nalfurafine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
opioid receptor antagonists/agonists related to normorphine 4673 152657-84-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • TRK-820
  • winfuran
  • remitch
  • nalfurafine
  • nalfurafine hydrochloride
  • nalfurafine HCl
  • Molecular weight: 476.57
  • Formula: C28H32N2O5
  • CLOGP: 2.67
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 86.38
  • ALOGS: -3.47
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 21, 2009 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AX02 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Other therapeutic products

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Severe Pruritus indication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.64 acidic
pKa2 7.76 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Kappa-type opioid receptor GPCR AGONIST Ki 9.64 CHEMBL SCIENTIFIC LITERATURE
Delta-type opioid receptor GPCR EC50 7.13 CHEMBL
Mu-type opioid receptor GPCR EC50 9.14 CHEMBL
Nociceptin receptor GPCR Ki 6.83 PDSP
Kappa-type opioid receptor GPCR Ki 9.75 CHEMBL
Delta-type opioid receptor GPCR Ki 7.29 CHEMBL
Mu-type opioid receptor GPCR Ki 9.24 CHEMBL
Mu-type opioid receptor GPCR Ki 9.37 CHEMBL
Delta-type opioid receptor GPCR Ki 9.43 CHEMBL
Kappa-type opioid receptor GPCR Ki 9.75 CHEMBL

External reference:

IDSource
D06405 KEGG_DRUG
152658-17-8 SECONDARY_CAS_RN
C2825264 UMLSCUI
CHEBI:136019 CHEBI
CHEMBL267495 ChEMBL_ID
CHEMBL490665 ChEMBL_ID
CHEMBL485605 ChEMBL_ID
DB13471 DRUGBANK_ID
C111212 MESH_SUPPLEMENTAL_RECORD_UI
1651 IUPHAR_LIGAND_ID
8209 INN_ID
XC41AVD567 UNII
6445230 PUBCHEM_CID

Pharmaceutical products:

None