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phenylacetic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4624 | 103-82-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK | 37 | |||
| kinase-selectivity-class | AXL,EIF2AK3,GRK2,MAP2K6,TGFBR1 | 5 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 23, 1987 | FDA | B BRAUN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A16AX30 | ALIMENTARY TRACT AND METABOLISM OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS Various alimentary tract and metabolism products |
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D000964 | Antimetabolites, Antineoplastic |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D009676 | Noxae |
| FDA MoA | N0000175806 | Ammonium Ion Binding Activity |
| FDA EPC | N0000175807 | Nitrogen Binding Agent |
| CHEBI has role | CHEBI:22676 | auxin |
| CHEBI has role | CHEBI:27026 | toxin |
| CHEBI has role | CHEBI:35219 | plant growth retardant |
| CHEBI has role | CHEBI:50904 | allergen |
| CHEBI has role | CHEBI:75772 | <em>Saccharomyces cerevisiae </em> metabolite |
| CHEBI has role | CHEBI:76924 | plant metabolite |
| CHEBI has role | CHEBI:76956 | <em>Aspergillus </em> metabolite |
| CHEBI has role | CHEBI:76971 | <em>Escherichia coli</em> metabolite |
| CHEBI has role | CHEBI:77746 | human metabolite |
| CHEBI has role | CHEBI:90318 | EC 6.4.1.1 (pyruvate carboxylase) inhibitor |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
Related Drugs by ATC class:
A16AX Various alimentary tract and metabolism products 23 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hyperammonemia | indication | 9360008 | |
| Hypokalemia | contraindication | 43339004 | |
| Body fluid retention | contraindication | 43498006 | |
| Chronic heart failure | contraindication | 48447003 | |
| Acute nephropathy | contraindication | 58574008 | |
| Metabolic acidosis | contraindication | 59455009 | |
| Hyperglycemia | contraindication | 80394007 | DOID:4195 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Seizure disorder | contraindication | 128613002 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Edema | contraindication | 267038008 | |
| CNS Toxicity | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.37 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Aldose reductase | Enzyme | IC50 | 4.02 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D05867 | KEGG_DRUG |
| 114-70-5 | SECONDARY_CAS_RN |
| 4019576 | VANDF |
| CHEBI:30745 | CHEBI |
| CHEMBL1044 | ChEMBL_ID |
| CHEMBL1200358 | ChEMBL_ID |
| C025136 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB09269 | DRUGBANK_ID |
| ER5I1W795A | UNII |
| 33332 | RXNORM |
| 19292 | MMSL |
| d05460 | MMSL |
| 001244 | NDDF |
| 004954 | NDDF |
| 125705007 | SNOMEDCT_US |
| 398818001 | SNOMEDCT_US |
| C0070620 | UMLSCUI |
| PAC | PDB_CHEM_ID |
| 999 | PUBCHEM_CID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ammonul | HUMAN PRESCRIPTION DRUG LABEL | 2 | 62592-720 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | NDA | 28 sections |
| SODIUM PHENYLACETATE AND SODIUM BENZOATE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 68382-396 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | ANDA | 24 sections |
| Sodium Phenylacetate and sodium benzoate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 68475-001 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | ANDA | 24 sections |
| Sodium phenylacetate and Sodium benzoate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 68475-513 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | ANDA | 24 sections |
| SODIUM PHENYLACETATE AND SODIUM BENZOATE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 70511-101 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | ANDA | 28 sections |
| Sodium Phenylacetate and Sodium Benzoate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 70511-102 | INJECTION | 100 mg | INTRAVENOUS | NDA | 29 sections |
| SODIUM PHENYLACETATE and SODIUM BENZOATE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 70556-100 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | ANDA | 28 sections |
| Sodium phenylacetate and Sodium benzoate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 70710-1926 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | ANDA | 24 sections |
| Sodium Phenylacetate and Sodium Benzoate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 72266-236 | INJECTION | 100 mg | INTRAVENOUS | NDA | 29 sections |
| SODIUM PHENYLACETATE and SODIUM BENZOATE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 81665-203 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | ANDA | 28 sections |
| SODIUM PHENYLACETATE and SODIUM BENZOATE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 81665-204 | INJECTION, SOLUTION, CONCENTRATE | 100 mg | INTRAVENOUS | ANDA | 28 sections |