trypan blue 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4608 | 72-57-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A diazo-naphthalene sulfonate that is widely used as a stain.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 16, 2004 | FDA | DORC |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01KX02 | SENSORY ORGANS OPHTHALMOLOGICALS SURGICAL AIDS Other surgical aids |
| FDA MoA | N0000175533 | Dyes |
| FDA EPC | N0000175536 | Diagnostic Dye |
| MeSH PA | D004396 | Coloring Agents |
| CHEBI has role | CHEBI:37958 | dyes |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.76 | acidic |
| pKa2 | 9.36 | acidic |
| pKa3 | 3.76 | Basic |
| pKa4 | 3.16 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Tyrosine-protein phosphatase non-receptor type 1 | Enzyme | IC50 | 5.41 | CHEMBL | |||||
| Tyrosine-protein phosphatase 1 | Enzyme | IC50 | 5.13 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4024919 | VUID |
| N0000167386 | NUI |
| 2538-83-2 | SECONDARY_CAS_RN |
| 4024919 | VANDF |
| CHEBI:78900 | CHEBI |
| CHEMBL1089641 | ChEMBL_ID |
| CHEMBL1640 | ChEMBL_ID |
| I2ZWO3LS3M | UNII |
| DB09158 | DRUGBANK_ID |
| 10878 | RXNORM |
| 20134 | MMSL |
| 005491 | NDDF |
| 417560000 | SNOMEDCT_US |
| 60441008 | SNOMEDCT_US |
| C0041213 | UMLSCUI |
| D014343 | MESH_DESCRIPTOR_UI |
| 6296 | PUBCHEM_CID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| VISIONBLUE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68803-612 | INJECTION, SOLUTION | 0.30 mg | OPHTHALMIC | NDA | 21 sections |
| VISIONBLUE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68803-612 | INJECTION, SOLUTION | 0.30 mg | OPHTHALMIC | NDA | 21 sections |
| MEMBRANEBLUE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68803-672 | INJECTION, SOLUTION | 0.75 mg | OPHTHALMIC | NDA | 19 sections |