DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
nalfurafine 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
opioid receptor antagonists/agonists related to normorphine
4673
152657-84-6
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
TRK-820
winfuran
remitch
nalfurafine
nalfurafine hydrochloride
nalfurafine HCl
Molecular weight: 476.57
Formula: C28H32N2O5
CLOGP: 2.33
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 86.38
ALOGS: -3.47
ROTB: 5
Drug dosage:
None
ADMET properties:
None
Approvals:
Show
10
25
50
100
entries
Search:
Date
Agency
Company
Orphan
Jan. 21, 2009
PMDA
Showing 1 to 1 of 1 entries
Previous
1
Next
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
Show
10
25
50
100
entries
Search:
Source
Code
Description
ATC
V03AX02
VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Other therapeutic products
Showing 1 to 1 of 1 entries
Previous
1
Next
Drug Use
| Suggest Off label Use Form|
|View source of the data|
Show
10
25
50
100
entries
Search:
Disease
Relation
SNOMED_ID
DOID
Severe Pruritus
indication
Showing 1 to 1 of 1 entries
Previous
1
Next
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
Show
10
25
50
100
entries
Search:
Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
10.64
acidic
pKa2
7.76
Basic
Showing 1 to 2 of 2 entries
Previous
1
Next
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
Show
10
25
50
100
entries
Search:
Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Kappa-type opioid receptor
GPCR
P41145
OPRK_HUMAN
AGONIST
Ki
9.64
CHEMBL
SCIENTIFIC LITERATURE
Mu-type opioid receptor
GPCR
P35372
OPRM_HUMAN
EC50
9.14
CHEMBL
Delta-type opioid receptor
GPCR
P41143
OPRD_HUMAN
EC50
7.13
CHEMBL
Nociceptin receptor
GPCR
P41146
OPRX_HUMAN
Ki
6.83
PDSP
Mitogen-activated protein kinase 3
Kinase
P27361
MK03_HUMAN
EC50
9.26
CHEMBL
Mitogen-activated protein kinase 1
Kinase
P28482
MK01_HUMAN
EC50
9.26
CHEMBL
Orexin receptor type 1
GPCR
O43613
OX1R_HUMAN
Ki
6.60
CHEMBL
Mu-type opioid receptor
GPCR
OPRM_MOUSE
Ki
9.37
CHEMBL
Delta-type opioid receptor
GPCR
OPRD_MOUSE
Ki
7.29
CHEMBL
Delta-type opioid receptor
GPCR
OPRD_RAT
Ki
9.43
CHEMBL
Showing 1 to 10 of 14 entries
Previous
1
2
Next
External reference:
Show
10
25
50
100
entries
Search:
ID
Source
IVB
PDB_CHEM_ID
152658-17-8
SECONDARY_CAS_RN
1651
IUPHAR_LIGAND_ID
6445230
PUBCHEM_CID
8209
INN_ID
C111212
MESH_SUPPLEMENTAL_RECORD_UI
C2825264
UMLSCUI
CHEBI:136019
CHEBI
CHEMBL267495
ChEMBL_ID
CHEMBL485605
ChEMBL_ID
Showing 1 to 10 of 14 entries
Previous
1
2
Next
Pharmaceutical products:
None
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
nalfurafine