linolenic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4618 463-40-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • linolenic acid
  • alpha-Linolenic acid
  • linolenate
A fatty acid that is found in plants and involved in the formation of prostaglandins.
  • Molecular weight: 278.44
  • Formula: C18H30O2
  • CLOGP: 6.82
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -6.02
  • ROTB: 13

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:50733 nutraceutical

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.76 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Fatty acid-binding protein, heart Cytosolic other Kd 8.56 CHEMBL
Aromatase Enzyme IC50 4.35 CHEMBL
Prostaglandin G/H synthase 1 Enzyme Ki 5.40 CHEMBL
Peroxisome proliferator-activated receptor gamma Nuclear hormone receptor Kd 5.70 CHEMBL
Peroxisome proliferator-activated receptor alpha Nuclear hormone receptor Kd 8.10 CHEMBL
Peroxisome proliferator-activated receptor delta Nuclear hormone receptor IC50 4.80 CHEMBL
Tissue factor Membrane receptor IC50 4.52 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 4.92 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.03 CHEMBL

External reference:

IDSource
4020239 VUID
N0000148143 NUI
C0125903 UMLSCUI
0RBV727H71 UNII
CHEMBL8739 ChEMBL_ID
DB00132 DRUGBANK_ID
LNL PDB_CHEM_ID
CHEBI:27432 CHEBI
D017962 MESH_DESCRIPTOR_UI
5280934 PUBCHEM_CID
81868000 SNOMEDCT_US
009723 NDDF
52071 RXNORM
4020239 VANDF

Pharmaceutical products:

None