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taurine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4486 | 107-35-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A conditionally essential nutrient, important during mammalian development. It is present in milk but is isolated mostly from ox bile and strongly conjugates bile acids.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK1,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 56 | |||
| kinase-selectivity-class | AXL,BRAF,CAMK2B,CAMK2D,CDK1,CDK4,CDK6,CDK7,CDK9,CHEK1,CHUK,DDR1,DYRK1A,DYRK1B,EPHB4,GRK2,HASPIN,IRAK1,IRAK4,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK7,PAK4,PRKCD,SIK2,SIK3,STK33,SYK,TEK,ULK2 | 32 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Feb. 21, 2019 | PMDA | TAISHO PHARMACEUTICAL CO., LTD. | |
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Retinogram abnormal | 28.41 | 25.65 | 4 | 615 | 174 | 90627654 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Retinogram abnormal | 39.54 | 25.80 | 6 | 867 | 380 | 110588046 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:22586 | antioxidant |
| CHEBI has role | CHEBI:33284 | nutrient |
| CHEBI has role | CHEBI:35476 | antipsychotic agent |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35674 | antihypertensive agent |
| CHEBI has role | CHEBI:35705 | immunosuppressive agent |
| CHEBI has role | CHEBI:48578 | radical scavenger |
| CHEBI has role | CHEBI:64589 | glycine receptor agonist |
| CHEBI has role | CHEBI:75771 | mouse metabolite |
| CHEBI has role | CHEBI:75772 | <em>Saccharomyces cerevisiae </em> metabolite |
| CHEBI has role | CHEBI:76971 | <em>Escherichia coli</em> metabolite |
| CHEBI has role | CHEBI:77746 | human metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Stroke-like episodes in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) | indication | 39925003 | DOID:3687 |
| Nutritional support | indication | 278906000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 0.75 | acidic |
| pKa2 | 9.3 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D00047 | KEGG_DRUG |
| 4018683 | VUID |
| N0000146994 | NUI |
| 4018683 | VANDF |
| CHEBI:15891 | CHEBI |
| TAU | PDB_CHEM_ID |
| CHEMBL239243 | ChEMBL_ID |
| 2379 | IUPHAR_LIGAND_ID |
| 6171 | INN_ID |
| DB01956 | DRUGBANK_ID |
| 1EQV5MLY3D | UNII |
| 10337 | RXNORM |
| 15457 | MMSL |
| 187442 | MMSL |
| d07830 | MMSL |
| 009160 | NDDF |
| 10944007 | SNOMEDCT_US |
| 419158001 | SNOMEDCT_US |
| C0039350 | UMLSCUI |
| D013654 | MESH_DESCRIPTOR_UI |
| 1123 | PUBCHEM_CID |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| TrophAmine | HUMAN PRESCRIPTION DRUG LABEL | 20 | 0264-1933 | SOLUTION | 0.03 g | INTRAVENOUS | NDA | 23 sections |
| Premasol - sulfite-free (Amino Acid) | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0338-1130 | INJECTION, SOLUTION | 25 mg | INTRAVENOUS | ANDA | 15 sections |
| Premasol - sulfite-free (Amino Acid) | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0338-1131 | INJECTION, SOLUTION | 15 mg | INTRAVENOUS | ANDA | 15 sections |
| Aminosyn-PF | HUMAN PRESCRIPTION DRUG LABEL | 18 | 0990-4178 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | NDA | 13 sections |
| Aminosyn-PF | HUMAN PRESCRIPTION DRUG LABEL | 18 | 0990-4178 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | NDA | 13 sections |
| Aminosyn-PF | HUMAN PRESCRIPTION DRUG LABEL | 18 | 0990-4179 | INJECTION, SOLUTION | 70 mg | INTRAVENOUS | NDA | 14 sections |
| Aminosyn-PF | HUMAN PRESCRIPTION DRUG LABEL | 18 | 0990-4179 | INJECTION, SOLUTION | 70 mg | INTRAVENOUS | NDA | 14 sections |
| Ginsamin Energy | HUMAN OTC DRUG LABEL | 5 | 44738-7001 | LIQUID | 1000 mg | ORAL | unapproved drug other | 3 sections |
| LINGTEA | HUMAN OTC DRUG LABEL | 1 | 72355-0001 | POWDER | 1 g | ORAL | unapproved drug other | 6 sections |
| GZE Yellow Peeling Oil | HUMAN OTC DRUG LABEL | 3 | 74458-050 | LIQUID | 2 g | TOPICAL | OTC Monograph Drug | 10 sections |
| XIMONTH Presbyopia Vision Herbal Drops | HUMAN OTC DRUG LABEL | 4 | 84660-054 | LIQUID | 1.50 mg | TOPICAL | OTC Monograph Drug | 8 sections |