linolenic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4618 463-40-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • linolenic acid
  • alpha-Linolenic acid
  • linolenate
A fatty acid that is found in plants and involved in the formation of prostaglandins.
  • Molecular weight: 278.44
  • Formula: C18H30O2
  • CLOGP: 6.82
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -6.02
  • ROTB: 13

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.76 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme Ki 5.40 CHEMBL
Aromatase Enzyme IC50 4.35 CHEMBL
Peroxisome proliferator-activated receptor alpha Nuclear hormone receptor Kd 8.10 CHEMBL
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor Kd 5.70 CHEMBL
Fatty acid-binding protein, heart Cytosolic other Kd 8.56 CHEMBL
Peroxisome proliferator-activated receptor delta Nuclear hormone receptor IC50 4.80 CHEMBL
Free fatty acid receptor 1 GPCR EC50 5.52 CHEMBL
Tissue factor Membrane receptor IC50 4.52 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 4.92 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.03 CHEMBL

External reference:

IDSource
4020239 VUID
N0000148143 NUI
4020239 VANDF
CHEBI:27432 CHEBI
LNL PDB_CHEM_ID
CHEMBL8739 ChEMBL_ID
DB00132 DRUGBANK_ID
0RBV727H71 UNII
5280934 PUBCHEM_CID
52071 RXNORM
009723 NDDF
81868000 SNOMEDCT_US
D017962 MESH_DESCRIPTOR_UI
C0125903 UMLSCUI

Pharmaceutical products:

None