nalfurafine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
opioid receptor antagonists/agonists related to normorphine	4673	152657-84-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

TRK-820
winfuran
remitch
nalfurafine
nalfurafine hydrochloride
nalfurafine HCl

Molecular weight: 476.57
Formula: C28H32N2O5
CLOGP: 2.33
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 86.38
ALOGS: -3.47
ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Jan. 21, 2009	PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	V03AX02	VARIOUS ALL OTHER THERAPEUTIC PRODUCTS ALL OTHER THERAPEUTIC PRODUCTS Other therapeutic products

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Severe Pruritus	indication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.64	acidic
pKa2	7.76	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Kappa-type opioid receptor	GPCR	P41145	OPRK_HUMAN	AGONIST	Ki	9.64		CHEMBL	SCIENTIFIC LITERATURE
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN		EC50	9.14		CHEMBL
Delta-type opioid receptor	GPCR	P41143	OPRD_HUMAN		EC50	7.13		CHEMBL
Nociceptin receptor	GPCR	P41146	OPRX_HUMAN		Ki	6.83		PDSP
Mitogen-activated protein kinase 3	Kinase	P27361	MK03_HUMAN		EC50	9.26		CHEMBL
Mitogen-activated protein kinase 1	Kinase	P28482	MK01_HUMAN		EC50	9.26		CHEMBL
Orexin receptor type 1	GPCR	O43613	OX1R_HUMAN		Ki	6.60		CHEMBL
Mu-type opioid receptor	GPCR		OPRM_MOUSE		Ki	9.37		CHEMBL
Delta-type opioid receptor	GPCR		OPRD_MOUSE		Ki	7.29		CHEMBL
Delta-type opioid receptor	GPCR		OPRD_RAT		Ki	9.43		CHEMBL
Kappa-type opioid receptor	GPCR		OPRK_CAVPO		Ki	9.75		CHEMBL
Kappa-type opioid receptor	GPCR		OPRK_RAT		EC50	9.30		CHEMBL
Kappa-type opioid receptor	GPCR		OPRK_MOUSE		Ki	9.75		CHEMBL
Mu-type opioid receptor	GPCR		OPRM_CAVPO		Ki	9.24		CHEMBL

External reference:

ID	Source
D06405	KEGG_DRUG
152658-17-8	SECONDARY_CAS_RN
CHEBI:136019	CHEBI
IVB	PDB_CHEM_ID
CHEMBL267495	ChEMBL_ID
CHEMBL490665	ChEMBL_ID
CHEMBL485605	ChEMBL_ID
C111212	MESH_SUPPLEMENTAL_RECORD_UI
1651	IUPHAR_LIGAND_ID
8209	INN_ID
DB13471	DRUGBANK_ID
XC41AVD567	UNII
C2825264	UMLSCUI
6445230	PUBCHEM_CID

Pharmaceutical products:

None