phosphoric acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4478 7664-38-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phosphoric acid
concise etchant is 37% H3PO4
  • Molecular weight: 97.99
  • Formula: H3O4P
  • CLOGP: -2.17
  • LIPINSKI: None
  • HAC: 4
  • HDO: 3
  • TPSA: 77.76
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT1,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 62
kinase-selectivity-class ACVR2B,ACVRL1,ALK,AURKA,AURKB,AXL,BMX,BRAF,CDK1,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,IRAK1,IRAK3,KDR,MAP2K6,MAP3K21,MAPK7,PIK3CD,PIK3CG,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 31
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Sept. 24, 1971 FDA B BRAUN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Creatinine renal clearance decreased 180.57 17.48 64 6840 18835 90602708
Sedation complication 171.89 17.48 60 6844 16884 90604659
Blood calcium decreased 158.16 17.48 66 6838 30116 90591427
Orthostatic hypotension 149.78 17.48 70 6834 41757 90579786
Balance disorder 147.84 17.48 92 6812 96988 90524555
Constipation 117.99 17.48 125 6779 280270 90341273
Sedation 117.19 17.48 62 6842 48109 90573434
Cognitive disorder 116.41 17.48 70 6834 69337 90552206
Depressed level of consciousness 113.34 17.48 70 6834 72714 90548829
Skin candida 111.42 17.48 26 6878 1715 90619828
Renal function test abnormal 74.95 17.48 26 6878 7165 90614378
Creatinine renal clearance increased 72.33 17.48 21 6883 3260 90618283
Multiple drug therapy 56.68 17.48 21 6883 6988 90614555
Neutropenic sepsis 54.70 17.48 27 6877 18103 90603440
Hypotension 48.57 17.48 88 6816 325309 90296234
Mobility decreased 45.54 17.48 74 6830 250660 90370883
Nervous system disorder 42.01 17.48 24 6880 21569 90599974
Dehydration 41.74 17.48 62 6842 194385 90427158
Fall 41.35 17.48 104 6800 481706 90139837
Hypomagnesaemia 37.81 17.48 27 6877 35561 90585982
Mouth ulceration 37.21 17.48 28 6876 39946 90581597
Dysphagia 35.08 17.48 43 6861 112235 90509308
Candida infection 34.27 17.48 25 6879 34032 90587511
Mucosal inflammation 34.04 17.48 31 6873 57594 90563949
Gait disturbance 33.31 17.48 66 6838 260430 90361113
Oesophagitis 30.45 17.48 18 6886 17231 90604312
Productive cough 29.90 17.48 33 6871 77030 90544513
Hypokalaemia 28.39 17.48 42 6862 131074 90490469
Toxicity to various agents 24.49 17.48 62 6842 287784 90333759
Dyspnoea 24.03 17.48 131 6773 880824 89740719
Neutrophil count decreased 23.31 17.48 28 6876 71504 90550039
Bladder disorder 21.02 17.48 12 6892 10760 90610783
Drug abuse 20.19 17.48 28 6876 82319 90539224
Anaemia 19.39 17.48 65 6839 352737 90268806
Maternal exposure during pregnancy 17.83 17.48 3 6901 360060 90261483

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Periarthritis 27.56 18.97 8 2931 1372 42617024
Dehydration 26.29 18.97 40 2899 141727 42476669
Testicular haemorrhage 23.23 18.97 5 2934 252 42618144
Dysphagia 20.25 18.97 25 2914 72694 42545702
Radiation oesophagitis 20.04 18.97 5 2934 483 42617913

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Creatinine renal clearance decreased 193.23 17.37 69 7967 21746 110559517
Sedation complication 180.40 17.37 64 7972 19791 110561472
Blood calcium decreased 169.90 17.37 72 7964 35773 110545490
Balance disorder 160.84 17.37 102 7934 116458 110464805
Orthostatic hypotension 133.32 17.37 74 7962 66175 110515088
Constipation 117.46 17.37 137 7899 357649 110223614
Cognitive disorder 116.72 17.37 75 7961 87436 110493827
Sedation 106.19 17.37 65 7971 69618 110511645
Skin candida 100.10 17.37 25 8011 2303 110578960
Depressed level of consciousness 95.39 17.37 73 7963 112205 110469058
Creatinine renal clearance increased 71.24 17.37 21 8015 3604 110577659
Renal function test abnormal 70.60 17.37 26 8010 8920 110572343
Mobility decreased 57.17 17.37 78 7958 237344 110343919
Multiple drug therapy 54.90 17.37 21 8015 7993 110573270
Fall 50.20 17.37 125 7911 603357 109977906
Neutropenic sepsis 42.56 17.37 27 8009 30719 110550544
Dehydration 42.17 17.37 74 7962 279437 110301826
Hypotension 40.91 17.37 106 7930 523743 110057520
Nervous system disorder 34.57 17.37 24 8012 31697 110549566
Dysphagia 31.81 17.37 47 7989 153553 110427710
Candida infection 31.77 17.37 27 8009 47982 110533281
Mouth ulceration 31.71 17.37 27 8009 48111 110533152
Pain 27.26 17.37 139 7897 954816 109626447
Hypomagnesaemia 26.48 17.37 27 8009 60343 110520920
Therapeutic reaction time decreased 26.31 17.37 11 8025 5268 110575995
Bladder disorder 23.91 17.37 13 8023 11124 110570139
Gait disturbance 23.44 17.37 58 7978 278150 110303113
Testicular haemorrhage 23.05 17.37 5 8031 248 110581015
Mucosal inflammation 22.21 17.37 31 8005 96110 110485153
Productive cough 19.50 17.37 32 8004 114273 110466990

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D003764 Dental Materials
CHEBI has role CHEBI:33287 fertilizer
CHEBI has role CHEBI:46787 solvent
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:84735 algal metabolite
CHEBI has role CHEBI:228364 NMR chemical shift reference compound

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Nutritional support indication 278906000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.0 acidic
pKa2 6.06 acidic
pKa3 11.11 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D05467 KEGG_DRUG
4018718 VUID
N0000178952 NUI
4018718 VANDF
CHEBI:26078 CHEBI
CHEMBL1187 ChEMBL_ID
C030242 MESH_SUPPLEMENTAL_RECORD_UI
DB09394 DRUGBANK_ID
E4GA8884NN UNII
8259 RXNORM
NOCODE MMSL
006128 NDDF
C0031700 UMLSCUI
2HP PDB_CHEM_ID
IPS PDB_CHEM_ID
PI PDB_CHEM_ID
PO4 PDB_CHEM_ID
1004 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Walgreen Anti Nausea Cherry Flavor HUMAN OTC DRUG LABEL 3 0363-7080 SOLUTION 21.50 mg ORAL unapproved drug other 13 sections
WALGREENCHILDREN ANTI NAUSEA HUMAN OTC DRUG LABEL 3 0363-7081 SOLUTION 21.50 mg ORAL Unapproved drug other 13 sections
Anti Nausea HUMAN OTC DRUG LABEL 3 0536-1302 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Anti Nausea HUMAN OTC DRUG LABEL 3 0536-1302 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Select Brand Anti-Nausea HUMAN OTC DRUG LABEL 2 15127-291 SOLUTION 21.50 mg ORAL unapproved drug other 11 sections
Kroger Anti Nausea Cherry Flavor HUMAN OTC DRUG LABEL 3 30142-708 LIQUID 21.50 mg ORAL unapproved drug other 13 sections
Anti Nausea Liquid HUMAN OTC DRUG LABEL 3 36800-708 SOLUTION 21.50 mg ORAL Unapproved drug other 13 sections
Anti Nausea Liquid HUMAN OTC DRUG LABEL 3 36800-708 SOLUTION 21.50 mg ORAL Unapproved drug other 13 sections
HEB Anti Nausea HUMAN OTC DRUG LABEL 3 37808-883 LIQUID 21.50 mg ORAL unapproved drug other 13 sections
Meijer Anti Nausea HUMAN OTC DRUG LABEL 3 41250-495 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Meijer Anti Nausea HUMAN OTC DRUG LABEL 3 41250-495 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Good Neighbor Anti NauseaCherry Flavor HUMAN OTC DRUG LABEL 3 46122-729 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
PASSIFLORA PLEX HUMAN OTC DRUG LABEL 8 52503-1322 LIQUID 14 [hp_X] SUBLINGUAL unapproved drug other 13 sections
Discount Drug Mart nausea control Cherry Flavor HUMAN OTC DRUG LABEL 3 53943-708 SOLUTION 21.50 mg ORAL unapproved drug other 13 sections
1 Detoxification HUMAN OTC DRUG LABEL 81 55146-011 LIQUID 30 [hp_C] ORAL unapproved homeopathic 9 sections
Homeopathic Stress Mints HUMAN OTC DRUG LABEL 9 57556-004 LOZENGE 12 [hp_X] ORAL unapproved drug other 6 sections
Homeopathic Stress Mints HUMAN OTC DRUG LABEL 9 57556-004 LOZENGE 12 [hp_X] ORAL unapproved drug other 6 sections
Anti Nausea Liquid Cherry Flavor HUMAN OTC DRUG LABEL 3 63868-704 SOLUTION 21.50 mg ORAL unapproved drug other 13 sections
Best Choice Anti NauseaCherry Flavor HUMAN OTC DRUG LABEL 3 63941-708 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Emetrol Cherry HUMAN OTC DRUG LABEL 3 65197-201 SOLUTION 21.50 mg ORAL unapproved drug other 13 sections
Emetrol Children Mixed Berry HUMAN OTC DRUG LABEL 3 65197-202 SOLUTION 21.50 mg ORAL unapproved drug other 14 sections
Premier Value Nausea ControlCherry Flavor HUMAN OTC DRUG LABEL 3 68016-807 SOLUTION 21.50 mg ORAL Unapproved drug other 13 sections
Emetrol Cherry HUMAN OTC DRUG LABEL 2 68788-9801 SOLUTION 21.50 mg ORAL Unapproved drug other 13 sections
CVS Anti Nausea Cherry Flavor HUMAN OTC DRUG LABEL 3 69842-708 LIQUID 21.50 mg ORAL unapproved drug other 13 sections
Anti Nausea HUMAN OTC DRUG LABEL 3 70000-0052 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Anti Nausea HUMAN OTC DRUG LABEL 3 70000-0052 LIQUID 21.50 mg ORAL Unapproved drug other 13 sections
Phosphoricum Acidum HUMAN OTC DRUG LABEL 1 79718-1012 LIQUID 30 [hp_C] ORAL unapproved homeopathic 8 sections
QUALITY CHOICE Anti-Nausea HUMAN OTC DRUG LABEL 3 83324-217 SOLUTION 21.50 mg ORAL unapproved drug other 13 sections