xylitol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4604 87-99-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • xylitol
A five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
  • Molecular weight: 152.15
  • Formula: C5H12O5
  • CLOGP: -1.88
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 5
  • TPSA: 101.15
  • ALOGS: 0.64
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -2.492 High 0.83
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.132 High 0.83
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.581 10^-6 cm/s High 0.83
dh-clint Dog hepatocyte intrinsic clearance 0.582 uL/min/10^6 cells High 0.83
dppb Dog plasma protein binding (% unbound) 91.890 % High 0.83
fcs-ppb Fetal calf serum protein binding (% unbound) 96.890 % High 0.83
herg hERG pIC50 3.565 pIC50 High 0.83
hh-clint Human hepatocyte intrinsic clearance 0.839 uL/min/10^6 cells High 0.83
hlm-clint Human liver microsomal intrinsic clearance 3.105 uL/min/mg protein High 0.83
hppb Human plasma protein binding (% unbound) 82.620 % High 0.83
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK2,PDK2,PDK4,PIK3CB,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK 30
kinase-selectivity-class ACVRL1,AURKB,AXL,BMX,BRAF,CDK1,CDK16,CDK2,CDK3,CDK4,CDK6,CDK7,CDK8,CDK9,CHUK,DYRK1A,EPHB4,IGF1R,INSR,IRAK1,IRAK3,IRAK4,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,PAK4,PDK1,PIK3CB,PIK3CD,PIK3CG,PRKDC,SYK,TEK,TGFBR1,TYRO3,ZAP70 38
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.228 High 0.83
mh-clint Mouse hepatocyte intrinsic clearance 0.175 High 0.83
mppb Mouse plasma protein binding (% unbound) 97.790 High 0.83
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.253 High 0.83
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 96.590 % High 0.83
rh-clint Rat hepatocyte intrinsic clearance 1.227 uL/min/10^6 cells High 0.83
rh-fuinc Rat hepatocyte fraction unbound in incubation 96.750 % High 0.83
rppb Rat plasma protein binding (% unbound) 97.200 % High 0.83
solubility-dd Solubility at pH 7.4 in DMSO 977.237 uM High 0.83

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D005421 Flavoring Agents
MeSH PA D005503 Food Additives
MeSH PA D013549 Sweetening Agents
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:50505 sweetening agent
CHEBI has role CHEBI:50904 allergen
CHEBI has role CHEBI:59174 hapten
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75772 <em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:84735 algal metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Prevention of dental caries indication 426482000
Gingivitis off-label use 66383009 DOID:3087
Dental Plaque Prevention off-label use
Dental fluorosis contraindication 30265004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.28 acidic
pKa2 13.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D00061 KEGG_DRUG
4020499 VUID
N0000148228 NUI
4020499 VANDF
CHEBI:17151 CHEBI
XYL PDB_CHEM_ID
CHEMBL96783 ChEMBL_ID
DB11195 DRUGBANK_ID
VCQ006KQ1E UNII
11377 RXNORM
26100 MMSL
NOCODE MMSL
d07373 MMSL
006331 NDDF
395951005 SNOMEDCT_US
398986008 SNOMEDCT_US
C0043369 UMLSCUI
D014993 MESH_DESCRIPTOR_UI
6912 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Noble G Plus HUMAN OTC DRUG LABEL 1 60319-3001 PASTE, DENTIFRICE 0.70 g DENTAL unapproved drug other 8 sections
Noble 1 Plus HUMAN OTC DRUG LABEL 1 60319-4001 POWDER, DENTIFRICE 0.70 g DENTAL unapproved drug other 9 sections
YUMAKI ORIGINAL MINT TOOTH HUMAN OTC DRUG LABEL 7 71746-010 PASTE, DENTIFRICE 0.10 g TOPICAL unapproved drug other 8 sections
ADEA GARGLE HUMAN OTC DRUG LABEL 2 72191-0100 TABLET, CHEWABLE 5 g ORAL unapproved drug other 7 sections
CELRAUM PHEROMONE FRAGRANCE LOVELY PERFUME HUMAN OTC DRUG LABEL 6 75368-040 SHAMPOO 0.02 g TOPICAL unapproved drug other 9 sections
Hoo gargle (Mouthwash) HUMAN OTC DRUG LABEL 1 81840-1001 LIQUID 1 g DENTAL unapproved drug other 7 sections
Hoo gargle (Rooibos Tea Flavor)(Mouthwash) HUMAN OTC DRUG LABEL 1 81840-1003 LIQUID 1 g DENTAL unapproved drug other 7 sections
Hoo gargle (Jasmine Flavor)(Mouthwash) HUMAN OTC DRUG LABEL 1 81840-1022 LIQUID 1 g DENTAL unapproved drug other 7 sections
BOP whiteningtoothpaste HUMAN OTC DRUG LABEL 2 82574-001 GEL 3 g TOPICAL unapproved drug other 8 sections
Kids Oral Care Strawberry Flavor HUMAN OTC DRUG LABEL 2 82711-101 SPRAY 2 mg DENTAL unapproved drug other 10 sections
Kids Oral Care Peach Flavor HUMAN OTC DRUG LABEL 2 82711-102 SPRAY 2 mg DENTAL unapproved drug other 10 sections
Kids Oral Care Vanilla Flavor HUMAN OTC DRUG LABEL 2 82711-103 SPRAY 2 mg DENTAL unapproved drug other 10 sections
Kids Oral Care Grape Flavor HUMAN OTC DRUG LABEL 2 82711-104 SPRAY 2 mg DENTAL unapproved drug other 10 sections
Kids Oral Care Watermelon Flavor HUMAN OTC DRUG LABEL 2 82711-105 SPRAY 2 mg DENTAL unapproved drug other 10 sections
Kids Oral Care Flavor Free HUMAN OTC DRUG LABEL 2 82711-106 SPRAY 2 mg DENTAL unapproved drug other 10 sections
GZE Mouthwash HUMAN OTC DRUG LABEL 3 83566-035 LIQUID 2 g TOPICAL OTC Monograph Drug 11 sections
Dry Mouth MoisturizingSpray HUMAN OTC DRUG LABEL 2 84025-097 SPRAY 3 mg CUTANEOUS OTC Monograph Drug 4 sections
Dry MonthSpray HUMAN OTC DRUG LABEL 2 84025-159 SPRAY 3 mg DENTAL OTC Monograph Drug 5 sections
Dry Month MoisturizingSpray HUMAN OTC DRUG LABEL 2 84025-160 SPRAY 3 mg DENTAL OTC Monograph Drug 5 sections
hydrating mouthspray HUMAN OTC DRUG LABEL 2 84025-251 LIQUID 3 mg CUTANEOUS OTC Monograph Drug 5 sections
Peppermint mouthspray HUMAN OTC DRUG LABEL 2 84025-257 SPRAY 3 mg CUTANEOUS OTC Monograph Drug 5 sections
dry mouth moisturizingspray HUMAN OTC DRUG LABEL 2 84025-267 LIQUID 3 mg CUTANEOUS OTC Monograph Drug 5 sections
Teeth whitening powder HUMAN OTC DRUG LABEL 2 84025-281 POWDER 5 mg CUTANEOUS OTC Monograph Drug 5 sections
PurpleToothpaste HUMAN OTC DRUG LABEL 1 84117-036 LOTION 20 mg ORAL OTC Monograph Drug 7 sections
ORALHOE Probiotic Brightening HUMAN OTC DRUG LABEL 4 84660-036 CREAM 30 g TOPICAL OTC Monograph Drug 8 sections
Teeth Cleaning HUMAN OTC DRUG LABEL 2 84732-026 TABLET, CHEWABLE 1 mg DENTAL OTC Monograph Drug 9 sections
Teeth Cleaning HUMAN OTC DRUG LABEL 2 84732-051 TABLET, CHEWABLE 1 mg DENTAL OTC Monograph Drug 9 sections