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N-Acetylglucosamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4615 | 7512-17-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The N-acetyl derivative of glucosamine.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -1.577 | Moderate | 0.70 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 1.824 | Moderate | 0.70 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 0.671 | 10^-6 cm/s | Moderate | 0.70 |
| dh-clint | Dog hepatocyte intrinsic clearance | 1.159 | uL/min/10^6 cells | Moderate | 0.70 |
| dppb | Dog plasma protein binding (% unbound) | 91.120 | % | Moderate | 0.70 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 84.930 | % | Moderate | 0.70 |
| herg | hERG pIC50 | 3.893 | pIC50 | Moderate | 0.70 |
| hh-clint | Human hepatocyte intrinsic clearance | 0.847 | uL/min/10^6 cells | Moderate | 0.70 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.281 | uL/min/mg protein | Moderate | 0.70 |
| hppb | Human plasma protein binding (% unbound) | 83.110 | % | Moderate | 0.70 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.570 | Moderate | 0.70 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 0.236 | Moderate | 0.70 | |
| mppb | Mouse plasma protein binding (% unbound) | 93.990 | Moderate | 0.70 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.515 | Moderate | 0.70 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 95.820 | % | Moderate | 0.70 |
| rh-clint | Rat hepatocyte intrinsic clearance | 1.786 | uL/min/10^6 cells | Moderate | 0.70 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 87.320 | % | Moderate | 0.70 |
| rppb | Rat plasma protein binding (% unbound) | 94.870 | % | Moderate | 0.70 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 918.333 | uM | Moderate | 0.70 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:78366 | EC 2.7.1.1 (hexokinase) inhibitor |
| CHEBI has role | CHEBI:76969 | bacterial metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.98 | acidic |
| pKa2 | 12.41 | acidic |
| pKa3 | 13.01 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Killer cell lectin-like receptor subfamily B member 1A | Membrane receptor | IC50 | 5.70 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000168415 | NUI |
| CHEBI:28009 | CHEBI |
| NAG | PDB_CHEM_ID |
| CHEMBL447878 | ChEMBL_ID |
| DB00141 | DRUGBANK_ID |
| V956696549 | UNII |
| 1362871 | RXNORM |
| NOCODE | MMSL |
| 015478 | NDDF |
| C0001056 | UMLSCUI |
| D000117 | MESH_DESCRIPTOR_UI |
| 1738118 | PUBCHEM_CID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ginsamin Beauty | HUMAN OTC DRUG LABEL | 4 | 44738-6001 | GRANULE | 200 mg | ORAL | unapproved drug other | 3 sections |
| Cheon Shim Bo Yun | HUMAN OTC DRUG LABEL | 3 | 51220-4001 | CAPSULE | 263 mg | ORAL | unapproved drug other | 8 sections |
| Powerfulx Ginseng RecoveryCream | HUMAN OTC DRUG LABEL | 3 | 70042-0004 | CREAM | 0.15 g | TOPICAL | unapproved drug other | 7 sections |
| PowerfulX RecoveryCream | HUMAN OTC DRUG LABEL | 2 | 70042-0007 | CREAM | 0.02 g | TOPICAL | unapproved drug other | 7 sections |
| Goodoh EnergyCream | HUMAN OTC DRUG LABEL | 2 | 70042-0016 | CREAM | 1 g | TOPICAL | unapproved drug other | 7 sections |
| IMPLAHeal P.OCream | HUMAN OTC DRUG LABEL | 2 | 72368-0007 | CREAM | 2 g | TOPICAL | unapproved drug other | 7 sections |
| Ultra MassageCream | HUMAN OTC DRUG LABEL | 2 | 81712-0001 | CREAM | 12 g | TOPICAL | unapproved drug other | 8 sections |
| ACTS38 BoswelliaGel | HUMAN OTC DRUG LABEL | 4 | 82967-0001 | GEL | 0.10 g | TOPICAL | unapproved drug other | 7 sections |
| ACTS38 BoswelliaGel (100ml) | HUMAN OTC DRUG LABEL | 4 | 82967-0002 | GEL | 0.10 g | TOPICAL | unapproved drug other | 7 sections |