237 90390312
Joint swelling 272.23 79.60 1269 108629 502031 90016518
Fibromyalgia 270.40 79.60 699 109199 205570 90312979
Gastrooesophageal reflux disease 267.53 79.60 610 109288 165727 90352822
Type 2 diabetes mellitus 264.62 79.60 687 109211 202557 90315992
Live birth 257.55 79.60 393 109505 78714 90439835
Toxicity to various agents 253.42 79.60 27 109871 287819 90230730
Basal cell carcinoma 251.29 79.60 253 109645 33136 90485413
Gait inability 244.31 79.60 545 109353 145911 90372638
Neck pain 241.56 79.60 468 109430 113495 90405054
Infusion site reaction 240.04 79.60 193 109705 18846 90499703
Death 237.54 79.60 129 109769 456422 90062127
Hypercalcaemia 236.95 79.60 248 109650 33992 90484557
Lung disorder 233.64 79.60 543 109355 149340 90369209
Ulcer 232.64 79.60 241 109657 32641 90485908
Drug eruption 231.81 79.60 249 109649 35158 90483391
Cough 228.59 79.60 81 109817 368881 90149668
Neutropenia 226.72 79.60 11 109887 224893 90293656
Folliculitis 223.43 79.60 648 109250 203705 90314844
Thrombocytopenia 217.74 79.60 8 109890 208717 90309832
Peripheral swelling 210.34 79.60 1024 108874 412082 90106467
Drug-induced liver injury 210.12 79.60 386 109512 89932 90428617
Rheumatoid arthritis 208.95 79.60 932 108966 361682 90156867
Dyspnoea 205.85 79.60 480 109418 880475 89638074
Back pain 204.52 79.60 65 109833 317110 90201439
Anti-cyclic citrullinated peptide antibody positive 204.32 79.60 691 109207 235742 90282807
Anaemia 196.48 79.60 91 109807 352711 90165838
Injection site reaction 193.71 79.60 377 109521 91703 90426846
Mobility decreased 183.50 79.60 694 109204 250040 90268509
Skin ulcer 180.50 79.60 261 109637 49814 90468735
Musculoskeletal stiffness 179.74 79.60 774 109124 295758 90222791
Infusion related reaction 176.73 79.60 982 108916 415798 90102751
Deafness transitory 176.48 79.60 73 109825 1970 90516579
Loss of personal independence in daily activities 174.90 79.60 458 109440 135647 90382902
Anxiety 173.86 79.60 79 109819 309693 90208856
Dry mouth 172.44 79.60 553 109345 183506 90335043
Abdominal distension 170.40 79.60 442 109456 130159 90388390
Intentional product use issue 167.58 79.60 611 109287 216281 90302268
Memory impairment 167.30 79.60 573 109325 196671 90321878
Liver injury 164.83 79.60 518 109380 170049 90348500
Pruritus 164.06 79.60 252 109646 541273 89977276
Pericarditis 156.71 79.60 696 109202 269455 90249094
Muscle injury 154.92 79.60 519 109379 176135 90342414
Soft tissue disorder 154.90 79.60 84 109814 4206 90514343
Musculoskeletal disorder 154.78 79.60 160 109738 21609 90496940
General physical health deterioration 154 79.60 842 109056 354273 90164276
Helicobacter infection 151.39 79.60 610 109288 226240 90292309
Drug tolerance decreased 150.11 79.60 190 109708 31940 90486609
Blood pressure increased 149.17 79.60 29 109869 197188 90321361
Palpitations 147.02 79.60 4 109894 136724 90381825
Irritable bowel syndrome 144.99 79.60 566 109332 206882 90311667
Duodenal ulcer perforation 143.66 79.60 590 109308 220698 90297851
Myalgia 142.94 79.60 21 109877 175104 90343445
Rheumatic fever 140.62 79.60 457 109441 152664 90365885
Adverse event 140.62 79.60 385 109513 117033 90401516
Haemoglobin decreased 140.42 79.60 16 109882 161940 90356609
Hand deformity 138.89 79.60 718 109180 295644 90222905
Hepatic enzyme increased 138.47 79.60 828 109070 359908 90158641
Syncope 135.25 79.60 6 109892 132657 90385892
Presbyacusis 133.87 79.60 68 109830 2974 90515575
Gastrointestinal disorder 132.36 79.60 639 109259 256048 90262501
Pancytopenia 131.28 79.60 3 109895 120260 90398289
Oedema peripheral 130.92 79.60 75 109823 257840 90260709
Pemphigus 130.41 79.60 758 109140 326106 90192443
Dyspepsia 128.33 79.60 528 109370 197632 90320917
Pleural fibrosis 125.92 79.60 69 109829 3527 90515022
Oropharyngeal pain 125.24 79.60 3 109895 115184 90403365
Drug tolerance 124.36 79.60 130 109768 17786 90500763
Pleural thickening 124.00 79.60 66 109832 3182 90515367
Sepsis 122.89 79.60 33 109865 179781 90338768
Dysphagia 121.79 79.60 3 109895 112275 90406274
Weight decreased 121.60 79.60 170 109728 379740 90138809
Blood magnesium increased 121.02 79.60 66 109832 3342 90515207
Hyperhidrosis 119.34 79.60 13 109885 136292 90382257
Glossodynia 116.74 79.60 728 109170 321051 90197498
Rash pruritic 114.21 79.60 285 109613 81929 90436620
Functional gastrointestinal disorder 113.90 79.60 73 109825 4989 90513560
Lower respiratory tract infection 113.76 79.60 602 109296 250057 90268492
Product use issue 113.25 79.60 736 109162 329183 90189366
Impaired healing 106.62 79.60 563 109335 233636 90284913
Fatigue 106.43 79.60 893 109005 1153130 89365419
Hypokalaemia 106.35 79.60 16 109882 131100 90387449
Wound 105.25 79.60 678 109220 302302 90216247
Tenosynovitis 105.25 79.60 108 109790 14459 90504090
Pleural effusion 105.22 79.60 8 109890 111983 90406566
Injury 105.10 79.60 496 109402 196853 90321696
Chills 105.02 79.60 17 109881 131964 90386585
Feeling abnormal 104.69 79.60 36 109862 167199 90351350
Balance disorder 103.77 79.60 3 109895 97077 90421472
Stomatitis 101.17 79.60 624 109274 274074 90244475
Therapeutic response decreased 100.31 79.60 287 109611 89442 90429107
Red blood cell sedimentation rate 99.46 79.60 65 109833 4593 90513956
Pulmonary embolism 97.31 79.60 20 109878 130800 90387749
Demyelination 97.29 79.60 80 109818 8060 90510489
Tachycardia 96.88 79.60 35 109863 157638 90360911
Inappropriate schedule of product administration 94.32 79.60 32 109866 149901 90368648
Gastrointestinal pain 93.77 79.60 90 109808 11116 90507433
Gastric disorder 93.64 79.60 155 109743 33229 90485320
Systemic lupus erythematosus 91.23 79.60 750 109148 361146 90157403
Platelet count decreased 90.13 79.60 27 109871 136942 90381607
Condition aggravated 90.00 79.60 1110 108788 594435 89924114
Heart rate increased 88.81 79.60 15 109883 112887 90405662
Chest pain 87.16 79.60 159 109739 319486 90199063
Hypocholesterolaemia 86.91 79.60 68 109830 6381 90512168
Deafness neurosensory 85.48 79.60 69 109829 6772 90511777
Stress 85.26 79.60 3 109895 81392 90437157
Congenital anomaly 83.54 79.60 66 109832 6281 90512268
Asthma 82.91 79.60 103 109795 242057 90276492
Migraine 80.08 79.60 448 109450 189944 90328605

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Joint swelling 562.08 126.15 261 7166 67761 42546147
Red blood cell sedimentation rate increased 536.14 126.15 153 7274 9771 42604137
Apparent death 508.52 126.15 120 7307 3588 42610320
Arthropathy 466.69 126.15 180 7247 29417 42584491
Pulmonary thrombosis 420.81 126.15 122 7305 8226 42605682
Contraindicated product administered 395.74 126.15 153 7274 25119 42588789
C-reactive protein abnormal 369.57 126.15 113 7314 9148 42604760
Terminal state 325.46 126.15 87 7340 4336 42609572
Diverticulitis 318.16 126.15 127 7300 22646 42591262
C-reactive protein increased 287.95 126.15 163 7264 63397 42550511
Drug ineffective 259.90 126.15 420 7007 629777 41984131
Rheumatoid factor negative 238.27 126.15 51 7376 963 42612945
Red blood cell sedimentation rate abnormal 228.89 126.15 64 7363 3772 42610136
Bone erosion 206.94 126.15 61 7366 4342 42609566
Drug intolerance 206.64 126.15 144 7283 80280 42533628
Photosensitivity reaction 198.89 126.15 77 7350 12625 42601283
Drug tolerance decreased 195.42 126.15 51 7376 2309 42611599
Hand deformity 184.97 126.15 54 7373 3714 42610194
Thrombosis 183.74 126.15 126 7301 68385 42545523
Treatment failure 179.43 126.15 120 7307 62504 42551404
Intestinal sepsis 177.73 126.15 38 7389 713 42613195
Drug hypersensitivity 177.27 126.15 143 7284 99246 42514662
Deep vein thrombosis 170.54 126.15 126 7301 76831 42537077
Herpes zoster 150.04 126.15 90 7337 38787 42575121
Therapeutic product effect decreased 141.74 126.15 87 7340 39063 42574845
Joint arthroplasty 141.05 126.15 33 7394 944 42612964
Ill-defined disorder 138.47 126.15 64 7363 16232 42597676
Limb discomfort 133.56 126.15 58 7369 12709 42601199
Musculoskeletal discomfort 132.67 126.15 53 7374 9423 42604485

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
C-reactive protein increased 908.99 103.51 1099 108458 216820 110262922
Contraindicated product administered 876.55 103.51 1152 108405 247115 110232627
Nail disorder 862.23 103.51 598 108959 57337 110422405
Treatment failure 757.78 103.51 1138 108419 276096 110203646
Onychomadesis 754.76 103.51 503 109054 45160 110434582
Blepharospasm 753.13 103.51 539 109018 54312 110425430
Synovitis 705.14 103.51 1094 108463 272998 110206744
Arthropathy 694.63 103.51 1115 108442 286407 110193335
Inflammation 693.03 103.51 904 108653 192334 110287408
Psoriatic arthropathy 657.18 103.51 889 108668 195872 110283870
Breast cancer stage III 644.39 103.51 572 108985 78545 110401197
Back injury 628.33 103.51 456 109101 46943 110432799
Joint swelling 612.22 103.51 1352 108205 441493 110038249
C-reactive protein abnormal 603.11 103.51 692 108865 129003 110350739
Taste disorder 591.57 103.51 502 109055 64885 110414857
Drug intolerance 579.85 103.51 1257 108300 405255 110074487
Osteoarthritis 570.44 103.51 799 108758 181824 110297918
Onychomycosis 569.13 103.51 396 109161 38135 110441607
Adverse reaction 567.65 103.51 358 109199 29236 110450506
Drug hypersensitivity 553.19 103.51 1319 108238 452771 110026971
Finger deformity 552.76 103.51 367 109190 32725 110447017
Red blood cell sedimentation rate increased 521.33 103.51 506 109051 77796 110401946
Therapeutic product effect decreased 520.73 103.51 896 108661 243420 110236322
Facet joint syndrome 510.87 103.51 552 109005 96276 110383466
Pyrexia 489.84 103.51 142 109415 898123 109581619
Product quality issue 489.43 103.51 486 109071 76813 110402929
Peripheral venous disease 485.41 103.51 503 109054 83614 110396128
Hypercholesterolaemia 484.75 103.51 521 109036 90316 110389426
Product label confusion 474.59 103.51 290 109267 22387 110457355
Bursitis 468.89 103.51 610 108947 129308 110350434
Epilepsy 467.98 103.51 536 109021 99673 110380069
Blood parathyroid hormone decreased 464.84 103.51 237 109320 12852 110466890
Joint range of motion decreased 461.60 103.51 586 108971 121246 110358496
Granuloma skin 452.89 103.51 222 109335 11061 110468681
Panniculitis 428.72 103.51 238 109319 15344 110464398
Liver function test increased 427.65 103.51 482 109075 88066 110391676
Type 2 diabetes mellitus 422.92 103.51 684 108873 176548 110303194
Sleep disorder 421.11 103.51 727 108830 197917 110281825
Wound infection 418.75 103.51 497 109060 95968 110383774
Grip strength decreased 415.77 103.51 453 109104 79721 110400021
Rheumatoid nodule 413.11 103.51 255 109302 20041 110459701
Anti-cyclic citrullinated peptide antibody positive 409.51 103.51 684 108873 181300 110298442
Pemphigus 405.71 103.51 747 108810 213823 110265919
Obesity 402.42 103.51 528 109029 112823 110366919
Hypotension 401.70 103.51 31 109526 523818 109955924
Toxicity to various agents 393.63 103.51 20 109537 480535 109999207
Fibromyalgia 393.42 103.51 649 108908 170260 110309482
Folliculitis 393.15 103.51 642 108915 167011 110312731
Lip dry 384.78 103.51 485 109072 99598 110380144
Blood cholesterol increased 384.75 103.51 671 108886 184114 110295628
Hand deformity 381.19 103.51 735 108822 217771 110261971
Coeliac disease 369.04 103.51 321 109236 42866 110436876
Glossodynia 364.52 103.51 728 108829 221276 110258466
Anaemia 359.95 103.51 56 109501 547030 109932712
Gait inability 358.03 103.51 550 109007 135826 110343916
Rheumatoid arthritis 356.37 103.51 863 108694 298750 110180992
Neutropenia 336.94 103.51 7 109550 374613 110105129
Apparent death 334.45 103.51 121 109436 2781 110476961
Constipation 333.07 103.51 4 109553 357782 110121960
Death 331.57 103.51 139 109418 698730 109781012
Night sweats 330.35 103.51 525 109032 133458 110346284
Live birth 326.58 103.51 373 109184 69111 110410631
Musculoskeletal pain 318.33 103.51 615 108942 182408 110297334
Pericarditis 317.97 103.51 683 108874 218431 110261311
Helicobacter infection 317.37 103.51 612 108945 181265 110298477
Thrombocytopenia 311.86 103.51 7 109550 348878 110130864
Systemic lupus erythematosus 310.31 103.51 740 108817 253598 110226144
Skin necrosis 308.07 103.51 217 109340 21295 110458447
Infusion related reaction 307.45 103.51 952 108605 380210 110099532
Gastrooesophageal reflux disease 307.20 103.51 600 108957 179376 110300366
Peripheral swelling 303.85 103.51 985 108572 403049 110076693
Urinary tract infection 302.13 103.51 4 109553 326278 110153464
Muscle injury 299.12 103.51 516 109041 140291 110339451
Mobility decreased 298.54 103.51 699 108858 236723 110243019
Hepatitis 283.84 103.51 396 109161 89658 110390084
Irritable bowel syndrome 283.34 103.51 550 109007 163665 110316077
Neck pain 282.46 103.51 467 109090 122663 110357079
Hepatic enzyme increased 281.80 103.51 826 108731 320066 110159676
Duodenal ulcer perforation 281.18 103.51 574 108983 177126 110302616
Therapeutic product effect incomplete 279.27 103.51 657 108900 223148 110256594
Wound 276.17 103.51 673 108884 233764 110245978
Drug tolerance decreased 275.07 103.51 224 109333 27316 110452426
Musculoskeletal stiffness 271.72 103.51 747 108810 279075 110200667
Liver injury 269.58 103.51 512 109045 149901 110329841
Cough 266.22 103.51 65 109492 461576 110018166
Rheumatic fever 258.75 103.51 448 109109 122131 110357611
Intentional product use issue 257.96 103.51 679 108878 247227 110232515
Infusion site reaction 245.41 103.51 175 109382 17507 110462235
Injection site reaction 240.41 103.51 364 109193 88706 110391036
Dyspnoea 232.74 103.51 467 109090 1106405 109373337
Memory impairment 230.42 103.51 564 108993 196380 110283362
Impaired healing 228.72 103.51 562 108995 196155 110283587
Lung disorder 227.22 103.51 531 109026 179516 110300226
Swelling 221.06 103.51 807 108750 350234 110129508
Stomatitis 216.77 103.51 674 108883 269568 110210174
Skin ulcer 214.28 103.51 289 109268 63356 110416386
Loss of personal independence in daily activities 211.06 103.51 462 109095 149558 110330184
Basal cell carcinoma 204.24 103.51 238 109319 45032 110434710
Ill-defined disorder 202.72 103.51 467 109090 156386 110323356
Gastrointestinal disorder 202.00 103.51 612 108945 241340 110238402
Dry mouth 196.17 103.51 536 109021 199412 110280330
Ulcer 195.06 103.51 227 109330 42889 110436853
Drug-induced liver injury 193.59 103.51 391 109166 119676 110360066
Pancytopenia 192.14 103.51 3 109554 209610 110270132
Hypercalcaemia 190.28 103.51 233 109324 46424 110433318
Adverse event 188.28 103.51 365 109192 108444 110371298
Terminal state 187.90 103.51 98 109459 5569 110474173
Abdominal discomfort 184.54 103.51 826 108731 393032 110086710
Dyspepsia 182.45 103.51 507 109050 190458 110289284
Hypersensitivity 180.89 103.51 836 108721 403162 110076580
Product use issue 180.75 103.51 698 108859 310997 110168745
Injury 176.67 103.51 478 109079 176787 110302955
Maternal exposure during pregnancy 175.85 103.51 604 108953 254279 110225463
Syncope 173.76 103.51 6 109551 202530 110277212
Alopecia 173.14 103.51 768 108789 363985 110115757
Lower respiratory tract infection 169.37 103.51 578 108979 242528 110237214
Drug eruption 166.11 103.51 234 109323 53425 110426317
Pulmonary thrombosis 162.64 103.51 124 109433 13739 110466003
Blood pressure increased 161.88 103.51 30 109527 258343 110221399
General physical health deterioration 161.73 103.51 840 108717 424455 110055287
Back pain 159.92 103.51 84 109473 370912 110108830
Weight decreased 156.51 103.51 140 109417 467917 110011825
Anxiety 156.48 103.51 73 109484 345005 110134737
Blister 156.10 103.51 538 109019 226838 110252904
Intestinal sepsis 150.80 103.51 51 109506 953 110478789
Myalgia 150.13 103.51 21 109536 222360 110257382
Migraine 149.64 103.51 441 109116 171211 110308531
Abdominal distension 148.03 103.51 445 109112 174658 110305084
Urticaria 144.24 103.51 662 108895 318195 110161547
Oedema peripheral 142.25 103.51 74 109483 328586 110151156
Pleural effusion 140.42 103.51 9 109548 177700 110302042
Presbyacusis 139.25 103.51 64 109493 2755 110476987
Palpitations 139.14 103.51 4 109553 159208 110320534
Gastrointestinal haemorrhage 138.24 103.51 6 109551 165512 110314230
Pruritus 137.33 103.51 228 109329 581332 109898410
Musculoskeletal disorder 136.92 103.51 139 109418 22525 110457217
Chills 131.01 103.51 17 109540 190563 110289179
Deafness transitory 127.55 103.51 46 109511 1047 110478695
Septic shock 127.43 103.51 7 109550 157521 110322221
Hypokalaemia 126.08 103.51 16 109541 182432 110297310
Disease progression 124.69 103.51 43 109514 243991 110235751
Tachycardia 124.64 103.51 35 109522 226610 110253132
Hypoaesthesia 123.08 103.51 626 108931 313597 110166145
Drug tolerance 119.44 103.51 112 109445 16473 110463269
Pleural thickening 119.09 103.51 61 109496 3338 110476404
Gastric disorder 117.67 103.51 155 109402 33202 110446540
Pleural fibrosis 113.58 103.51 64 109493 4244 110475498
Inappropriate schedule of product administration 112.81 103.51 31 109526 203606 110276136
Blood magnesium increased 112.33 103.51 61 109496 3762 110475980
Hypertension 109.15 103.51 871 108686 509213 109970529
Rheumatoid factor negative 105.65 103.51 42 109515 1258 110478484
Therapeutic response decreased 105.03 103.51 269 109288 96230 110383512
Bone erosion 103.74 103.51 174 109383 46197 110433545

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01CB01 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
SPECIFIC ANTIRHEUMATIC AGENTS
Gold preparations
MeSH PA D018501 Antirheumatic Agents
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:37670 protease inhibitor
CHEBI has role CHEBI:50904 allergen
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:131699 EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor
CHEBI has role CHEBI:35610 antineoplastic agent

Related Drugs by ATC class:

M01CB Gold preparations 4 drugs
auranofinaurothioglucoseaurotioprolsodium aurotiosulfate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148
Juvenile rheumatoid arthritis indication 410795001
Psoriasis with arthropathy off-label use 33339001
Felty's syndrome off-label use 57160007 DOID:11042




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Adenosine receptor A3 GPCR Ki 6.07 DRUG MATRIX
Thioredoxin reductase 1, cytoplasmic Enzyme WOMBAT-PK
Epidermal growth factor receptor Kinase IC50 5.62 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 6.09 DRUG MATRIX
Cathepsin L1 Enzyme IC50 4.05 CHEMBL

External reference:

IDSource
D00992 KEGG_DRUG
4017995 VUID
N0000146340 NUI
4017995 VANDF
CHEBI:5516 CHEBI
CHEMBL306043 ChEMBL_ID
DB09276 DRUGBANK_ID
203004 RXNORM
2006 MMSL
4795 MMSL
615 MMSL
620 MMSL
d00250 MMSL
002396 NDDF
387380005 SNOMEDCT_US
68702006 SNOMEDCT_US
C0018034 UMLSCUI
D006052 MESH_DESCRIPTOR_UI
22318 PUBCHEM_CID
4154 INN_ID
E4768ZY6GM UNII

Pharmaceutical products:

None