linolenic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4618 | 463-40-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A fatty acid that is found in plants and involved in the formation of prostaglandins.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:27027 | trace elements |
| CHEBI has role | CHEBI:50733 | Dietary Supplement |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.76 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 | Enzyme | Ki | 5.40 | CHEMBL | |||||
| Aromatase | Enzyme | IC50 | 4.35 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor alpha | Nuclear hormone receptor | Kd | 8.10 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | Kd | 5.70 | CHEMBL | |||||
| Fatty acid-binding protein, heart | Cytosolic other | Kd | 8.56 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor delta | Nuclear hormone receptor | IC50 | 4.80 | CHEMBL | |||||
| Free fatty acid receptor 1 | GPCR | EC50 | 5.52 | CHEMBL | |||||
| Tissue factor | Membrane receptor | IC50 | 4.52 | CHEMBL | |||||
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 4.92 | CHEMBL | |||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.03 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020239 | VUID |
| N0000148143 | NUI |
| 4020239 | VANDF |
| CHEBI:27432 | CHEBI |
| LNL | PDB_CHEM_ID |
| CHEMBL8739 | ChEMBL_ID |
| DB00132 | DRUGBANK_ID |
| 0RBV727H71 | UNII |
| 52071 | RXNORM |
| 009723 | NDDF |
| 81868000 | SNOMEDCT_US |
| C0125903 | UMLSCUI |
| D017962 | MESH_DESCRIPTOR_UI |
| 5280934 | PUBCHEM_CID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Anubis Barcelona Vital Line | HUMAN OTC DRUG LABEL | 23 | 83021-064 | CREAM | 0.04 g | TOPICAL | OTC monograph final | 5 sections |
| AnubisMed | HUMAN OTC DRUG LABEL | 28 | 83021-551 | CREAM | 0.00 g | TOPICAL | OTC monograph final | 7 sections |
| Anubis Barcelona Protective Line | HUMAN OTC DRUG LABEL | 27 | 83021-686 | CREAM | 0.00 g | TOPICAL | OTC monograph final | 9 sections |
| Anubis Barcelona Protective Line | HUMAN OTC DRUG LABEL | 27 | 83021-686 | CREAM | 0.00 g | TOPICAL | OTC monograph final | 9 sections |