trypan blue 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4608 72-57-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trypan blue free acid
  • trypan blue
  • trypane blue
  • naphthylamine blue
  • congo blue
A diazo-naphthalene sulfonate that is widely used as a stain.
  • Molecular weight: 872.87
  • Formula: C34H28N6O14S4
  • CLOGP: -2.26
  • LIPINSKI: 3
  • HAC: 20
  • HDO: 8
  • TPSA: 359.42
  • ALOGS: -4.86
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class AAK1,ACVR1B,ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AURKB,AURKC,AXL,BLK,BMX,BRAF,BTK,CAMK2A,CAMK2B,CAMK2D,CDK1,CDK16,CDK19,CDK2,CDK4,CDK5,CDK9,CHUK,CLK4,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,FGFR1,FGFR4,FLT1,FLT3,FLT4,GRK2,GRK3,GSK3A,GSK3B,IGF1R,IKBKB,INSR,IRAK1,ITK,JAK1,JAK2,JAK3,KDR,KIT,LCK,LYN,MAP2K1,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP3K8,MAP4K1,MAP4K2,MAP4K3,MAP4K5,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MELK,MET,MTOR,NTRK1,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PIM3,PRKAA1,PRKCD,PRKCZ,PRKDC,PTK2,SGK1,SIK2,SIK3,SRC,STK10,STK33,SYK,TEK,TGFBR1,TNIK,TTK,UHMK1,ULK1,ULK2,ZAP70 120
kinase-selectivity-class ACVR2A,ACVR2B,AURKA,AURKB,AURKC,AXL,BMX,BRAF,CAMK2D,CDK16,CDK4,CDK9,DDR1,DYRK1B,DYRK3,EIF2AK3,EPHB4,ERBB2,FGFR1,GRK2,GSK3B,HIPK2,IKBKB,IRAK3,JAK2,MAP2K3,MAP2K6,MAP3K14,MAP3K2,MAP3K7,MAPK1,MAPK12,MAPK14,MAPK7,MAPK8,MTOR,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PRKCZ,PRKDC,SIK2,SRC,STK10,STK33,SYK,TEK,TGFBR1,TTK,UHMK1,ULK1,ULK2,ZAP70 55
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Dec. 16, 2004 FDA DORC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01KX02 SENSORY ORGANS
OPHTHALMOLOGICALS
SURGICAL AIDS
Other surgical aids
FDA MoA N0000175533 Dyes
FDA EPC N0000175536 Diagnostic Dye
MeSH PA D004396 Coloring Agents
CHEBI has role CHEBI:50903 carcinogenic agent
CHEBI has role CHEBI:51217 fluorochrome
CHEBI has role CHEBI:77178 histological dye

Related Drugs by ATC class:

S01KX Other surgical aids 1 drug
chymotrypsin

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.76 acidic
pKa2 9.36 acidic
pKa3 3.76 Basic
pKa4 3.16 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tyrosine-protein phosphatase non-receptor type 1 Enzyme IC50 5.41 CHEMBL
Tyrosine-protein phosphatase 1 Enzyme IC50 5.13 CHEMBL

External reference:

IDSource
4024919 VUID
N0000167386 NUI
2538-83-2 SECONDARY_CAS_RN
4024919 VANDF
CHEMBL1640 ChEMBL_ID
CHEMBL1089641 ChEMBL_ID
I2ZWO3LS3M UNII
DB09158 DRUGBANK_ID
10878 RXNORM
20134 MMSL
005491 NDDF
417560000 SNOMEDCT_US
60441008 SNOMEDCT_US
C0041213 UMLSCUI
D014343 MESH_DESCRIPTOR_UI
CHEBI:78900 CHEBI
6296 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VISIONBLUE HUMAN PRESCRIPTION DRUG LABEL 1 68803-612 INJECTION, SOLUTION 0.30 mg OPHTHALMIC NDA 21 sections
MEMBRANEBLUE HUMAN PRESCRIPTION DRUG LABEL 1 68803-672 INJECTION, SOLUTION 0.75 mg OPHTHALMIC NDA 19 sections