manganese sulfate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4461 7785-87-7

Description:

MoleculeDescription

Synonyms:

  • manganese sulfate
  • Molecular weight: 150.99
  • Formula: MnO4S
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA: 80.26
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1204.25 9.67 3657 275700 236558 46170147
Pemphigus 975.70 9.67 1277 278080 43997 46362708
Systemic lupus erythematosus 840.80 9.67 1446 277911 63734 46342971
Completed suicide 648.34 9.67 62 279295 145858 46260847
Glossodynia 646.50 9.67 1040 278317 43333 46363372
Hand deformity 484.08 9.67 796 278561 33778 46372927
Maternal exposure during pregnancy 481.17 9.67 1528 277829 101021 46305684
Arthropathy 398.99 9.67 1264 278093 83436 46323269
Alopecia 397.05 9.67 1972 277385 160442 46246263
Toxicity to various agents 372.61 9.67 431 278926 211335 46195370
Abdominal discomfort 366.30 9.67 1831 277526 149334 46257371
Infusion related reaction 364.92 9.67 1382 277975 99826 46306879
Joint swelling 361.26 9.67 1952 277405 164121 46242584
Pain 353.46 9.67 4378 274979 472570 45934135
Arthralgia 326.37 9.67 3473 275884 361130 46045575
Death 316.12 9.67 995 278362 334553 46072152
Wound 310.24 9.67 748 278609 42054 46364651
Exposure during pregnancy 293.23 9.67 1354 278003 106858 46299847
Drug abuse 286.65 9.67 25 279332 63383 46343322
Synovitis 278.00 9.67 901 278456 60174 46346531
Contraindicated product administered 251.27 9.67 1046 278311 78901 46327804
Intentional overdose 248.97 9.67 44 279313 64900 46341805
Anti-cyclic citrullinated peptide antibody positive 235.19 9.67 416 278941 18729 46387976
Drug interaction 226.85 9.67 554 278803 202540 46204165
Pericarditis 210.98 9.67 452 278905 23475 46383230
Swelling 205.99 9.67 1363 277994 123148 46283557
Rheumatoid factor positive 203.29 9.67 406 278951 20055 46386650
Nasopharyngitis 198.54 9.67 1588 277769 152410 46254295
Hip arthroplasty 180.67 9.67 360 278997 17752 46388953
Overdose 178.64 9.67 208 279149 101771 46304934
Red blood cell sedimentation rate abnormal 165.61 9.67 295 279062 13354 46393351
Product use issue 164.99 9.67 1050 278307 93594 46313111
Suicide attempt 162.25 9.67 63 279294 54973 46351732
C-reactive protein abnormal 160.86 9.67 378 278979 20892 46385813
Knee arthroplasty 160.22 9.67 403 278954 23262 46383443
Musculoskeletal stiffness 154.97 9.67 1061 278296 96932 46309773
Febrile neutropenia 152.17 9.67 206 279151 94421 46312284
Drug hypersensitivity 152.06 9.67 847 278510 242978 46163727
Cardiac arrest 150.27 9.67 192 279165 90207 46316498
Injection site erythema 145.71 9.67 851 278506 73576 46333129
Discomfort 138.32 9.67 600 278757 46070 46360635
Acute kidney injury 137.08 9.67 838 278519 235017 46171688
Sickle cell anaemia with crisis 135.03 9.67 142 279215 3850 46402855
Injection site pain 133.14 9.67 1096 278261 106056 46300649
Pregnancy 129.47 9.67 407 278950 26730 46379975
Device expulsion 113.89 9.67 15 279342 27527 46379178
Injection site pruritus 112.49 9.67 504 278853 39239 46367466
Drug ineffective 109.64 9.67 5027 274330 672811 45733894
Therapeutic product effect decreased 108.07 9.67 855 278502 81746 46324959
Abortion spontaneous 107.81 9.67 532 278825 43114 46363591
Depressed level of consciousness 107.05 9.67 77 279280 47492 46359213
Arthritis 105.97 9.67 809 278548 76507 46330198
Psoriatic arthropathy 103.46 9.67 462 278895 35917 46370788
Malignant neoplasm progression 101.69 9.67 144 279213 64782 46341923
Blood pressure fluctuation 101.61 9.67 406 278951 30042 46376663
Bradycardia 99 9.67 152 279205 66146 46340559
Lactic acidosis 96.38 9.67 41 279316 33868 46372837
Injection site swelling 94.98 9.67 485 278872 39842 46366863
Injection site reaction 94.19 9.67 548 278809 47301 46359404
Hyponatraemia 94.01 9.67 302 279055 101030 46305675
Respiratory arrest 91.26 9.67 44 279313 33772 46372933
Cardiac failure 89.18 9.67 218 279139 79730 46326975
Duodenal ulcer perforation 86.00 9.67 170 279187 8332 46398373
Osteoarthritis 85.53 9.67 650 278707 61375 46345330
Disease progression 85.46 9.67 271 279086 91029 46315676
Anxiety 83.89 9.67 691 278666 181266 46225439
Confusional state 83.73 9.67 586 278771 159306 46247399
Electrocardiogram QT prolonged 83.22 9.67 111 279246 51214 46355491
Helicobacter infection 81.68 9.67 202 279155 11534 46395171
Basal cell carcinoma 80.63 9.67 288 279069 20199 46386506
Treatment failure 79.20 9.67 879 278478 92208 46314497
Drug reaction with eosinophilia and systemic symptoms 75.92 9.67 41 279316 29507 46377198
Joint effusion 75.74 9.67 199 279158 11796 46394909
Dyspnoea 75.57 9.67 2431 276926 513117 45893588
Caesarean section 72.84 9.67 242 279115 16361 46390344
Renal failure 72.10 9.67 392 278965 113202 46293503
Disability assessment scale score increased 71.26 9.67 77 279280 2155 46404550
Agitation 70.94 9.67 140 279217 55275 46351430
Sopor 70.61 9.67 16 279341 19812 46386893
Product quality issue 69.92 9.67 66 279291 35582 46371123
Tremor 69.64 9.67 406 278951 115233 46291472
Intentional self-injury 69.03 9.67 29 279328 24137 46382568
Neutropenia 68.66 9.67 538 278819 142666 46264039
Rhabdomyolysis 68.59 9.67 90 279267 41819 46364886
Cardio-respiratory arrest 68.54 9.67 161 279196 59708 46346997
Lower respiratory tract infection 67.03 9.67 561 278796 54528 46352177
Multiple sclerosis relapse 66.38 9.67 93 279264 42032 46364673
Drug withdrawal syndrome 66.08 9.67 41 279316 27343 46379362
Sinusitis 65.86 9.67 1117 278240 128651 46278054
Constipation 64.86 9.67 697 278660 173400 46233305
Hepatic enzyme increased 63.60 9.67 759 278598 81028 46325677
Dizziness 62.82 9.67 1554 277803 338860 46067845
Impaired healing 61.72 9.67 404 278953 36339 46370366
Joint laxity 61.20 9.67 69 279288 2027 46404678
Somnolence 61 9.67 620 278737 155901 46250804
Red blood cell sedimentation rate increased 60.85 9.67 285 279072 22604 46384101
Injection site bruising 60.58 9.67 393 278964 35243 46371462
Psoriasis 60.04 9.67 727 278630 77877 46328828
Live birth 59.82 9.67 166 279191 10164 46396541
Asthma 59.70 9.67 313 279044 91229 46315476
Localised infection 59.39 9.67 291 279066 23510 46383195
Nausea 58.53 9.67 3444 275913 684010 45722695
Hypotension 58.20 9.67 1010 278347 231579 46175126
Blood pressure diastolic abnormal 57.90 9.67 121 279236 6173 46400532
Sedation 57.11 9.67 33 279324 22877 46383828
Osteoporosis 56.78 9.67 427 278930 40181 46366524
Drug dependence 56.66 9.67 24 279333 19877 46386828
Premature labour 55.30 9.67 171 279186 11128 46395577
Loss of personal independence in daily activities 54.72 9.67 553 278804 56630 46350075
Rheumatoid nodule 53.28 9.67 146 279211 8874 46397831
Pulmonary arterial hypertension 53.24 9.67 46 279311 25882 46380823
Insomnia 53.03 9.67 682 278675 164242 46242463
Injection site rash 52.06 9.67 210 279147 15603 46391102
Maternal drugs affecting foetus 51.84 9.67 107 279250 5411 46401294
Neoplasm progression 51.63 9.67 50 279307 26633 46380072
Foetal exposure during pregnancy 51.60 9.67 338 279019 30409 46376296
Delirium 51.23 9.67 90 279267 37138 46369567
Oropharyngeal pain 51.11 9.67 673 278684 73495 46333210
Neck deformity 50.70 9.67 59 279298 1795 46404910
Pre-eclampsia 49.84 9.67 132 279225 7862 46398843
Juvenile idiopathic arthritis 49.73 9.67 89 279268 4043 46402662
Hypoglycaemia 49.67 9.67 163 279194 54186 46352519
Tachycardia 49.27 9.67 371 278986 99251 46307454
Palmar-plantar erythrodysaesthesia syndrome 48.82 9.67 31 279326 20420 46386285
Coma 48.63 9.67 182 279175 58167 46348538
Hepatic failure 48.55 9.67 78 279279 33338 46373367
Diarrhoea 47.97 9.67 2801 276556 556801 45849904
Asthenia 47.80 9.67 1457 277900 309618 46097087
Intentional product misuse 47.59 9.67 135 279222 46993 46359712
Serotonin syndrome 47.31 9.67 45 279312 24175 46382530
Gestational diabetes 46.84 9.67 121 279236 7098 46399607
Encephalopathy 46.40 9.67 81 279276 33508 46373197
Herpes zoster 45.99 9.67 614 278743 67258 46339447
No adverse event 45.98 9.67 84 279273 34147 46372558
Vomiting 45.58 9.67 2230 277127 450564 45956141
Blood pressure systolic abnormal 44.96 9.67 101 279256 5416 46401289
Therapeutic response decreased 44.57 9.67 424 278933 42721 46363984
Tuberculosis 44.48 9.67 149 279208 10116 46396589
Drug intolerance 44.31 9.67 1173 278184 145876 46260829
Condition aggravated 44.04 9.67 1839 277518 243213 46163492
Pain in extremity 43.97 9.67 1930 277427 256750 46149955
Foot deformity 43.92 9.67 196 279161 15229 46391476
Cholestasis 43.75 9.67 58 279299 26835 46379870
Hyperglycaemia 43.69 9.67 90 279267 34981 46371724
Hyperhidrosis 43.49 9.67 334 279023 88974 46317731
Poisoning 42.95 9.67 15 279342 13979 46392726
Diabetic ketoacidosis 42.93 9.67 28 279329 18182 46388523
Neuropathy peripheral 42.83 9.67 343 279014 90550 46316155
Bone erosion 42.64 9.67 139 279218 9304 46397401
Renal impairment 42.19 9.67 266 279091 74106 46332599
Cytomegalovirus infection 41.30 9.67 29 279328 18115 46388590
Musculoskeletal pain 40.55 9.67 617 278740 69511 46337194
Myalgia 40.29 9.67 507 278850 122581 46284124
Hallucination 40.21 9.67 158 279199 49793 46356912
Hepatocellular injury 40.05 9.67 72 279285 29450 46377255
Metabolic acidosis 39.96 9.67 110 279247 38670 46368035
Infective pulmonary exacerbation of cystic fibrosis 39.95 9.67 8 279349 10799 46395906
Fatigue 39.95 9.67 4191 275166 604506 45802199
Hepatic function abnormal 39.84 9.67 92 279265 34329 46372376
Nodule 39.80 9.67 192 279165 15413 46391292
Altered state of consciousness 39.38 9.67 49 279308 23299 46383406
Blood pressure systolic increased 39.28 9.67 301 279056 28486 46378219
Ventricular septal defect 38.81 9.67 79 279278 3955 46402750
Blood pressure diastolic decreased 38.54 9.67 178 279179 14033 46392672
Disturbance in attention 38.46 9.67 82 279275 31478 46375227
Influenza 38.43 9.67 749 278608 88521 46318184
Syncope 38.42 9.67 421 278936 104382 46302323
Hypoxia 37.99 9.67 170 279187 51668 46355037
Limb deformity 37.99 9.67 73 279284 3503 46403202
Small for dates baby 37.12 9.67 73 279284 3564 46403141
Malignant melanoma 37.01 9.67 140 279217 10094 46396611
Plasma cell myeloma 36.88 9.67 139 279218 44339 46362366
Oral herpes 36.81 9.67 220 279137 19170 46387535
Drug resistance 36.66 9.67 30 279327 17338 46389367
Premature delivery 36.66 9.67 242 279115 21827 46384878
Product use in unapproved indication 36.64 9.67 354 279003 89919 46316786
Emotional distress 36.42 9.67 81 279276 30626 46376079
Inflammation 36.29 9.67 449 278908 48332 46358373
Fibromyalgia 36.02 9.67 355 279002 36108 46370597
Femur fracture 35.97 9.67 359 278998 36638 46370067
Cardiac failure congestive 35.89 9.67 363 278994 91387 46315318
Osteonecrosis of jaw 35.89 9.67 97 279260 34305 46372400
Restlessness 35.76 9.67 61 279296 25463 46381242
Grip strength decreased 35.60 9.67 123 279234 8483 46398222
Urticaria 35.51 9.67 494 278863 117398 46289307
Respiratory failure 35.51 9.67 379 278978 94437 46312268
Peripheral swelling 35.49 9.67 1216 278141 156855 46249850
Ejection fraction decreased 35.42 9.67 33 279324 17904 46388801
Skin ulcer 35.04 9.67 322 279035 32136 46374569
Bronchitis 35.03 9.67 856 278501 105123 46301582
Hyperkalaemia 34.97 9.67 170 279187 50539 46356166
Heart rate decreased 34.90 9.67 316 279041 31407 46375298
Injection site warmth 34.80 9.67 169 279188 13603 46393102
Mydriasis 34.72 9.67 10 279347 10543 46396162
Shock 34.64 9.67 48 279309 21797 46384908
Arthritis infective 34.52 9.67 87 279270 5026 46401679
Smear cervix abnormal 33.94 9.67 57 279300 2459 46404246
Weight increased 33.66 9.67 1252 278105 163221 46243484
Neck mass 33.49 9.67 66 279291 3227 46403478
Joint stiffness 33.47 9.67 277 279080 26831 46379874
Anaphylactic reaction 33.28 9.67 184 279173 52928 46353777
Enthesopathy 32.93 9.67 81 279276 4609 46402096
Mental status changes 32.92 9.67 117 279240 37971 46368734
Disorientation 32.85 9.67 112 279245 36806 46369899
Multiple organ dysfunction syndrome 32.48 9.67 179 279178 51531 46355174
Decreased appetite 32.20 9.67 898 278459 192938 46213767
Developmental hip dysplasia 32.07 9.67 39 279318 1244 46405461
Joint destruction 31.88 9.67 62 279295 3002 46403703
Hypokalaemia 31.71 9.67 355 279002 87669 46319036
Premature rupture of membranes 31.70 9.67 77 279280 4346 46402359
Blood creatine phosphokinase increased 31.37 9.67 75 279282 27649 46379056
Hypothermia 31.16 9.67 17 279340 12166 46394539
Blood pressure diastolic increased 30.72 9.67 92 279265 5882 46400823
Postoperative wound infection 30.23 9.67 118 279239 8635 46398070
General physical health deterioration 30.11 9.67 499 278858 115270 46291435
Respiratory depression 29.94 9.67 16 279341 11584 46395121
Multiple fractures 29.84 9.67 87 279270 5480 46401225
Tenderness 29.81 9.67 188 279169 16693 46390012
Seizure 29.56 9.67 538 278819 122516 46284189
Speech disorder 29.36 9.67 114 279243 36053 46370652
Swollen joint count increased 29.27 9.67 52 279305 2348 46404357
Skin papilloma 29.19 9.67 72 279285 4104 46402601
Neutrophil count decreased 29.13 9.67 147 279210 43279 46363426
Blood glucose increased 28.96 9.67 283 279074 71730 46334975
Rheumatic fever 28.94 9.67 57 279300 2786 46403919
Disseminated intravascular coagulation 28.91 9.67 43 279314 18962 46387743
Pulmonary embolism 28.91 9.67 466 278891 108119 46298586
Tenosynovitis stenosans 28.79 9.67 46 279311 1903 46404802
Synovial cyst 28.67 9.67 103 279254 7243 46399462
Dyspnoea exertional 28.45 9.67 180 279177 50109 46356596
Loss of consciousness 28.32 9.67 466 278891 107772 46298933
Fluid retention 28.21 9.67 184 279173 50862 46355843
Metastases to bone 28.11 9.67 38 279319 17438 46389267
Abnormal behaviour 27.99 9.67 52 279305 21006 46385699
Gastroenteritis viral 27.90 9.67 195 279162 17924 46388781
Depression 27.75 9.67 790 278567 169314 46237391
Joint range of motion decreased 27.69 9.67 170 279187 14954 46391751
Cognitive disorder 27.60 9.67 120 279237 36763 46369942
Posterior reversible encephalopathy syndrome 27.45 9.67 30 279327 15111 46391594
Surgery 27.35 9.67 278 279079 28507 46378198
Extrapyramidal disorder 27.01 9.67 17 279340 11251 46395454
Cellulitis 26.71 9.67 579 278778 69709 46336996
Schizophrenia 26.61 9.67 9 279348 8559 46398146
Skin cancer 26.56 9.67 114 279243 8709 46397996
Fracture 26.39 9.67 179 279178 16292 46390413
Pulmonary tuberculosis 26.39 9.67 75 279282 4656 46402049
Rash 26.38 9.67 2476 276881 354036 46052669
Accidental overdose 26.28 9.67 50 279307 20016 46386689
Latent tuberculosis 25.91 9.67 44 279313 1916 46404789
Product administration error 25.81 9.67 49 279308 19632 46387073
Gamma-glutamyltransferase increased 25.79 9.67 100 279257 31640 46375065
Feeling abnormal 25.47 9.67 562 278795 124498 46282207
Cerebral haemorrhage 25.29 9.67 86 279271 28285 46378420
Anaphylactic shock 25.27 9.67 52 279305 20222 46386483
Injection site haemorrhage 25.23 9.67 211 279146 20498 46386207
Ventricular tachycardia 25.22 9.67 39 279318 16928 46389777
Thrombocytopenia 25.16 9.67 571 278786 126010 46280695
Unresponsive to stimuli 25.11 9.67 103 279254 32071 46374634
Polyarthritis 24.92 9.67 91 279266 6451 46400254
Placental disorder 24.69 9.67 36 279321 1373 46405332
Disability 24.44 9.67 123 279234 10044 46396661
Contusion 24.37 9.67 691 278666 86796 46319909
Pancytopenia 24.31 9.67 674 278683 84384 46322321
Muscle spasms 24.29 9.67 556 278801 122557 46284148
Angioedema 24.26 9.67 137 279220 39205 46367500
Acute generalised exanthematous pustulosis 24.23 9.67 13 279344 9392 46397313
Drug level increased 24.10 9.67 46 279311 18395 46388310
Ventricular fibrillation 24.09 9.67 20 279337 11476 46395229
Foetal death 24.07 9.67 110 279247 8633 46398072
Mouth ulceration 24.01 9.67 256 279101 26576 46380129
Synovial fluid analysis 23.83 9.67 35 279322 1344 46405361
Blood creatinine increased 23.77 9.67 318 279039 76085 46330620
Suicidal ideation 23.77 9.67 219 279138 56163 46350542
Acute hepatic failure 23.69 9.67 32 279325 14689 46392016
Myocardial infarction 23.55 9.67 426 278931 97102 46309603
Squamous cell carcinoma 23.40 9.67 101 279256 7735 46398970
Inappropriate antidiuretic hormone secretion 23.36 9.67 30 279327 14072 46392633
Injection site haematoma 23.26 9.67 85 279272 6027 46400678
Torsade de pointes 23.25 9.67 23 279334 12131 46394574
Blood pressure decreased 23.24 9.67 224 279133 56935 46349770
Atrial septal defect 23.21 9.67 87 279270 6245 46400460
Hypersensitivity 23.20 9.67 1111 278246 149210 46257495
Toxic skin eruption 23.06 9.67 24 279333 12363 46394342
Metastases to liver 22.95 9.67 52 279305 19533 46387172
Anaemia 22.93 9.67 1274 278083 254505 46152200
Aspartate aminotransferase increased 22.90 9.67 332 279025 78368 46328337
Blood bilirubin increased 22.77 9.67 116 279241 34068 46372637
Polyhydramnios 22.71 9.67 42 279315 1957 46404748
Body height below normal 22.63 9.67 40 279317 1799 46404906
Neuroleptic malignant syndrome 22.51 9.67 20 279337 11102 46395603
Acute chest syndrome 22.42 9.67 22 279335 548 46406157
Dysgeusia 22.35 9.67 146 279211 40345 46366360
Blood pressure increased 22.35 9.67 949 278408 125717 46280988
Brain oedema 22.32 9.67 25 279332 12453 46394252
Dehydration 22.11 9.67 757 278600 158783 46247922
Nightmare 22.05 9.67 41 279316 16557 46390148
Antinuclear antibody positive 21.96 9.67 85 279272 6195 46400510
Psychotic disorder 21.96 9.67 66 279291 22555 46384150
Immunodeficiency 21.94 9.67 144 279213 12962 46393743
Cystitis 21.91 9.67 365 278992 41876 46364829
Immunosuppression 21.88 9.67 96 279261 7404 46399301
Blood alkaline phosphatase increased 21.77 9.67 143 279214 39466 46367239
Ascites 21.70 9.67 129 279228 36455 46370250
Febrile bone marrow aplasia 21.68 9.67 7 279350 6855 46399850
Immune reconstitution inflammatory syndrome 21.67 9.67 4 279353 5721 46400984
Arrhythmia 21.66 9.67 121 279236 34720 46371985
Device dislocation 21.61 9.67 63 279294 21739 46384966
Vertigo 21.58 9.67 203 279154 51845 46354860
Loose body in joint 21.51 9.67 29 279328 1027 46405678
Muscle spasticity 21.49 9.67 22 279335 11418 46395287
Vision blurred 21.23 9.67 342 279015 79366 46327339
Hospitalisation 21.13 9.67 260 279097 63125 46343580
Chest discomfort 20.95 9.67 397 278960 89872 46316833
Respiratory disorder 20.93 9.67 88 279269 27212 46379493
Akathisia 20.87 9.67 10 279347 7704 46399001
Respiratory distress 20.86 9.67 109 279248 31807 46374898
Dysarthria 20.81 9.67 135 279222 37363 46369342
Clear cell renal cell carcinoma 20.78 9.67 28 279329 991 46405714
Haemoglobin decreased 20.53 9.67 956 278401 127993 46278712
Pulmonary fibrosis 20.52 9.67 197 279160 19895 46386810
Gestational hypertension 20.49 9.67 42 279315 2113 46404592
Breast feeding 20.48 9.67 26 279331 867 46405838
Multiple sclerosis 20.21 9.67 78 279279 24713 46381992
C-reactive protein increased 20.18 9.67 476 278881 58114 46348591
Scleritis 20.13 9.67 50 279307 2862 46403843
Diabetes mellitus inadequate control 20 9.67 30 279327 13184 46393521
Congenital arterial malformation 19.99 9.67 17 279340 350 46406355
Neurotoxicity 19.94 9.67 32 279325 13685 46393020
Wheelchair user 19.93 9.67 61 279296 3947 46402758
Product adhesion issue 19.78 9.67 3 279354 4952 46401753
Fear 19.72 9.67 42 279315 16130 46390575
Complication of device insertion 19.72 9.67 3 279354 4941 46401764
Jaundice 19.71 9.67 97 279260 28748 46377957
Cushingoid 19.67 9.67 82 279275 6184 46400521
Poor venous access 19.61 9.67 100 279257 8208 46398497
Joint injury 19.45 9.67 188 279169 19021 46387684
Tooth infection 19.37 9.67 133 279224 12153 46394552
Chronic kidney disease 19.35 9.67 154 279203 40717 46365988
Alanine aminotransferase increased 19.31 9.67 393 278964 88058 46318647
Injection site irritation 19.26 9.67 63 279294 4224 46402481
Memory impairment 19.24 9.67 336 279021 77001 46329704
Joint noise 19.23 9.67 52 279305 3135 46403570
Atrioventricular block complete 18.99 9.67 11 279346 7616 46399089
Pain in jaw 18.91 9.67 143 279214 38229 46368476
Serum ferritin increased 18.88 9.67 72 279285 5211 46401494
Stillbirth 18.87 9.67 83 279274 6408 46400297
Diverticulitis 18.83 9.67 290 279067 32749 46373956
Oedema 18.80 9.67 285 279072 66786 46339919
Deep vein thrombosis 18.77 9.67 350 279007 79423 46327282
Arthritis bacterial 18.74 9.67 76 279281 5660 46401045
Bradyphrenia 18.57 9.67 7 279350 6223 46400482
Palpitations 18.56 9.67 431 278926 94828 46311877
Injury 18.56 9.67 171 279186 43856 46362849
Wheezing 18.55 9.67 217 279140 53169 46353536
Injection site urticaria 18.55 9.67 129 279228 11838 46394867
Transplant rejection 18.54 9.67 18 279339 9578 46397127
Cytokine release syndrome 18.54 9.67 7 279350 6216 46400489
Laryngitis 18.52 9.67 107 279250 9209 46397496
Synovial disorder 18.50 9.67 24 279333 818 46405887
Bone disorder 18.33 9.67 192 279165 19841 46386864
Device use error 18.29 9.67 4 279353 5077 46401628
Fluid overload 18.24 9.67 92 279265 27093 46379612
Premature baby 18.21 9.67 177 279180 17935 46388770
Bronchospasm 18.16 9.67 42 279315 15665 46391040
Spinal stenosis 18.16 9.67 133 279224 12410 46394295
Balance disorder 18.14 9.67 274 279083 64247 46342458
Bone pain 18.13 9.67 186 279171 46704 46360001
Bursitis 18.07 9.67 190 279167 19652 46387053
Foot fracture 18.07 9.67 188 279169 19394 46387311
Antibody test positive 18.05 9.67 40 279317 2125 46404580
Polyneuropathy 18.05 9.67 26 279331 11618 46395087
Human antichimeric antibody positive 18.01 9.67 31 279326 1365 46405340
Pharyngitis streptococcal 17.98 9.67 99 279258 8369 46398336
Agranulocytosis 17.96 9.67 70 279287 22115 46384590
Exomphalos 17.92 9.67 19 279338 520 46406185
Face oedema 17.80 9.67 57 279300 19096 46387609
Asphyxia 17.61 9.67 5 279352 5321 46401384
Acute myeloid leukaemia 17.60 9.67 43 279314 15735 46390970
Pyrexia 17.59 9.67 1823 277534 346979 46059726
Joint dislocation 17.58 9.67 121 279236 11065 46395640
Crying 17.57 9.67 66 279291 21075 46385630
Ischaemic stroke 17.55 9.67 47 279310 16675 46390030
Post procedural infection 17.43 9.67 90 279267 7423 46399282
Tenosynovitis 17.42 9.67 90 279267 7425 46399280
Uterine perforation 17.37 9.67 11 279346 7256 46399449
White blood cell count decreased 17.34 9.67 525 278832 111706 46294999
Cervical incompetence 17.33 9.67 20 279337 603 46406102
Bone density abnormal 17.31 9.67 49 279308 3035 46403670
Eosinophilia 17.30 9.67 58 279299 19159 46387546
Leukopenia 17.30 9.67 296 279061 68047 46338658
Cholestasis of pregnancy 17.25 9.67 27 279330 1097 46405608
Haemorrhage 17.20 9.67 228 279129 54641 46352064
Knee operation 17.07 9.67 65 279292 4701 46402004
International normalised ratio increased 16.90 9.67 189 279168 46694 46360011
Dry eye 16.84 9.67 265 279092 30057 46376648
Withdrawal syndrome 16.83 9.67 54 279303 18080 46388625
Orthostatic hypotension 16.80 9.67 83 279274 24575 46382130
Erythema multiforme 16.75 9.67 20 279337 9684 46397021
Hypomania 16.75 9.67 3 279354 4385 46402320
Thrombotic microangiopathy 16.73 9.67 15 279342 8291 46398414
Acute respiratory failure 16.63 9.67 104 279253 29034 46377671
Rotator cuff repair 16.59 9.67 31 279326 1456 46405249
Talipes 16.54 9.67 30 279327 1377 46405328
Coagulopathy 16.54 9.67 56 279301 18443 46388262
Metastases to central nervous system 16.48 9.67 26 279331 11195 46395510
Blood iron increased 16.44 9.67 29 279328 1302 46405403
Aggression 16.41 9.67 75 279282 22669 46384036
Foetal distress syndrome 16.39 9.67 28 279329 1225 46405480
Infection 16.32 9.67 966 278391 132626 46274079
Platelet count decreased 16.18 9.67 465 278892 99559 46307146
Irritability 16.17 9.67 104 279253 28842 46377863
Paralysis 16.12 9.67 17 279340 8704 46398001
Anhedonia 16.10 9.67 23 279334 10312 46396393
Hiatus hernia 16.08 9.67 174 279183 18128 46388577
Dactylitis 16.06 9.67 27 279330 1166 46405539
Mania 16.05 9.67 25 279332 10821 46395884
Miosis 16.01 9.67 10 279347 6647 46400058
Tumour lysis syndrome 15.90 9.67 12 279345 7224 46399481
Joint lock 15.87 9.67 37 279320 2034 46404671
Skin laceration 15.84 9.67 175 279182 18327 46388378
Haemorrhage in pregnancy 15.80 9.67 32 279325 1596 46405109
Stress cardiomyopathy 15.75 9.67 14 279343 7770 46398935
Hallucination, auditory 15.72 9.67 25 279332 10731 46395974
Graft versus host disease 15.71 9.67 10 279347 6578 46400127
Status epilepticus 15.67 9.67 38 279319 13941 46392764
Fracture delayed union 15.65 9.67 38 279319 2144 46404561
Dyskinesia 15.61 9.67 105 279252 28820 46377885
Substance abuse 15.58 9.67 3 279354 4164 46402541
Injection site extravasation 15.55 9.67 81 279276 6704 46400001
Device difficult to use 15.48 9.67 15 279342 7989 46398716
Melaena 15.40 9.67 100 279257 27672 46379033
Maternal exposure before pregnancy 15.14 9.67 60 279297 4421 46402284
Eye infection 15.13 9.67 100 279257 9023 46397682
Cyst 15.12 9.67 124 279233 11976 46394729
Hypomagnesaemia 15.00 9.67 75 279282 22135 46384570
Carpal tunnel syndrome 14.98 9.67 153 279204 15706 46390999
Body temperature decreased 14.97 9.67 134 279223 13275 46393430
Lung neoplasm malignant 14.91 9.67 150 279207 15339 46391366
Joint warmth 14.88 9.67 27 279330 1240 46405465
Acute graft versus host disease 14.86 9.67 3 279354 4027 46402678
Viral infection 14.85 9.67 259 279098 29976 46376729
Sickle cell anaemia 14.80 9.67 18 279339 574 46406131
Tardive dyskinesia 14.75 9.67 14 279343 7529 46399176
Lymphoma 14.75 9.67 105 279252 9708 46396997
Ingrown hair 14.69 9.67 16 279341 452 46406253
Obstructive airways disorder 14.61 9.67 37 279320 13375 46393330
Pancreatitis acute 14.59 9.67 88 279269 24784 46381921
Hyperuricaemia 14.57 9.67 5 279352 4712 46401993
Cytopenia 14.52 9.67 15 279342 7753 46398952
Ketoacidosis 14.47 9.67 3 279354 3952 46402753
Lymphadenectomy 14.42 9.67 22 279335 874 46405831
Maternal exposure during breast feeding 14.39 9.67 43 279314 2746 46403959
Psychomotor hyperactivity 14.38 9.67 22 279335 9591 46397114
Second primary malignancy 14.37 9.67 11 279346 6573 46400132
Pulmonary hypertension 14.23 9.67 142 279215 35851 46370854
Abortion missed 14.20 9.67 30 279327 1542 46405163
Rash maculo-papular 14.15 9.67 103 279254 27771 46378934
Parkinsonism 14.13 9.67 16 279341 7932 46398773
Atrioventricular block 14.09 9.67 12 279345 6799 46399906
Cerebrovascular accident 14.08 9.67 479 278878 100560 46306145
Breast cancer metastatic 13.94 9.67 39 279318 13639 46393066
Red blood cell sedimentation rate 13.94 9.67 32 279325 1741 46404964
Ear infection 13.89 9.67 204 279153 22809 46383896
Tendon disorder 13.87 9.67 63 279294 4932 46401773
Induced labour 13.74 9.67 22 279335 912 46405793
Catheter site pain 13.69 9.67 3 279354 3803 46402902
Lupus-like syndrome 13.63 9.67 87 279270 7757 46398948
Crohn's disease 13.61 9.67 78 279279 6693 46400012
Lung neoplasm 13.48 9.67 69 279288 5671 46401034
Hyperlipidaemia 13.46 9.67 61 279296 18478 46388227
Autism spectrum disorder 13.44 9.67 17 279340 565 46406140
Wound infection pseudomonas 13.42 9.67 28 279329 1427 46405278
Mood altered 13.32 9.67 37 279320 12970 46393735
Pleural effusion 13.32 9.67 386 278971 82566 46324139
Panic attack 13.30 9.67 69 279288 20173 46386532
Foetal anticonvulsant syndrome 13.29 9.67 15 279342 441 46406264
Limb injury 13.20 9.67 174 279183 19000 46387705
Anterior chamber cleavage syndrome 13.17 9.67 10 279347 174 46406531
Myoclonus 13.14 9.67 43 279314 14309 46392396
Pemphigoid 13.08 9.67 9 279348 5682 46401023
Cardiogenic shock 13.07 9.67 52 279305 16332 46390373
Incorrect route of product administration 13.07 9.67 52 279305 16331 46390374
Injection site induration 13.06 9.67 88 279269 7991 46398714
Genital haemorrhage 13.06 9.67 12 279345 6554 46400151
Pulmonary oedema 13.04 9.67 221 279136 50884 46355821
Cholecystitis chronic 13.02 9.67 27 279330 10472 46396233
Lymphatic fistula 13.00 9.67 21 279336 877 46405828
Pleuritic pain 12.96 9.67 74 279283 6342 46400363
Crystal nephropathy 12.92 9.67 20 279337 805 46405900
Rhinorrhoea 12.86 9.67 375 278982 47290 46359415
Femoral hernia incarcerated 12.81 9.67 21 279336 888 46405817
Upper respiratory tract infection 12.78 9.67 483 278874 63073 46343632
Weight decreased 12.78 9.67 1445 277912 209404 46197301
Foetal growth restriction 12.78 9.67 75 279282 6492 46400213
Mass 12.77 9.67 116 279241 11537 46395168
Human anti-human antibody test 12.77 9.67 13 279344 339 46406366
Forceps delivery 12.74 9.67 10 279347 183 46406522
Placental insufficiency 12.73 9.67 26 279331 1305 46405400
Flushing 12.68 9.67 292 279065 64322 46342383
Atrial fibrillation 12.66 9.67 499 278858 103091 46303614
Shock haemorrhagic 12.65 9.67 20 279337 8604 46398101
Myopathy 12.65 9.67 21 279336 8860 46397845
Glycosylated haemoglobin increased 12.64 9.67 29 279328 10847 46395858
Tonsillitis 12.60 9.67 61 279296 4903 46401802
Dysphagia 12.60 9.67 359 278998 76953 46329752
Cardiac failure acute 12.56 9.67 18 279339 8060 46398645
Pancreatic steatosis 12.55 9.67 22 279335 983 46405722
Endodontic procedure 12.53 9.67 38 279319 2447 46404258
Drug ineffective for unapproved indication 12.52 9.67 53 279304 16360 46390345
Ankylosing spondylitis 12.50 9.67 76 279281 6661 46400044
Frequent bowel movements 12.48 9.67 123 279234 12509 46394196
Ulcer 12.47 9.67 159 279198 17233 46389472
Tachypnoea 12.45 9.67 44 279313 14307 46392398
Haematocrit decreased 12.43 9.67 286 279071 34771 46371934
Dysmorphism 12.41 9.67 32 279325 1875 46404830
Complication associated with device 12.32 9.67 49 279308 15392 46391313
Nail injury 12.32 9.67 14 279343 415 46406290
Vascular rupture 12.32 9.67 25 279332 1249 46405456
Renal injury 12.30 9.67 24 279333 9517 46397188
Vacuum extractor delivery 12.28 9.67 9 279348 148 46406557
Myofascial pain syndrome 12.26 9.67 32 279325 1889 46404816
Photophobia 12.20 9.67 137 279220 14407 46392298
Neonatal respiratory distress syndrome 12.09 9.67 38 279319 2495 46404210
Hypertransaminasaemia 12.05 9.67 3 279354 3485 46403220
Acidosis 12.04 9.67 31 279326 11143 46395562
Off label use 12.03 9.67 2044 277313 377797 46028908
Pancreatitis 12.01 9.67 186 279171 43441 46363264
Disseminated tuberculosis 11.97 9.67 40 279317 2712 46403993
Inflammatory pain 11.94 9.67 17 279340 634 46406071
Infusion site erythema 11.91 9.67 17 279340 7625 46399080
Mycobacterium tuberculosis complex test positive 11.88 9.67 28 279329 1550 46405155
Stevens-Johnson syndrome 11.87 9.67 86 279271 23211 46383494
Wound infection 11.81 9.67 104 279253 10255 46396450
Bone marrow failure 11.75 9.67 117 279240 29552 46377153
Oligohydramnios 11.68 9.67 64 279293 5401 46401304
Cartilage injury 11.66 9.67 28 279329 1569 46405136
Abdominal distension 11.60 9.67 342 279015 73009 46333696
Catatonia 11.60 9.67 4 279353 3758 46402947
Arthropod bite 11.55 9.67 67 279290 5774 46400931
Cerebral infarction 11.55 9.67 87 279270 23279 46383426
Renal mass 11.52 9.67 30 279327 1768 46404937
Wrong technique in product usage process 11.52 9.67 243 279114 54179 46352526
Abortion threatened 11.50 9.67 16 279341 584 46406121
Skin infection 11.49 9.67 111 279246 11228 46395477
Large for dates baby 11.45 9.67 14 279343 449 46406256
Chest pain 11.41 9.67 904 278453 175420 46231285
Kidney infection 11.41 9.67 152 279205 16637 46390068
Drug-induced liver injury 11.36 9.67 97 279260 25271 46381434
Carcinoma in situ of skin 11.36 9.67 10 279347 216 46406489
Oliguria 11.32 9.67 22 279335 8737 46397968
Congenital hydronephrosis 11.31 9.67 13 279344 390 46406315
Transplant dysfunction 11.31 9.67 7 279350 4675 46402030
Myocarditis 11.30 9.67 18 279339 7721 46398984
Blood potassium decreased 11.27 9.67 160 279197 37903 46368802
Hemiparesis 11.26 9.67 72 279285 19997 46386708
Stress at work 11.25 9.67 21 279336 986 46405719
Haematotoxicity 11.23 9.67 15 279342 6918 46399787
Intervertebral disc degeneration 11.19 9.67 125 279232 13127 46393578
Subdural haematoma 11.18 9.67 40 279317 12957 46393748
Ill-defined disorder 11.17 9.67 224 279133 26603 46380102
Proteinuria 11.12 9.67 56 279301 16497 46390208
Respiratory tract infection 11.09 9.67 246 279111 29726 46376979
Aspergillus infection 11.06 9.67 15 279342 6875 46399830
Haemorrhage intracranial 11.05 9.67 39 279318 12685 46394020
Gastroenteritis 11.03 9.67 205 279152 24014 46382691
Catheter site erythema 11.03 9.67 5 279352 3978 46402727
Pathogen resistance 10.99 9.67 12 279345 6048 46400657
Gastrointestinal haemorrhage 10.97 9.67 366 278991 77007 46329698
Decreased insulin requirement 10.94 9.67 8 279349 131 46406574
Patent ductus arteriosus 10.94 9.67 49 279308 3813 46402892
Dystonia 10.82 9.67 33 279324 11224 46395481
Colitis microscopic 10.81 9.67 14 279343 6542 46400163
Tuberculin test positive 10.78 9.67 41 279316 2963 46403742
Chondropathy 10.76 9.67 31 279326 1939 46404766
Drug abuser 10.75 9.67 3 279354 3230 46403475
Haemophagocytic lymphohistiocytosis 10.74 9.67 21 279336 8321 46398384
Nodal osteoarthritis 10.73 9.67 18 279339 776 46405929
Muscular weakness 10.67 9.67 445 278912 91399 46315306
Impaired quality of life 10.63 9.67 43 279314 3199 46403506
Hallucination, visual 10.61 9.67 63 279294 17810 46388895
Delusion 10.61 9.67 33 279324 11155 46395550
Bundle branch block right 10.58 9.67 8 279349 4811 46401894
Bowen's disease 10.56 9.67 10 279347 238 46406467
Fear of injection 10.56 9.67 51 279306 4096 46402609
Metastases to lung 10.53 9.67 31 279326 10665 46396040
Rheumatoid lung 10.52 9.67 28 279329 1672 46405033
Pregnancy with contraceptive device 10.51 9.67 7 279350 4496 46402209
Cytomegalovirus viraemia 10.40 9.67 7 279350 4471 46402234
Intestinal stenosis 10.40 9.67 36 279321 2485 46404220
Salivary hypersecretion 10.38 9.67 14 279343 6431 46400274
Ankle fracture 10.36 9.67 140 279217 15371 46391334
Cold type haemolytic anaemia 10.36 9.67 9 279348 191 46406514
Dementia 10.32 9.67 50 279307 14880 46391825
Inflammatory marker increased 10.31 9.67 62 279295 5413 46401292
Threatened labour 10.29 9.67 18 279339 803 46405902
Complication of pregnancy 10.19 9.67 14 279343 505 46406200
Diabetes mellitus 10.18 9.67 225 279132 49840 46356865
Tooth abscess 10.14 9.67 118 279239 12515 46394190
Unevaluable event 10.12 9.67 205 279152 45970 46360735
Inflammatory bowel disease 10.10 9.67 42 279315 3163 46403542
Normal newborn 10.08 9.67 66 279291 5935 46400770
Occult blood 10.04 9.67 19 279338 901 46405804
Acute pulmonary oedema 10.04 9.67 20 279337 7871 46398834
Cyst rupture 10.02 9.67 13 279344 443 46406262
Tendonitis 10.01 9.67 130 279227 14147 46392558
Oxygen saturation decreased 9.99 9.67 508 278849 68656 46338049
Incorrect product administration duration 9.99 9.67 27 279330 9550 46397155
Osteoporotic fracture 9.96 9.67 40 279317 2965 46403740
Hereditary angioedema 9.92 9.67 11 279346 5505 46401200
Swollen joint count 9.91 9.67 10 279347 258 46406447
Aortic valve stenosis 9.90 9.67 41 279316 3083 46403622
Pharyngitis 9.89 9.67 154 279203 17429 46389276
Morning sickness 9.87 9.67 16 279341 670 46406035
Muscle rupture 9.87 9.67 31 279326 2034 46404671
Injection site discolouration 9.85 9.67 73 279284 6837 46399868
Rheumatoid factor increased 9.84 9.67 24 279333 1358 46405347
Labyrinthitis 9.84 9.67 31 279326 2038 46404667
Urinary retention 9.82 9.67 104 279253 25957 46380748
Product physical issue 9.80 9.67 9 279348 4918 46401787
Dermatitis allergic 9.80 9.67 117 279240 12486 46394219
Nervousness 9.79 9.67 116 279241 28359 46378346
Ileus paralytic 9.72 9.67 7 279350 4316 46402389
Lip swelling 9.71 9.67 101 279256 25294 46381411
Congenital nose malformation 9.69 9.67 10 279347 265 46406440

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 484.84 9.85 700 117703 40497 29793578
Drug abuse 276.62 9.85 11 118392 82061 29752014
Foetal exposure during pregnancy 235.94 9.85 478 117925 36393 29797682
Arthralgia 213.79 9.85 1081 117322 134710 29699365
Completed suicide 189.52 9.85 78 118325 99414 29734661
Toxicity to various agents 185.57 9.85 258 118145 176925 29657150
Psoriatic arthropathy 132.82 9.85 230 118173 15531 29818544
Joint swelling 107.22 9.85 418 117985 46528 29787547
Sickle cell anaemia with crisis 106.47 9.85 83 118320 2319 29831756
Premature baby 100.36 9.85 211 118192 16480 29817595
Drug interaction 93.10 9.85 439 117964 199129 29634946
Exposure during pregnancy 91.24 9.85 145 118258 9116 29824959
Intentional overdose 78.14 9.85 33 118370 41448 29792627
Neonatal respiratory distress syndrome 76.97 9.85 87 118316 3925 29830150
Tenosynovitis 73.95 9.85 80 118323 3435 29830640
Atrial septal defect 73.13 9.85 110 118293 6591 29827484
Enthesopathy 69.82 9.85 71 118332 2835 29831240
Nasopharyngitis 68.82 9.85 433 117970 58416 29775659
Blood pressure fluctuation 67.18 9.85 186 118217 17317 29816758
Overdose 63.73 9.85 150 118253 84187 29749888
Musculoskeletal stiffness 61.50 9.85 293 118110 35588 29798487
Maternal drugs affecting foetus 61.33 9.85 80 118323 4193 29829882
Acute kidney injury 58.50 9.85 748 117655 273094 29560981
Death 58.13 9.85 1029 117374 356254 29477821
Synovitis 56.87 9.85 122 118281 9661 29824414
Hypospadias 56.41 9.85 61 118342 2618 29831457
Suicide attempt 52.30 9.85 41 118362 36656 29797419
Small for dates baby 50.68 9.85 63 118340 3145 29830930
Low birth weight baby 50.31 9.85 88 118315 5988 29828087
Maternal exposure during pregnancy 50.24 9.85 69 118334 3802 29830273
Ventricular septal defect 48.99 9.85 65 118338 3464 29830611
Maternal exposure during breast feeding 48.86 9.85 45 118358 1587 29832488
Tongue disorder 48.67 9.85 72 118331 4250 29829825
Psoriasis 48.59 9.85 311 118092 42195 29791880
Drug reaction with eosinophilia and systemic symptoms 48.53 9.85 26 118377 28462 29805613
Infusion related reaction 48.36 9.85 300 118103 40264 29793811
Dysmorphism 47.95 9.85 49 118354 1968 29832107
Pain 46.32 9.85 948 117455 171693 29662382
C-reactive protein abnormal 46.30 9.85 81 118322 5512 29828563
Hypoglycaemia neonatal 46.14 9.85 43 118360 1540 29832535
Drug intolerance 44.37 9.85 319 118084 44972 29789103
Hepatic function abnormal 43.86 9.85 61 118342 41884 29792191
Pulmonary fibrosis 43.42 9.85 150 118253 15740 29818335
Arthritis 43.08 9.85 201 118202 24200 29809875
Haemoglobin decreased 42.10 9.85 659 117744 113439 29720636
Pancytopenia 40.96 9.85 515 117888 84537 29749538
Lower respiratory tract infection 40.01 9.85 210 118193 26504 29807571
Intentional product misuse 39.78 9.85 47 118356 34620 29799455
Serotonin syndrome 39.27 9.85 11 118392 17880 29816195
Arthropathy 36.78 9.85 171 118232 20556 29813519
Cryptorchism 36.75 9.85 39 118364 1638 29832437
Basal cell carcinoma 36.59 9.85 143 118260 15925 29818150
Coma 36.43 9.85 65 118338 40384 29793691
Osteoarthritis 36.03 9.85 156 118247 18193 29815882
Syndactyly 36.00 9.85 27 118376 711 29833364
Exposure via breast milk 35.23 9.85 37 118366 1535 29832540
Drug resistance 34.85 9.85 18 118385 20115 29813960
Palmar-plantar erythrodysaesthesia syndrome 34.84 9.85 8 118395 14862 29819213
Rhabdomyolysis 34.39 9.85 132 118271 63448 29770627
Large for dates baby 34.16 9.85 28 118375 842 29833233
Blood pressure systolic increased 33.22 9.85 133 118270 14977 29819098
Loss of personal independence in daily activities 32.74 9.85 170 118233 21365 29812710
Foetal anticonvulsant syndrome 32.70 9.85 26 118377 748 29833327
Alanine aminotransferase abnormal 31.48 9.85 45 118358 2574 29831501
Respiratory arrest 31.14 9.85 42 118361 29216 29804859
Product use in unapproved indication 30.90 9.85 168 118235 73525 29760550
Blood pressure increased 30.24 9.85 425 117978 71503 29762572
Drug withdrawal syndrome 29.68 9.85 21 118382 19788 29814287
Blood pressure systolic abnormal 29.45 9.85 33 118370 1474 29832601
Skin cancer 28.98 9.85 83 118320 7878 29826197
Angioedema 28.55 9.85 58 118345 34326 29799749
Intentional self-injury 28.46 9.85 9 118394 13523 29820552
Renal failure 28.28 9.85 350 118053 128616 29705459
Cardiac arrest 28.23 9.85 233 118170 92617 29741458
Musculoskeletal pain 28.06 9.85 214 118189 30726 29803349
Rheumatoid nodule 28.01 9.85 34 118369 1656 29832419
Febrile neutropenia 27.97 9.85 278 118125 106415 29727660
Juvenile idiopathic arthritis 27.87 9.85 27 118376 1016 29833059
Drug dependence 27.65 9.85 26 118377 21269 29812806
Congenital hand malformation 27.18 9.85 19 118384 447 29833628
Pain in extremity 27.16 9.85 598 117805 109623 29724452
Injection site pain 27.13 9.85 209 118194 30101 29803974
Bradycardia 27.13 9.85 150 118253 65376 29768699
Knee arthroplasty 26.93 9.85 65 118338 5565 29828510
Hypoglycaemia 26.83 9.85 107 118296 50874 29783201
Tendonitis 26.60 9.85 81 118322 7955 29826120
Delirium 26.31 9.85 78 118325 40553 29793522
Agitation 26.28 9.85 117 118286 53956 29780119
Hyperglycaemia 26.25 9.85 63 118340 35137 29798938
Peripheral swelling 26.13 9.85 362 118041 60712 29773363
Caesarean section 26.10 9.85 37 118366 2100 29831975
Suicidal ideation 25.87 9.85 66 118337 36048 29798027
Cardiac failure 25.51 9.85 209 118194 83209 29750866
Arthritis bacterial 25.18 9.85 55 118348 4409 29829666
Selective eating disorder 24.90 9.85 32 118371 1652 29832423
Medical device implantation 24.83 9.85 19 118384 516 29833559
Agitation neonatal 24.55 9.85 25 118378 1000 29833075
Cytomegalovirus infection 24.18 9.85 35 118368 23639 29810436
Serum ferritin increased 24.13 9.85 61 118342 5376 29828699
Lactic acidosis 23.97 9.85 55 118348 31158 29802917
Body temperature decreased 23.69 9.85 88 118315 9567 29824508
Foetal growth restriction 23.53 9.85 47 118356 3538 29830537
Talipes 23.48 9.85 31 118372 1644 29832431
Vitamin D deficiency 22.94 9.85 58 118345 5112 29828963
Constipation 22.69 9.85 312 118091 112594 29721481
Hand deformity 22.25 9.85 32 118371 1841 29832234
Poor venous access 21.95 9.85 37 118366 2443 29831632
Somnolence 21.81 9.85 261 118142 96502 29737573
Speech disorder developmental 21.66 9.85 25 118378 1154 29832921
Joint effusion 21.65 9.85 46 118357 3617 29830458
Poisoning 21.52 9.85 9 118394 11373 29822702
Infective pulmonary exacerbation of cystic fibrosis 21.34 9.85 4 118399 8568 29825507
Patent ductus arteriosus 21.34 9.85 42 118361 3127 29830948
Prostate cancer 21.33 9.85 165 118238 23792 29810283
Infection 21.30 9.85 430 117973 77644 29756431
Post procedural infection 21.03 9.85 52 118351 4520 29829555
Pneumonia 20.91 9.85 1562 116841 332744 29501331
Haemangioma congenital 20.80 9.85 17 118386 509 29833566
Hyperbilirubinaemia neonatal 20.61 9.85 19 118384 671 29833404
Lacrimal disorder 20.45 9.85 14 118389 318 29833757
Cellulitis 19.88 9.85 277 118126 46507 29787568
Altered state of consciousness 19.80 9.85 30 118373 19889 29814186
Jaundice neonatal 19.71 9.85 23 118380 1074 29833001
Contraindicated product administered 19.63 9.85 126 118277 17105 29816970
Wound 19.61 9.85 99 118304 12303 29821772
Bradycardia neonatal 19.54 9.85 21 118382 895 29833180
Therapeutic product effect decreased 19.47 9.85 188 118215 28888 29805187
Shock 19.46 9.85 38 118365 22821 29811254
Congenital bladder anomaly 19.08 9.85 13 118390 293 29833782
Anal fistula 19.04 9.85 46 118357 3940 29830135
Psychotic disorder 18.98 9.85 35 118368 21480 29812595
Pathogen resistance 18.78 9.85 5 118398 8405 29825670
Depressed level of consciousness 18.39 9.85 83 118320 38139 29795936
Hallucination 18.34 9.85 116 118287 48943 29785132
Substance abuse 18.15 9.85 3 118400 7037 29827038
Injection site bruising 18.10 9.85 67 118336 7271 29826804
Cleft lip 18.09 9.85 13 118390 320 29833755
Weight decrease neonatal 17.95 9.85 13 118390 324 29833751
Haematocrit decreased 17.92 9.85 193 118210 30506 29803569
Electrocardiogram QT prolonged 17.74 9.85 77 118326 35758 29798317
Malignant melanoma 17.73 9.85 67 118336 7344 29826731
Joint range of motion decreased 17.58 9.85 57 118346 5788 29828287
Foetal disorder 17.52 9.85 17 118386 641 29833434
Lung neoplasm malignant 17.45 9.85 111 118292 15021 29819054
Crohn's disease 17.44 9.85 47 118356 4305 29829770
Arthrodesis 17.42 9.85 14 118389 409 29833666
Ankyloglossia congenital 17.33 9.85 12 118391 278 29833797
Joint stiffness 17.17 9.85 78 118325 9283 29824792
Multiple congenital abnormalities 17.10 9.85 15 118388 496 29833579
Renal aplasia 17.09 9.85 17 118386 661 29833414
Tonsil cancer 17.07 9.85 18 118385 750 29833325
Sedation 16.92 9.85 24 118379 16349 29817726
Multiple organ dysfunction syndrome 16.80 9.85 165 118238 63322 29770753
Peripheral artery thrombosis 16.78 9.85 31 118372 2201 29831874
Blood pressure diastolic increased 16.73 9.85 35 118368 2723 29831352
Hypermobility syndrome 16.66 9.85 11 118392 235 29833840
Drug withdrawal syndrome neonatal 16.65 9.85 38 118365 3137 29830938
Urticaria 16.60 9.85 137 118266 54469 29779606
Septic arthritis staphylococcal 16.47 9.85 14 118389 443 29833632
Congenital anomaly 16.31 9.85 23 118380 1299 29832776
Blood pressure diastolic decreased 16.31 9.85 58 118345 6173 29827902
Blood creatine phosphokinase increased 16.23 9.85 104 118299 43744 29790331
Aggression 16.10 9.85 83 118320 36824 29797251
Arthritis infective 16.05 9.85 34 118369 2668 29831407
Injection site swelling 15.99 9.85 73 118330 8707 29825368
Immunodeficiency 15.85 9.85 45 118358 4249 29829826
Weight decreased 15.66 9.85 738 117665 150183 29683892
Oropharyngeal pain 15.65 9.85 177 118226 28319 29805756
Sinusitis 15.64 9.85 201 118202 33144 29800931
Renal impairment 15.38 9.85 237 118166 83947 29750128
Neck mass 15.36 9.85 23 118380 1372 29832703
Tuberculosis 15.34 9.85 68 118335 8009 29826066
Umbilical hernia 15.14 9.85 40 118363 3621 29830454
Off label use 15.04 9.85 819 117584 248471 29585604
Kidney infection 15.01 9.85 46 118357 4532 29829543
Back disorder 15.01 9.85 55 118348 5939 29828136
Vascular insufficiency 14.98 9.85 12 118391 349 29833726
Mouth ulceration 14.93 9.85 82 118321 10527 29823548
Grip strength decreased 14.92 9.85 29 118374 2139 29831936
Maternal exposure timing unspecified 14.89 9.85 12 118391 352 29833723
Hydrocele 14.88 9.85 28 118375 2016 29832059
Otitis media 14.87 9.85 32 118371 2539 29831536
Autism spectrum disorder 14.81 9.85 22 118381 1303 29832772
Foot deformity 14.67 9.85 38 118365 3399 29830676
Hepatic failure 14.60 9.85 77 118326 33966 29800109
Hypocalcaemia 14.59 9.85 40 118363 21336 29812739
C-reactive protein decreased 14.58 9.85 24 118379 1554 29832521
Hernia pain 14.58 9.85 10 118393 228 29833847
Disease progression 14.54 9.85 225 118178 79649 29754426
Product quality issue 14.48 9.85 33 118370 18741 29815334
Blood insulin increased 14.44 9.85 12 118391 368 29833707
Hypokalaemia 14.33 9.85 128 118275 50064 29784011
Toxic epidermal necrolysis 14.27 9.85 31 118372 17909 29816166
Rash maculo-papular 14.24 9.85 52 118351 25366 29808709
Anal atresia 14.18 9.85 11 118392 305 29833770
Emphysema 14.13 9.85 74 118329 9328 29824747
Back pain 14.13 9.85 517 117886 102079 29731996
Developmental delay 13.97 9.85 28 118375 2113 29831962
Neonatal seizure 13.92 9.85 13 118390 467 29833608
Blood pressure diastolic abnormal 13.86 9.85 21 118382 1266 29832809
Heart rate decreased 13.69 9.85 135 118268 20859 29813216
Plagiocephaly 13.64 9.85 11 118392 323 29833752
Acute hepatic failure 13.60 9.85 16 118387 11811 29822264
Agranulocytosis 13.57 9.85 43 118360 21899 29812176
Red blood cell sedimentation rate increased 13.54 9.85 61 118342 7234 29826841
Pyrexia 13.53 9.85 992 117411 293497 29540578
Palindromic rheumatism 13.48 9.85 9 118394 196 29833879
Diverticular perforation 13.43 9.85 35 118368 3142 29830933
Pleural fibrosis 13.39 9.85 22 118381 1422 29832653
Excessive cerumen production 13.38 9.85 10 118393 262 29833813
Foetal distress syndrome 13.37 9.85 18 118385 973 29833102
Respiratory rate increased 13.29 9.85 70 118333 8845 29825230
Injection site erythema 13.28 9.85 97 118306 13737 29820338
Foetal heart rate deceleration abnormality 13.20 9.85 12 118391 416 29833659
Pulmonary artery stenosis congenital 13.18 9.85 13 118390 500 29833575
Gangrene neonatal 13.13 9.85 9 118394 205 29833870
Neuroleptic malignant syndrome 13.09 9.85 28 118375 16267 29817808
Haemolysis 13.08 9.85 60 118343 7171 29826904
Cytokine release syndrome 13.04 9.85 12 118391 9921 29824154
Steatorrhoea 13.02 9.85 15 118388 691 29833384
Pyelocaliectasis 13.00 9.85 18 118385 999 29833076
Knee deformity 12.95 9.85 11 118392 348 29833727
Hypertriglyceridaemia 12.92 9.85 8 118395 8090 29825985
Asthma 12.78 9.85 87 118316 36087 29797988
Proteinuria 12.76 9.85 28 118375 16117 29817958
Status epilepticus 12.71 9.85 15 118388 11057 29823018
Congenital diaphragmatic hernia 12.68 9.85 9 118394 217 29833858
Pulmonary toxicity 12.66 9.85 43 118360 4473 29829602
Injection site haemorrhage 12.63 9.85 63 118340 7792 29826283
Immunosuppression 12.56 9.85 47 118356 5128 29828947
Lung neoplasm 12.49 9.85 43 118360 4503 29829572
Foetal hypokinesia 12.48 9.85 11 118392 366 29833709
Dermatitis psoriasiform 12.46 9.85 19 118384 1152 29832923
Hepatocellular injury 12.44 9.85 55 118348 25416 29808659
Diabetic ketoacidosis 12.41 9.85 28 118375 15958 29818117
No adverse event 12.34 9.85 32 118371 17387 29816688
Incorrect route of product administration 12.28 9.85 16 118387 11299 29822776
Moaning 12.20 9.85 15 118388 740 29833335
Joint instability 12.04 9.85 11 118392 384 29833691
Mean cell volume increased 11.90 9.85 26 118377 2084 29831991
Lung cancer metastatic 11.89 9.85 29 118374 2499 29831576
Finger deformity 11.86 9.85 17 118386 975 29833100
Congenital hydronephrosis 11.84 9.85 14 118389 663 29833412
Upper respiratory tract infection 11.80 9.85 163 118240 27313 29806762
Hepatic siderosis 11.68 9.85 8 118395 182 29833893
Folate deficiency 11.64 9.85 17 118386 992 29833083
Drug-induced liver injury 11.60 9.85 44 118359 21230 29812845
Non-Hodgkin's lymphoma 11.54 9.85 23 118380 1728 29832347
Pancreatic duct stenosis 11.49 9.85 8 118395 187 29833888
Hypotonia neonatal 11.38 9.85 17 118386 1012 29833063
Spina bifida 11.34 9.85 10 118393 333 29833742
Vitamin B12 deficiency 11.33 9.85 29 118374 2576 29831499
Venoocclusive liver disease 11.31 9.85 6 118397 6607 29827468
Cholelithiasis 11.27 9.85 126 118277 20099 29813976
Red blood cell count decreased 11.24 9.85 156 118247 26165 29807910
Hypoxia 11.19 9.85 128 118275 47726 29786349
Cerebral haemorrhage 11.17 9.85 80 118323 32807 29801268
Subdural haematoma 11.17 9.85 38 118365 18934 29815141
Osteonecrosis of jaw 11.16 9.85 37 118366 18581 29815494
Stevens-Johnson syndrome 11.15 9.85 34 118369 17522 29816553
Squamous cell carcinoma 11.09 9.85 74 118329 10176 29823899
Drug eruption 11.09 9.85 34 118369 17492 29816583
Hepatitis 11.08 9.85 48 118355 22308 29811767
Retinopathy hypertensive 11.03 9.85 9 118394 269 29833806
Intellectual disability 10.97 9.85 15 118388 823 29833252
Abnormal behaviour 10.96 9.85 58 118345 25565 29808510
Cholestasis 10.94 9.85 56 118347 24894 29809181
Tooth fracture 10.91 9.85 33 118370 3229 29830846
Pulmonary tuberculosis 10.87 9.85 43 118360 4814 29829261
Ankylosing spondylitis 10.85 9.85 41 118362 4493 29829582
Lipase increased 10.79 9.85 11 118392 8665 29825410
Necrotising fasciitis streptococcal 10.79 9.85 7 118396 145 29833930
Oxygen saturation decreased 10.78 9.85 236 118167 43204 29790871
Pulmonary valve stenosis 10.71 9.85 10 118393 359 29833716
Exostosis 10.67 9.85 34 118369 3421 29830654
Skin lesion 10.67 9.85 116 118287 18378 29815697
Placental insufficiency 10.66 9.85 6 118397 95 29833980
Maternal exposure before pregnancy 10.64 9.85 10 118393 362 29833713
Nephrolithiasis 10.58 9.85 147 118256 24663 29809412
Haemoglobinuria 10.57 9.85 12 118391 544 29833531
Colitis ulcerative 10.50 9.85 95 118308 14339 29819736
Decreased vibratory sense 10.46 9.85 10 118393 370 29833705
Inflammation 10.42 9.85 133 118270 21893 29812182
Skin graft failure 10.42 9.85 7 118396 154 29833921
Mesothelioma 10.38 9.85 11 118392 461 29833614
Polydactyly 10.37 9.85 18 118385 1217 29832858
Congenital aortic valve incompetence 10.34 9.85 7 118396 156 29833919
Neurotoxicity 10.30 9.85 23 118380 13159 29820916
Anti-erythropoietin antibody positive 10.23 9.85 15 118388 878 29833197
Nose deformity 10.23 9.85 7 118396 159 29833916
Appendix disorder 10.22 9.85 12 118391 564 29833511
Influenza 10.21 9.85 234 118169 43164 29790911
Tachycardia 10.18 9.85 218 118185 73521 29760554
Foetal exposure timing unspecified 10.09 9.85 8 118395 229 29833846
Arthropod bite 9.99 9.85 26 118377 2332 29831743

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:50733 nutritional supplement

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
(1ML) EQ 0.3MG COPPER/ML;EQ 55MCG BASE/ML;EQ 60MCG BASE/ML;EQ 3MG BASE/ML TRALEMENT AM REGENT N209376 July 2, 2020 RX SOLUTION INTRAVENOUS April 30, 2024 NEW CHEMICAL ENTITY
(5ML) EQ 0.3MG COPPER/ML;EQ 55MCG BASE/ML;EQ 60MCG BASE/ML;EQ 3MG BASE/ML TRALEMENT AM REGENT N209376 Dec. 2, 2020 RX SOLUTION INTRAVENOUS April 30, 2024 NEW CHEMICAL ENTITY

Bioactivity Summary:

None

External reference:

IDSource
D04854 KEGG_DRUG
4017709 VUID
N0000179176 NUI
10034-96-5 SECONDARY_CAS_RN
4017681 VANDF
4017709 VANDF
C0065649 UMLSCUI
CHEBI:86364 CHEBI
CHEMBL1200557 ChEMBL_ID
CHEMBL2103742 ChEMBL_ID
C039798 MESH_SUPPLEMENTAL_RECORD_UI
W00LYS4T26 UNII
24580 PUBCHEM_CID
29268 RXNORM
1544 MMSL
33690 MMSL
5021 MMSL
d00434 MMSL
000858 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Multitrace-4 Neonatal HUMAN PRESCRIPTION DRUG LABEL 4 0517-6202 INJECTION, SOLUTION 77 mg INTRAVENOUS UNULLPPROVED DRUG OTHER 14 sections
Manganese Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0517-6410 INJECTION, SOLUTION 0.10 mg INTRAVENOUS UNULLPPROVED DRUG OTHER 13 sections
Multitrace-5 HUMAN PRESCRIPTION DRUG LABEL 5 0517-8201 INJECTION, SOLUTION, CONCENTRATE 1.54 mg INTRAVENOUS UNULLPPROVED DRUG OTHER 14 sections
Multitrace-5 HUMAN PRESCRIPTION DRUG LABEL 5 0517-8210 INJECTION, SOLUTION, CONCENTRATE 1.54 mg INTRAVENOUS UNULLPPROVED DRUG OTHER 14 sections
Multitrace-5 HUMAN PRESCRIPTION DRUG LABEL 5 0517-8510 INJECTION, SOLUTION 0.31 mg INTRAVENOUS UNULLPPROVED DRUG OTHER 14 sections
Multitrace -4 Pediatric HUMAN PRESCRIPTION DRUG LABEL 4 0517-9203 INJECTION, SOLUTION, CONCENTRATE 77 ug INTRAVENOUS UNULLPPROVED DRUG OTHER 14 sections
Tralement HUMAN PRESCRIPTION DRUG LABEL 4 0517-9305 INJECTION, SOLUTION 55 ug INTRAVENOUS NDA 22 sections
Trace Elements 4 HUMAN PRESCRIPTION DRUG LABEL 4 0517-9310 INJECTION, SOLUTION 92.30 ug INTRAVENOUS UNULLPPROVED DRUG OTHER 14 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 1.30 mg ORAL unapproved drug other 19 sections
Centratex HUMAN PRESCRIPTION DRUG LABEL 13 23359-100 CAPSULE 1.30 mg ORAL Unapproved drug other 13 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 1.30 mg ORAL unapproved drug other 13 sections
PureVit DualFe Plus HUMAN PRESCRIPTION DRUG LABEL 13 59088-112 CAPSULE 1.30 mg ORAL unapproved drug other 12 sections
Vitrexyl HUMAN PRESCRIPTION DRUG LABEL 17 59088-164 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Vitrexyl plus Iron HUMAN PRESCRIPTION DRUG LABEL 18 59088-165 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Prenatrix HUMAN PRESCRIPTION DRUG LABEL 20 59088-166 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Vitrexate HUMAN PRESCRIPTION DRUG LABEL 17 59088-167 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Vitrexate FE HUMAN PRESCRIPTION DRUG LABEL 18 59088-168 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Prenatryl HUMAN PRESCRIPTION DRUG LABEL 20 59088-169 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Vitranol HUMAN PRESCRIPTION DRUG LABEL 17 59088-171 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Prometa HUMAN PRESCRIPTION DRUG LABEL 20 59088-172 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Vitranol Fe HUMAN PRESCRIPTION DRUG LABEL 18 59088-173 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Venexa HUMAN PRESCRIPTION DRUG LABEL 17 59088-176 TABLET 2.30 mg ORAL unapproved drug other 11 sections
Venexa FE HUMAN PRESCRIPTION DRUG LABEL 18 59088-177 TABLET 2.30 mg ORAL unapproved drug other 13 sections
Pretrate HUMAN PRESCRIPTION DRUG LABEL 20 59088-178 TABLET 2.60 mg ORAL unapproved drug other 13 sections
Zintrexyl-C HUMAN PRESCRIPTION DRUG LABEL 24 59088-180 TABLET 0.75 mg ORAL unapproved drug other 13 sections
Folitin-Z HUMAN PRESCRIPTION DRUG LABEL 24 59088-181 TABLET 0.75 mg ORAL unapproved drug other 13 sections
Ribotin-E HUMAN PRESCRIPTION DRUG LABEL 24 59088-182 TABLET 0.75 mg ORAL unapproved drug other 13 sections
Ventrixyl HUMAN PRESCRIPTION DRUG LABEL 17 59088-186 TABLET 2.30 mg ORAL unapproved drug other 11 sections