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Stem definition	Drug id	CAS RN
anxiolytics, buspirone derivatives	437	36505-84-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: buspirone buspin buspirone hydrochloride buspirone HCl	An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM. Molecular weight: 385.51 Formula: C21H31N5O2 CLOGP: 2.24 LIPINSKI: 0 HAC: 7 HDO: 0 TPSA: 69.64 ALOGS: -2.82 ROTB: 6 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

buspirone
buspin
buspirone hydrochloride
buspirone HCl

An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.

Molecular weight: 385.51
Formula: C21H31N5O2
CLOGP: 2.24
LIPINSKI: 0
HAC: 7
HDO: 0
TPSA: 69.64
ALOGS: -2.82
ROTB: 6

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
30	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.02 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.10 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	2.59 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	3.90 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
mdck-mdr1-bcrp-efflux	MDCK-MDR1-BCRP efflux ratio	0.387		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pld-class	Phospholipidosis risk class (1 = positive, 0 = negative)	1		High	1
rat-kpuu-brain	Rat brain Kpuu	0.191	%	High	1

Approvals:

Date	Agency	Company	Orphan
Sept. 29, 1986	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	814.11	12.22	605	39943	144453	90443446
Serotonin syndrome	318.40	12.22	203	40345	37684	90550215
Suicidal ideation	242.04	12.22	226	40322	73629	90514270
Depression	171.35	12.22	400	40148	300201	90287698
Anxiety	163.41	12.22	400	40148	309372	90278527
Product dose omission issue	159.56	12.22	382	40166	291305	90296594
Dermatitis atopic	145.07	12.22	104	40444	23368	90564531
Toxicity to various agents	137.45	12.22	358	40190	287488	90300411
Product administration interrupted	133.25	12.22	78	40470	12414	90575485
Glossodynia	129.60	12.22	3	40545	321776	90266123
Synovitis	116.46	12.22	8	40540	329744	90258155
Hand deformity	111.41	12.22	5	40543	296357	90291542
Contraindicated product administered	106.83	12.22	10	40538	320129	90267770
Suspected suicide	97.48	12.22	58	40490	9510	90578389
Systemic lupus erythematosus	94.27	12.22	23	40525	361873	90226026
Infusion related reaction	91.54	12.22	36	40512	416744	90171155
Withdrawal syndrome	87.68	12.22	76	40472	22448	90565451
General physical health deterioration	84.24	12.22	27	40521	355088	90232811
Wound	83.44	12.22	17	40531	302963	90284936
Injection site pain	76.69	12.22	210	40338	173489	90414410
Impaired healing	76.32	12.22	8	40540	234191	90353708
Helicobacter infection	75.89	12.22	7	40541	226843	90361056
Drug intolerance	75.75	12.22	54	40494	447537	90140362
Arthropathy	75.04	12.22	35	40513	366207	90221692
Folliculitis	75.01	12.22	4	40544	204349	90383550
Intentional overdose	74.37	12.22	143	40405	93691	90494208
Hepatic enzyme increased	71.58	12.22	36	40512	360700	90227199
Tremor	71.44	12.22	189	40359	152984	90434915
Lower respiratory tract infection	69.14	12.22	14	40534	250645	90337254
Treatment failure	68.79	12.22	25	40523	303903	90283996
Cardio-respiratory arrest	66.51	12.22	109	40439	63031	90524868
Panic attack	66.49	12.22	70	40478	26295	90561604
Muscle injury	66.29	12.22	3	40545	176651	90411248
Disturbance in attention	63.24	12.22	91	40457	47018	90540881
Joint swelling	61.62	12.22	81	40467	503219	90084680
Feeling abnormal	60.19	12.22	188	40360	167047	90420852
Drug withdrawal syndrome	58.18	12.22	68	40480	28655	90559244
Bezoar	57.78	12.22	27	40521	2707	90585192
Swelling	57.08	12.22	62	40486	418996	90168903
Illness	56.65	12.22	118	40430	81851	90506048
COVID-19	56.39	12.22	185	40363	168658	90419241
Somnolence	55.99	12.22	213	40335	208871	90379028
Liver injury	55.12	12.22	6	40542	170561	90417338
Corneal reflex decreased	54.88	12.22	15	40533	306	90587593
Blister	51.23	12.22	25	40523	254973	90332926
Surgery	50.70	12.22	80	40468	44807	90543092
Depressed mood	49.28	12.22	84	40464	50138	90537761
Agitation	49.21	12.22	99	40449	66999	90520900
Suicide attempt	49.16	12.22	106	40442	75293	90512606
Stomatitis	47.94	12.22	32	40516	274666	90313233
Complication of device insertion	46.35	12.22	38	40510	10398	90577501
Sleep disorder due to general medical condition, insomnia type	45.75	12.22	3	40545	128691	90459208
Febrile neutropenia	45.45	12.22	8	40540	158341	90429558
Mobility decreased	45.41	12.22	28	40520	250706	90337193
Tardive dyskinesia	44.82	12.22	38	40510	10892	90577007
Dry skin	44.47	12.22	112	40436	87961	90499938
Dissociation	44.37	12.22	31	40517	6684	90581215
Pre-existing condition improved	44.15	12.22	35	40513	9134	90578765
Endocarditis enterococcal	43.80	12.22	12	40536	247	90587652
C-reactive protein increased	42.61	12.22	14	40534	181375	90406524
Drug abuse	41.87	12.22	105	40443	82242	90505657
Stress	41.61	12.22	104	40444	81291	90506608
Thrombocytopenia	41.11	12.22	21	40527	208704	90379195
Overdose	40.83	12.22	159	40389	157550	90430349
Product dose omission in error	40.63	12.22	48	40500	20455	90567444
Alopecia	39.81	12.22	103	40445	494968	90092931
Bursitis	39.23	12.22	6	40542	131648	90456251
Drug screen false positive	38.99	12.22	15	40533	928	90586971
Inflammation	38.22	12.22	16	40532	178576	90409323
Intentional dose omission	37.52	12.22	43	40505	17740	90570159
Ill-defined disorder	37.32	12.22	18	40530	184873	90403026
Respiratory syncytial virus test positive	37.32	12.22	15	40533	1043	90586856
Extrapyramidal disorder	37.10	12.22	41	40507	16262	90571637
Rheumatoid arthritis	36.99	12.22	66	40482	362548	90225351
Areflexia	36.84	12.22	22	40526	3631	90584268
Sleep apnoea syndrome	36.43	12.22	57	40491	31690	90556209
Neuroleptic malignant syndrome	36.15	12.22	39	40509	15057	90572842
Fall	35.91	12.22	351	40197	481459	90106440
Mental disorder	35.67	12.22	57	40491	32261	90555638
Mitral valve replacement	35.67	12.22	12	40536	503	90587396
Anger	35.62	12.22	37	40511	13683	90574216
Insomnia	35.45	12.22	263	40285	333211	90254688
Somnambulism	34.86	12.22	26	40522	6202	90581697
Injection site mass	34.64	12.22	46	40502	22044	90565855
Hallucination, auditory	34.34	12.22	39	40509	15936	90571963
Bipolar disorder	34.33	12.22	30	40518	8955	90578944
Anoxia	34.32	12.22	10	40538	259	90587640
Pulmonary fibrosis	34.17	12.22	4	40544	107499	90480400
Hypersensitivity	33.99	12.22	98	40450	454579	90133320
Maternal exposure during pregnancy	33.70	12.22	69	40479	359994	90227905
Hyperhidrosis	33.33	12.22	135	40413	136170	90451729
Respiratory arrest	33.05	12.22	56	40492	33255	90554644
Pupillary reflex impaired	32.83	12.22	18	40530	2527	90585372
Migraine	32.74	12.22	170	40378	190222	90397677
Therapeutic product effect decreased	32.58	12.22	46	40502	277525	90310374
Major depression	31.48	12.22	30	40518	10005	90577894
Emotional disorder	31.20	12.22	36	40512	14961	90572938
Hypothermia	30.10	12.22	36	40512	15539	90572360
Impaired quality of life	30.03	12.22	44	40504	23100	90564799
Neutropenia	29.79	12.22	34	40514	224870	90363029
Alcoholism	29.68	12.22	15	40533	1785	90586114
Total cholesterol/HDL ratio abnormal	29.63	12.22	7	40541	77	90587822
Device expulsion	29.59	12.22	60	40488	40826	90547073
Panic disorder	29.45	12.22	18	40530	3097	90584802
Joint range of motion decreased	29.27	12.22	12	40536	135631	90452268
Multiple sclerosis	29.22	12.22	48	40500	27792	90560107
Foreign body in reproductive tract	29.21	12.22	13	40535	1164	90586735
Hypercholesterolaemia	29.16	12.22	5	40543	100887	90487012
Hospitalisation	29.07	12.22	124	40424	127976	90459923
Generalised anxiety disorder	28.89	12.22	17	40531	2730	90585169
Therapy interrupted	28.79	12.22	67	40481	50041	90537858
Inappropriate schedule of product administration	28.69	12.22	138	40410	149795	90438104
Post-traumatic stress disorder	28.53	12.22	24	40524	6804	90581095
Stiff person syndrome	28.34	12.22	10	40538	484	90587415
Blood cholesterol increased	28.04	12.22	31	40517	207981	90379918
Plasma cell mastitis	27.94	12.22	6	40542	41	90587858
Anaemia	27.87	12.22	74	40474	352728	90235171
Irritable bowel syndrome	27.87	12.22	31	40517	207417	90380482
Product use in unapproved indication	27.54	12.22	250	40298	335986	90251913
Musculoskeletal pain	27.20	12.22	22	40526	171229	90416670
Pancytopenia	27.00	12.22	10	40538	120253	90467646
Peripheral venous disease	26.98	12.22	3	40545	83918	90503981
Gastrointestinal disorder	26.82	12.22	46	40502	256641	90331258
Irritability	26.60	12.22	53	40495	35609	90552290
Pyrexia	26.44	12.22	180	40368	660305	89927594
Sporotrichosis	26.39	12.22	6	40542	55	90587844
Poisoning	25.90	12.22	33	40515	15184	90572715
Grip strength decreased	25.86	12.22	5	40543	92571	90495328
Hallucination, tactile	25.56	12.22	9	40539	433	90587466
Aortic valve replacement	25.23	12.22	11	40537	938	90586961
Mood swings	24.92	12.22	38	40510	20664	90567235
Neurodermatitis	24.81	12.22	16	40532	3022	90584877
Secondary hypertension	24.76	12.22	8	40540	295	90587604
Nausea	24.05	12.22	658	39890	1109658	89478241
Bruxism	23.94	12.22	18	40530	4345	90583554
Generalised tonic-clonic seizure	23.82	12.22	50	40498	34853	90553046
False positive investigation result	23.74	12.22	10	40538	783	90587116
Sleep disorder due to a general medical condition	23.74	12.22	58	40490	44680	90543219
Intentional self-injury	23.59	12.22	45	40503	29289	90558610
Seizure	23.34	12.22	132	40416	152497	90435402
Social avoidant behaviour	23.12	12.22	16	40532	3397	90584502
Drug interaction	22.86	12.22	206	40342	276247	90311652
Skin exfoliation	22.28	12.22	74	40474	67839	90520060
Initial insomnia	22.20	12.22	24	40524	9286	90578613
Affective disorder	22.02	12.22	22	40526	7771	90580128
Red blood cell sedimentation rate increased	21.97	12.22	5	40543	82590	90505309
Wheezing	21.94	12.22	46	40502	238034	90349865
Tachyphrenia	21.83	12.22	12	40536	1694	90586205
Blood bicarbonate abnormal	21.78	12.22	5	40543	48	90587851
Liver disorder	21.31	12.22	14	40534	121255	90466644
Diabetic neuropathy	21.04	12.22	17	40531	4557	90583342
Autonomic nervous system imbalance	20.66	12.22	15	40533	3435	90584464
Euphoric mood	20.54	12.22	18	40530	5391	90582508
Wound infection	20.51	12.22	11	40537	106391	90481508
Antidepressant discontinuation syndrome	20.39	12.22	6	40542	161	90587738
Treatment noncompliance	20.32	12.22	60	40488	51667	90536232
Crying	20.20	12.22	39	40509	25606	90562293
Complication of device removal	20.19	12.22	19	40529	6236	90581663
Mydriasis	20.14	12.22	29	40519	14983	90572916
Device breakage	20.13	12.22	28	40520	14016	90573883
Abnormal uterine bleeding	19.98	12.22	12	40536	2000	90585899
Rhabdomyolysis	19.70	12.22	59	40489	51197	90536702
Mental status changes	19.67	12.22	54	40494	44625	90543274
Interstitial lung disease	19.58	12.22	5	40543	76400	90511499
Syndactyly	19.49	12.22	8	40540	587	90587312
Headache	19.41	12.22	514	40034	862232	89725667
Therapeutic response unexpected	19.39	12.22	35	40513	21845	90566054
Exposure via ingestion	19.24	12.22	13	40535	2654	90585245
Therapy cessation	19.14	12.22	47	40501	36314	90551585
Flat affect	19.08	12.22	11	40537	1700	90586199
Oedema	19.05	12.22	38	40510	200257	90387642
Parkinsonism	18.62	12.22	27	40521	14038	90573861
Mania	18.54	12.22	27	40521	14097	90573802
Ovarian granulosa cell tumour	18.42	12.22	4	40544	29	90587870
Lung disorder	18.42	12.22	24	40524	149859	90438040
Nephrolithiasis	18.40	12.22	56	40492	49029	90538870
Nightmare	18.30	12.22	34	40514	21691	90566208
Psychotic disorder	18.21	12.22	42	40506	31188	90556711
Epilepsy	18.18	12.22	7	40541	82199	90505700
Exposure during pregnancy	18.07	12.22	51	40497	238359	90349540
Skin discomfort	17.90	12.22	11	40537	1910	90585989
Malignant neoplasm progression	17.90	12.22	13	40535	106857	90481042
Exposure via skin contact	17.88	12.22	23	40525	10682	90577217
Emotional distress	17.85	12.22	46	40502	36616	90551283
Myofascial pain syndrome	17.84	12.22	13	40535	2994	90584905
Cardiogenic shock	17.81	12.22	36	40512	24432	90563467
Depressed level of consciousness	17.71	12.22	72	40476	72712	90515187
Injection site swelling	17.70	12.22	63	40485	59776	90528123
Dystonia	17.65	12.22	29	40519	16790	90571109
Cleft lip and palate	17.65	12.22	8	40540	748	90587151
Impaired gastric emptying	17.56	12.22	25	40523	12784	90575115
Delusion	17.50	12.22	26	40522	13814	90574085
Gait inability	17.44	12.22	24	40524	146432	90441467
Hepatitis	17.43	12.22	5	40543	70734	90517165
Abdominal discomfort	17.18	12.22	134	40414	477194	90110705
Dental restoration failure	17.17	12.22	9	40539	1155	90586744
Sedation	17.17	12.22	54	40494	48117	90539782
Akathisia	17.13	12.22	23	40525	11136	90576763
Bradykinesia	17.07	12.22	18	40530	6770	90581129
Live birth	17.06	12.22	7	40541	79100	90508799
Therapeutic response shortened	17.06	12.22	34	40514	22845	90565054
Haemoglobin decreased	16.93	12.22	29	40519	161927	90425972
Dyskinesia	16.93	12.22	45	40503	36489	90551410
Cardiac arrest	16.87	12.22	92	40456	104843	90483056
Anhedonia	16.70	12.22	23	40525	11408	90576491
Perinatal depression	16.67	12.22	8	40540	851	90587048
Injury	16.65	12.22	40	40508	197309	90390590
Laryngeal granuloma	16.53	12.22	3	40545	7	90587892
Type 2 diabetes mellitus	16.52	12.22	42	40506	203202	90384697
Accidental exposure to product	16.50	12.22	49	40499	42317	90545582
Agoraphobia	16.47	12.22	7	40541	561	90587338
Dyspareunia	16.42	12.22	12	40536	2774	90585125
Mucosal inflammation	16.34	12.22	3	40545	57622	90530277
Cerebellar infarction	16.28	12.22	11	40537	2247	90585652
Autoimmune disorder	16.21	12.22	7	40541	76737	90511162
Acute respiratory failure	16.12	12.22	49	40499	42869	90545030
Needle issue	15.96	12.22	25	40523	13909	90573990
Insurance issue	15.93	12.22	22	40526	10936	90576963
Mood altered	15.93	12.22	28	40520	17116	90570783
Asthma	15.89	12.22	172	40376	241988	90345911
Impulse-control disorder	15.66	12.22	8	40540	974	90586925
Prescribed underdose	15.60	12.22	7	40541	75012	90512887
Restlessness	15.55	12.22	43	40505	35677	90552222
Sleep-related eating disorder	15.49	12.22	8	40540	996	90586903
Blepharospasm	15.48	12.22	3	40545	55442	90532457
Vitamin D deficiency	15.45	12.22	28	40520	17528	90570371
Hypertensive urgency	15.20	12.22	7	40541	679	90587220
Hallucination	15.07	12.22	64	40484	65895	90522004
Renal impairment	15.00	12.22	15	40533	105406	90482493
Drug effect less than expected	14.95	12.22	16	40532	6122	90581777
Prescribed overdose	14.94	12.22	13	40535	97612	90490287
Nail disorder	14.88	12.22	4	40544	59063	90528836
Hypersomnia	14.87	12.22	31	40517	21500	90566399
Narcolepsy	14.86	12.22	9	40539	1523	90586376
Blood pressure orthostatic	14.85	12.22	4	40544	77	90587822
Vertigo	14.63	12.22	66	40482	69745	90518154
Medication error	14.57	12.22	10	40538	84642	90503257
Sensation of foreign body	14.47	12.22	16	40532	6350	90581549
Psychomotor retardation	14.42	12.22	14	40534	4775	90583124
Psoriasis	14.26	12.22	114	40434	147640	90440259
Lethargy	14.22	12.22	61	40487	63078	90524821
Reversible cerebral vasoconstriction syndrome	14.21	12.22	13	40535	4117	90583782
Spinal operation	14.13	12.22	20	40528	10176	90577723
Attention deficit hyperactivity disorder	14.07	12.22	13	40535	4171	90583728
Osteoarthritis	14.01	12.22	43	40505	195687	90392212
Hypervigilance	13.98	12.22	6	40542	492	90587407
Restless legs syndrome	13.97	12.22	31	40517	22439	90565460
Embedded device	13.90	12.22	13	40535	4235	90583664
Flushing	13.83	12.22	77	40471	88414	90499485
Abnormal behaviour	13.82	12.22	31	40517	22597	90565302
Muscle necrosis	13.82	12.22	7	40541	837	90587062
Sciatica	13.77	12.22	15	40533	101367	90486532
Pleural effusion	13.69	12.22	18	40530	111973	90475926
Dermatillomania	13.68	12.22	5	40543	268	90587631
Product use issue	13.62	12.22	89	40459	329830	90258069
Snoring	13.62	12.22	14	40534	5112	90582787
Hyperkalaemia	13.61	12.22	6	40542	64958	90522941
Muscle twitching	13.51	12.22	32	40516	24170	90563729
Tension	13.48	12.22	12	40536	3670	90584229
Hospice care	13.39	12.22	19	40529	9685	90578214
Infection	13.33	12.22	101	40447	361993	90225906
Musculoskeletal stiffness	13.28	12.22	78	40470	296454	90291445
Alcohol withdrawal syndrome	13.22	12.22	7	40541	917	90586982
Cardiac death	13.03	12.22	6	40542	582	90587317
Disease progression	13.01	12.22	32	40516	156583	90431316
Injection site reaction	13.00	12.22	78	40470	92002	90495897
Hepatic cirrhosis	13	12.22	6	40542	63247	90524652
Abdominal pain	12.91	12.22	114	40434	395607	90192292
Muscle rigidity	12.82	12.22	23	40525	14286	90573613
Sleep deficit	12.73	12.22	7	40541	989	90586910
Stress cardiomyopathy	12.65	12.22	22	40526	13333	90574566
Product preparation error	12.58	12.22	19	40529	10242	90577657
Presbyopia	12.54	12.22	6	40542	634	90587265
Long QT syndrome	12.53	12.22	12	40536	4025	90583874
Accidental death	12.48	12.22	9	40539	2039	90585860
Urinary tract infection	12.46	12.22	199	40349	305433	90282466
Balance disorder	12.31	12.22	80	40468	97000	90490899
Injection site induration	12.29	12.22	19	40529	10449	90577450
Chills	12.28	12.22	101	40447	131880	90456019
Vision blurred	12.27	12.22	88	40460	110205	90477694
Thunderclap headache	12.23	12.22	5	40543	363	90587536

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Serotonin syndrome	224.29	15.67	125	13391	25720	42582099
Completed suicide	203.41	15.67	198	13318	96267	42511552
Sedation	162.70	15.67	108	13408	30367	42577452
Suicidal ideation	120.81	15.67	109	13407	48052	42559767
Dissociation	108.44	15.67	42	13474	3756	42604063
Anxiety	105.53	15.67	157	13359	118403	42489416
Irritability	91.65	15.67	74	13442	28054	42579765
Tardive dyskinesia	87.17	15.67	43	13473	6881	42600938
Agitation	74.88	15.67	97	13419	64217	42543602
Depression	61.14	15.67	119	13397	111244	42496575
Aggression	58.38	15.67	71	13445	44092	42563727
Product administration interrupted	51.33	15.67	27	13489	4939	42602880
Tremor	50.07	15.67	101	13415	96828	42510991
Drug abuse	42.48	15.67	99	13417	104672	42503147
Product dose omission issue	41.35	15.67	125	13391	154240	42453579
Obesity	40.72	15.67	37	13479	16422	42591397
Insomnia	38.73	15.67	103	13413	118150	42489669
Neuroleptic malignant syndrome	37.67	15.67	40	13476	21432	42586387
Toxicity to various agents	34.58	15.67	154	13362	228982	42378837
Withdrawal syndrome	32.29	15.67	31	13485	14744	42593075
General physical health deterioration	31.73	15.67	5	13511	151241	42456578
Febrile neutropenia	31.25	15.67	10	13506	185693	42422126
Electrocardiogram QRS complex prolonged	29.51	15.67	20	13496	5803	42602016
Akathisia	28.85	15.67	25	13491	10426	42597393
Suspected suicide	28.37	15.67	20	13496	6179	42601640
Muscle necrosis	27.86	15.67	11	13505	1034	42606785
Orthostatic hypotension	26.42	15.67	40	13476	30530	42577289
Seizure	26.25	15.67	91	13425	120470	42487349
Anger	25.99	15.67	26	13490	12992	42594827
Thrombocytopenia	25.97	15.67	14	13502	190265	42417554
Drug withdrawal syndrome	25.82	15.67	33	13483	21516	42586303
Poisoning deliberate	25.49	15.67	23	13493	10111	42597708
Wrong patient	25.35	15.67	9	13507	630	42607189
Post-traumatic stress disorder	25.26	15.67	13	13503	2272	42605547
Orthostatic tremor	24.56	15.67	4	13512	6	42607813
Behaviour disorder	23.90	15.67	19	13497	7035	42600784
Panic attack	23.80	15.67	23	13493	11022	42596797
Bipolar disorder	23.60	15.67	15	13501	3907	42603912
Pneumonia	23.57	15.67	63	13453	422086	42185733
Intentional overdose	23.48	15.67	51	13465	51405	42556414
Hypoparathyroidism	20.63	15.67	8	13508	717	42607102
Therapy interrupted	20.50	15.67	30	13486	22220	42585599
Anaemia	20.45	15.67	36	13480	280242	42327577
Pancytopenia	20.41	15.67	6	13510	117737	42490082
Acute kidney injury	20.35	15.67	55	13461	367282	42240537
Injection site reaction	20.31	15.67	25	13491	15696	42592123
Dermatitis atopic	19.82	15.67	22	13494	12382	42595437
Feeling abnormal	19.10	15.67	57	13459	69729	42538090
Lens dislocation	18.67	15.67	5	13511	135	42607684
Neonatal respiratory distress	18.42	15.67	8	13508	957	42606862
Renal impairment	18.41	15.67	6	13510	110222	42497597
Hypotonia neonatal	18.03	15.67	9	13507	1475	42606344
Stress cardiomyopathy	17.63	15.67	11	13505	2774	42605045
Parkinsonism	17.25	15.67	19	13497	10604	42597215
Alcoholism	17.12	15.67	11	13505	2919	42604900
Neutropenia	17.04	15.67	23	13493	199408	42408411
Coma	16.85	15.67	46	13470	53508	42554311
Nightmare	16.54	15.67	29	13487	24983	42582836
Disinhibition	16.52	15.67	12	13504	3883	42603936
Microvascular coronary artery disease	16.12	15.67	4	13512	79	42607740
Drug interaction	15.70	15.67	141	13375	266858	42340961

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1032.75	12.23	808	41930	241573	110304988
Serotonin syndrome	551.00	12.23	321	42417	58832	110487729
Suicidal ideation	261.53	12.23	246	42492	93691	110452870
Toxicity to various agents	178.10	12.23	496	42242	480059	110066502
Anxiety	160.49	12.23	388	42350	344690	110201871
Dissociation	140.66	12.23	71	42667	9771	110536790
Depression	126.84	12.23	337	42401	316998	110229563
Product dose omission issue	121.86	12.23	335	42403	321447	110225114
Suspected suicide	119.41	12.23	74	42664	15125	110531436
Dermatitis atopic	118.87	12.23	90	42648	25451	110521110
Agitation	110.35	12.23	174	42564	112877	110433684
Sedation	106.48	12.23	133	42605	69550	110477011
Intentional overdose	105.34	12.23	186	42552	132315	110414246
Product administration interrupted	101.66	12.23	60	42678	11232	110535329
Tremor	99.96	12.23	233	42505	201999	110344562
Withdrawal syndrome	98.60	12.23	88	42650	31292	110515269
General physical health deterioration	94.41	12.23	24	42714	425271	110121290
Injection site pain	86.83	12.23	204	42534	177718	110368843
Irritability	75.84	12.23	93	42645	47716	110498845
Tardive dyskinesia	72.53	12.23	52	42686	13527	110533034
Synovitis	72.43	12.23	10	42728	274082	110272479
Neuroleptic malignant syndrome	72.23	12.23	77	42661	33982	110512579
Febrile neutropenia	70.04	12.23	18	42720	316749	110229812
Hand deformity	68.32	12.23	4	42734	218502	110328059
Glossodynia	66.66	12.23	5	42733	221999	110324562
Drug abuse	62.45	12.23	180	42558	177231	110369330
Panic attack	62.38	12.23	66	42672	28874	110517687
Drug withdrawal syndrome	61.94	12.23	75	42663	37979	110508582
Infusion related reaction	60.73	12.23	36	42702	381126	110165435
Thrombocytopenia	59.87	12.23	30	42708	348855	110197706
Lower respiratory tract infection	59.44	12.23	11	42727	243095	110303466
Drug intolerance	58.54	12.23	43	42695	406469	110140092
Wound	56.48	12.23	11	42727	234426	110312135
Overdose	55.12	12.23	207	42531	233587	110312974
Anaemia	54.86	12.23	79	42659	547007	109999554
Impaired healing	54.84	12.23	6	42732	196711	110349850
Complication of device insertion	54.59	12.23	37	42701	8801	110537760
Suicide attempt	53.10	12.23	121	42617	103273	110443288
Insomnia	52.19	12.23	276	42462	360314	110186247
Systemic lupus erythematosus	51.54	12.23	17	42721	254321	110292240
Bezoar	51.44	12.23	27	42711	4027	110542534
Contraindicated product administered	51.36	12.23	16	42722	248251	110298310
Arthropathy	50.42	12.23	24	42714	287498	110259063
Pancytopenia	50.15	12.23	10	42728	209603	110336958
Helicobacter infection	49.57	12.23	6	42732	181871	110364690
Depressed mood	49.12	12.23	86	42652	60723	110485838
Corneal reflex decreased	48.98	12.23	15	42723	538	110546023
Neutropenia	48.49	12.23	44	42694	374576	110171985
Akathisia	47.92	12.23	45	42693	17068	110529493
Treatment failure	47.31	12.23	24	42714	277210	110269351
Cardio-respiratory arrest	47.18	12.23	124	42614	115712	110430849
Feeling abnormal	45.95	12.23	164	42574	180547	110366014
Hepatic enzyme increased	44.83	12.23	35	42703	320857	110225704
Folliculitis	44.56	12.23	6	42732	167647	110378914
Respiratory arrest	43.94	12.23	80	42658	58219	110488342
C-reactive protein increased	43.39	12.23	15	42723	217904	110328657
Pupillary reflex impaired	43.29	12.23	24	42714	3991	110542570
Muscle injury	42.75	12.23	3	42735	140804	110405757
Surgery	42.29	12.23	65	42673	41218	110505343
Muscle necrosis	41.29	12.23	18	42720	1779	110544782
Endocarditis enterococcal	41.08	12.23	12	42726	365	110546196
Anger	40.35	12.23	43	42695	18964	110527597
Stomatitis	39.65	12.23	28	42710	270214	110276347
Alcoholism	39.53	12.23	22	42716	3685	110542876
Injection site mass	39.23	12.23	48	42690	24565	110521996
Renal impairment	37.47	12.23	13	42725	188432	110358129
Pyrexia	37.11	12.23	200	42538	898065	109648496
Swelling	36.85	12.23	49	42689	350992	110195569
Generalised anxiety disorder	36.67	12.23	19	42719	2760	110543801
Liver injury	36.34	12.23	7	42731	150406	110396155
Behaviour disorder	36.30	12.23	30	42708	9617	110536944
Impaired quality of life	36.14	12.23	51	42687	29966	110516595
Seizure	35.96	12.23	175	42563	221010	110325551
Drug screen false positive	35.70	12.23	15	42723	1354	110545207
Inflammation	35.64	12.23	15	42723	193223	110353338
Mental disorder	35.49	12.23	58	42680	38733	110507828
Drug-induced liver injury	35.21	12.23	3	42735	120064	110426497
Mitral valve replacement	35.09	12.23	12	42726	614	110545947
Emotional disorder	35.08	12.23	37	42701	16123	110530438
Mental status changes	34.64	12.23	85	42653	76037	110470524
Disturbance in attention	34.58	12.23	75	42663	61920	110484641
Respiratory syncytial virus test positive	34.44	12.23	15	42723	1479	110545082
Poisoning	34.38	12.23	49	42689	29056	110517505
Joint swelling	34.37	12.23	75	42663	442770	110103791
Delusion	34.15	12.23	44	42694	23711	110522850
Electrocardiogram QRS complex prolonged	34.10	12.23	33	42705	12988	110533573
Blister	34.09	12.23	23	42715	227353	110319208
Major depression	31.81	12.23	29	42709	10592	110535969
Parkinsonism	31.74	12.23	41	42697	22146	110524415
Bursitis	31.48	12.23	6	42732	129912	110416649
Fall	31.46	12.23	364	42374	603118	109943443
Drug interaction	30.84	12.23	312	42426	499871	110046690
Anoxia	30.83	12.23	10	42728	434	110546127
Total cholesterol/HDL ratio abnormal	30.57	12.23	7	42731	78	110546483
Somnolence	30.40	12.23	208	42530	297241	110249320
Intentional self-injury	30.31	12.23	53	42685	37376	110509185
Mydriasis	30.23	12.23	40	42698	22117	110524444
Foreign body in reproductive tract	29.92	12.23	12	42726	962	110545599
Bipolar disorder	29.77	12.23	26	42712	8981	110537580
Hyperhidrosis	29.59	12.23	147	42591	187151	110359410
Hyperkalaemia	29.46	12.23	8	42730	135788	110410773
Aggression	28.97	12.23	68	42670	59142	110487419
Extrapyramidal disorder	28.93	12.23	45	42693	28822	110517739
Stress cardiomyopathy	28.78	12.23	33	42705	15773	110530788
Post-traumatic stress disorder	27.97	12.23	22	42716	6574	110539987
Hypertensive urgency	27.93	12.23	12	42726	1145	110545416
Sleep disorder due to general medical condition, insomnia type	27.55	12.23	4	42734	105639	110440922
Areflexia	27.47	12.23	22	42716	6747	110539814
COVID-19	27.23	12.23	175	42563	244885	110301676
Interstitial lung disease	27.03	12.23	10	42728	139324	110407237
Stiff person syndrome	26.95	12.23	10	42728	650	110545911
Product dose omission in error	26.91	12.23	39	42699	23473	110523088
Device expulsion	26.66	12.23	45	42693	30846	110515715
Somnambulism	26.38	12.23	21	42717	6384	110540177
Muscle twitching	26.36	12.23	44	42694	29891	110516670
Hallucination, auditory	26.25	12.23	41	42697	26356	110520205
Pre-existing condition improved	26.04	12.23	21	42717	6505	110540056
Rheumatoid arthritis	25.58	12.23	48	42690	299565	110246996
Nightmare	25.17	12.23	50	42688	38813	110507748
Dry skin	25.08	12.23	95	42643	107558	110439003
Panic disorder	25.05	12.23	16	42722	3445	110543116
Initial insomnia	24.74	12.23	25	42713	10364	110536197
Ovarian granulosa cell tumour	24.72	12.23	5	42733	29	110546532
Ill-defined disorder	24.69	12.23	15	42723	156838	110389723
Nausea	24.67	12.23	638	42100	1235052	109311509
Malignant neoplasm progression	24.42	12.23	19	42719	174548	110372013
Musculoskeletal pain	24.26	12.23	21	42717	183002	110363559
Mucosal inflammation	24.25	12.23	4	42734	96137	110450424
Therapy interrupted	24.14	12.23	57	42681	49765	110496796
Disinhibition	23.96	12.23	15	42723	3119	110543442
Plasma cell mastitis	23.91	12.23	5	42733	35	110546526
Illness	23.88	12.23	78	42660	82093	110464468
Device breakage	23.82	12.23	28	42710	13741	110532820
Product preparation error	23.78	12.23	25	42713	10854	110535707
Attention deficit hyperactivity disorder	23.53	12.23	17	42721	4474	110542087
Liver disorder	23.25	12.23	13	42725	142230	110404331
Vision blurred	23.09	12.23	105	42633	128917	110417644
Mobility decreased	23.06	12.23	35	42703	237387	110309174
Pleural effusion	22.82	12.23	21	42717	177688	110368873
Treatment noncompliance	22.77	12.23	71	42667	72919	110473642
Needle issue	22.50	12.23	31	42707	17809	110528752
Peripheral venous disease	22.37	12.23	3	42735	84114	110462447
Fatigue	22.03	12.23	620	42118	1215338	109331223
Injection site reaction	21.91	12.23	80	42658	88990	110457571
Disease progression	21.80	12.23	38	42700	243996	110302565
Flat affect	21.74	12.23	13	42725	2492	110544069
Antidepressant discontinuation syndrome	21.63	12.23	6	42732	151	110546410
Therapy cessation	21.38	12.23	51	42687	44806	110501755
Feeling of despair	21.34	12.23	15	42723	3783	110542778
Psychotic disorder	21.21	12.23	55	42683	50882	110495679
Aortic valve replacement	21.12	12.23	11	42727	1615	110544946
Dermatillomania	20.98	12.23	7	42731	332	110546229
Complication of device removal	20.88	12.23	16	42722	4604	110541957
Social avoidant behaviour	20.83	12.23	17	42721	5352	110541209
Rhabdomyolysis	20.82	12.23	97	42641	120304	110426257
Secondary hypertension	20.52	12.23	8	42730	595	110545966
Hypercholesterolaemia	20.37	12.23	5	42733	90832	110455729
Joint range of motion decreased	20.10	12.23	11	42727	121821	110424740
Tachyphrenia	19.86	12.23	12	42726	2344	110544217
Hospitalisation	19.85	12.23	108	42630	142385	110404176
Hypothermia	19.70	12.23	36	42702	26266	110520295
Restlessness	19.69	12.23	57	42681	56202	110490359
False positive investigation result	19.62	12.23	10	42728	1404	110545157
Therapeutic response unexpected	19.61	12.23	34	42704	23809	110522752
Hallucination, tactile	19.59	12.23	9	42729	1006	110545555
Orthostatic tremor	19.52	12.23	4	42734	25	110546536
Hypersensitivity	19.51	12.23	85	42653	403913	110142648
Headache	19.47	12.23	462	42276	881915	109664646
Injection site induration	19.45	12.23	23	42715	11360	110535201
Oedema	19.40	12.23	32	42706	209944	110336617
Haemoglobin decreased	19.38	12.23	42	42696	248685	110297876
Hallucination	19.24	12.23	84	42654	101348	110445213
Mania	18.89	12.23	31	42707	20765	110525796
Euphoric mood	18.79	12.23	20	42718	8807	110537754
Therapeutic product effect decreased	18.43	12.23	42	42696	244274	110302287
Wheezing	18.36	12.23	45	42693	255185	110291376
Intentional dose omission	18.33	12.23	30	42708	20050	110526511
Cardiogenic shock	18.09	12.23	56	42682	57282	110489279
Impulse-control disorder	18.04	12.23	11	42727	2183	110544378
Hepatic function abnormal	18.02	12.23	6	42732	89289	110457272
Accidental exposure to product	17.83	12.23	51	42687	49957	110496604
Anticholinergic syndrome	17.56	12.23	14	42724	4266	110542295
Sleep disorder due to a general medical condition	17.48	12.23	52	42686	52060	110494501
Neurodermatitis	17.45	12.23	12	42726	2920	110543641
Ascites	17.44	12.23	7	42731	92801	110453760
Sleep deficit	17.39	12.23	10	42728	1782	110544779
Platelet count decreased	17.07	12.23	40	42698	230403	110316158
Blood bicarbonate abnormal	17.06	12.23	5	42733	154	110546407
Laryngeal granuloma	16.97	12.23	3	42735	7	110546554
Diabetic neuropathy	16.96	12.23	17	42721	6982	110539579
Grip strength decreased	16.87	12.23	5	42733	80169	110466392
Hypersomnia	16.86	12.23	35	42703	28026	110518535
Stress	16.86	12.23	83	42655	105265	110441296
Mood swings	16.80	12.23	31	42707	22781	110523780
Impaired gastric emptying	16.64	12.23	23	42715	13252	110533309
Crying	16.63	12.23	33	42705	25595	110520966
Epilepsy	16.60	12.23	9	42729	100200	110446361
Hepatitis	16.59	12.23	7	42731	90047	110456514
Accidental exposure to product by child	16.52	12.23	12	42726	3186	110543375
Septic shock	16.50	12.23	22	42716	157506	110389055
Injection site swelling	16.49	12.23	57	42681	61733	110484828
Myofascial pain syndrome	16.44	12.23	11	42727	2562	110543999
Gastrointestinal disorder	16.37	12.23	44	42694	241908	110304653
Alopecia	16.26	12.23	79	42659	364674	110181887
Depressed level of consciousness	16.25	12.23	86	42652	112192	110434369
Emotional distress	16.24	12.23	46	42692	44801	110501760
Hospice care	16.22	12.23	22	42716	12451	110534110
Lens dislocation	16.15	12.23	5	42733	186	110546375
Irritable bowel syndrome	16.14	12.23	24	42714	164191	110382370
Embedded device	16.14	12.23	13	42725	4020	110542541
Ideas of reference	16.03	12.23	5	42733	191	110546370
Poisoning deliberate	16.01	12.23	33	42705	26298	110520263
Exposure via ingestion	15.90	12.23	14	42724	4886	110541675
Agoraphobia	15.89	12.23	7	42731	709	110545852
Skin discomfort	15.88	12.23	10	42728	2100	110544461
Dizziness	15.82	12.23	367	42371	697826	109848735
Presbyopia	15.68	12.23	7	42731	732	110545829
Therapeutic response shortened	15.60	12.23	35	42703	29548	110517013
Live birth	15.24	12.23	4	42734	69480	110477081
Lung disorder	15.22	12.23	29	42709	180018	110366543
Migraine	15.19	12.23	116	42622	171536	110375025
Affective disorder	14.89	12.23	20	42718	11221	110535340
Coma	14.87	12.23	87	42651	117782	110428779
Pneumonia	14.82	12.23	244	42494	876470	109670091
Maternal exposure during pregnancy	14.63	12.23	50	42688	254833	110291728
Antisocial behaviour	14.60	12.23	7	42731	861	110545700
Increased appetite	14.53	12.23	23	42715	14954	110531607
Muscle rigidity	14.47	12.23	30	42708	24001	110522560
Death	14.22	12.23	362	42376	698507	109848054
Generalised tonic-clonic seizure	14.20	12.23	50	42688	54630	110491931
Dystonia	14.14	12.23	31	42707	25774	110520787
Drug dependence	14.10	12.23	47	42691	49973	110496588
Abnormal behaviour	14.10	12.23	40	42698	38999	110507562
Respiratory disorder	14.05	12.23	5	42733	71377	110475184
Device dislocation	14.00	12.23	35	42703	31669	110514892
Restless legs syndrome	13.97	12.23	30	42708	24596	110521965
Clonus	13.89	12.23	17	42721	8699	110537862
Exposure via skin contact	13.88	12.23	21	42717	13126	110533435
Injection site abscess	13.84	12.23	9	42729	1997	110544564
Tension	13.54	12.23	13	42725	5065	110541496
Ankle fracture	13.44	12.23	26	42712	19793	110526768
Hypoparathyroidism	13.43	12.23	8	42730	1522	110545039
Dopamine transporter scintigraphy abnormal	13.40	12.23	3	42735	30	110546531
Pupillary deformity	13.40	12.23	3	42735	30	110546531
Nail disorder	13.36	12.23	3	42735	57932	110488629
Gait inability	13.34	12.23	20	42718	136356	110410205
Bone marrow failure	13.34	12.23	3	42735	57845	110488716
Dyskinesia	13.33	12.23	47	42691	51399	110495162
Hyperphagia	13.32	12.23	11	42727	3520	110543041
Hepatotoxicity	13.26	12.23	4	42734	63396	110483165
Hypervigilance	13.23	12.23	6	42732	651	110545910
Melaena	13.23	12.23	5	42733	68752	110477809
Liver function test increased	13.21	12.23	9	42729	88539	110458022
Psoriasis	13.18	12.23	96	42642	139897	110406664
Multiple sclerosis	13.10	12.23	30	42708	25668	110520893
Liquid product physical issue	13.10	12.23	8	42730	1592	110544969
Red blood cell sedimentation rate increased	13.02	12.23	7	42731	78295	110468266
Obsessive-compulsive disorder	12.99	12.23	15	42723	7226	110539335
Gestational hypertension	12.96	12.23	9	42729	2225	110544336
Dyspareunia	12.91	12.23	9	42729	2240	110544321
Expired product administered	12.89	12.23	16	42722	8304	110538257
Hepatic cirrhosis	12.87	12.23	5	42733	67621	110478940
Wound infection	12.86	12.23	11	42727	96454	110450107
Activation syndrome	12.79	12.23	5	42733	375	110546186
Dental restoration failure	12.76	12.23	7	42731	1140	110545421
Gynaecomastia	12.74	12.23	17	42721	9473	110537088
Agranulocytosis	12.73	12.23	4	42734	61756	110484805
Anhedonia	12.69	12.23	22	42716	15406	110531155
Radioisotope scan abnormal	12.57	12.23	6	42732	731	110545830
Blepharospasm	12.34	12.23	3	42735	54848	110491713
Spinal operation	12.27	12.23	18	42720	10954	110535607

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05BE01	NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Azaspirodecanedione derivatives
CHEBI has role	CHEBI:35469	antidepressant
CHEBI has role	CHEBI:35474	anxiolytic drug
CHEBI has role	CHEBI:35476	antipsychotic agent
CHEBI has role	CHEBI:35717	sedative
CHEBI has role	CHEBI:35941	serotonergic agonist
CHEBI has role	CHEBI:48407	antiparkinson drug
CHEBI has role	CHEBI:55324	gastrointestinal drug
CHEBI has role	CHEBI:76779	EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014151	Anti-Anxiety Agents
MeSH PA	D017366	Serotonin Receptor Agonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018490	Serotonin Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Generalized anxiety disorder	indication	21897009	DOID:14320
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.51	Basic
pKa2	2.23	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN	PARTIAL AGONIST	EC50	7.25	WOMBAT-PK	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	7.32	WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		IC50	5.40	CHEMBL
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		Ki	5.13	WOMBAT-PK
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	6.60	WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.41	WOMBAT-PK
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	6.04	WOMBAT-PK
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	6.08	CHEMBL
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	6.44	WOMBAT-PK
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.18	CHEMBL
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN		Ki	7	WOMBAT-PK
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	6.28	DRUG MATRIX
Solute carrier family 22 member 2	Transporter	O15244	S22A2_HUMAN		IC50	4.92	CHEMBL
Multidrug and toxin extrusion protein 1	Transporter	Q96FL8	S47A1_HUMAN		IC50	5.77	CHEMBL
Multidrug and toxin extrusion protein 2	Transporter	Q86VL8	S47A2_HUMAN		IC50	4.34	CHEMBL
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	7.68	WOMBAT-PK
5-hydroxytryptamine receptor 1B	GPCR		5HT1B_RAT		Ki	7.77	CHEMBL
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		IC50	5.47	DRUG MATRIX
D(2) dopamine receptor	GPCR		DRD2_RAT		Ki	6.92	CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		Ki	8.42	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_RAT		Ki	6.32	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor		SGMR1_RAT		Ki	7.32	CHEMBL
5-hydroxytryptamine receptor 7	GPCR		5HT7R_RAT	AGONIST	Ki	6.40	IUPHAR
5-hydroxytryptamine receptor 7	GPCR		5HT7R_MOUSE	ANTAGONIST	Ki	6.40	IUPHAR
D(1A) dopamine receptor	GPCR		DRD1_BOVIN		Ki	5.21	CHEMBL
D(2) dopamine receptor	GPCR		DRD2_BOVIN		Ki	7.36	CHEMBL
5-hydroxytryptamine receptor 2C	GPCR		5HT2C_RAT		IC50	6	CHEMBL
Alpha-1A adrenergic receptor	GPCR		ADA1A_BOVIN		IC50	4.80	CHEMBL
Alpha-2A adrenergic receptor	GPCR		ADA2A_BOVIN		IC50	5	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_BOVIN		Ki	6.75	CHEMBL
Serotonin 1 (5-HT1) receptor	GPCR		5HT1A_RAT 5HT1B_RAT 5HT1D_RAT 5HT1F_RAT		IC50	7.02	CHEMBL
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		IC50	5	CHEMBL
Dopamine receptor	GPCR		DRD1_RAT DRD3_RAT DRD5_RAT DRD4_RAT DRD2_RAT		IC50	6.92	CHEMBL
Adrenergic receptor alpha-1	GPCR		ADA1B_RAT ADA1D_RAT ADA1A_RAT		Ki	6.86	CHEMBL
Serotonin 2 (5-HT2) receptor	GPCR		5HT2C_RAT 5HT2A_RAT 5HT2B_RAT		Ki	6.76	CHEMBL

External reference:

ID	Source
4019646	VUID
N0000147739	NUI
D00702	KEGG_DRUG
33386-08-2	SECONDARY_CAS_RN
1827	RXNORM
C0006462	UMLSCUI
CHEBI:3223	CHEBI
YLX	PDB_CHEM_ID
CHEMBL49	ChEMBL_ID
CHEMBL1200399	ChEMBL_ID
DB00490	DRUGBANK_ID
D002065	MESH_DESCRIPTOR_UI
2477	PUBCHEM_CID
36	IUPHAR_LIGAND_ID
3456	INN_ID
TK65WKS8HL	UNII
37673	MMSL
4308	MMSL
d00182	MMSL
387523009	SNOMEDCT_US
419484002	SNOMEDCT_US
91452003	SNOMEDCT_US
4018813	VANDF
4019646	VANDF
001468	NDDF
004586	NDDF
TK65WKS8HL	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0053	TABLET	5 mg	ORAL	ANDA	28 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0054	TABLET	10 mg	ORAL	ANDA	28 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-1003	TABLET	15 mg	ORAL	ANDA	28 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-5200	TABLET	30 mg	ORAL	ANDA	28 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1140	TABLET	5 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1150	TABLET	10 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1165	TABLET	15 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1175	TABLET	30 mg	ORAL	ANDA	27 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7689	TABLET	15 mg	ORAL	ANDA	28 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7714	TABLET	5 mg	ORAL	ANDA	28 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7718	TABLET	10 mg	ORAL	ANDA	28 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8434	TABLET	7.50 mg	ORAL	ANDA	22 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8527	TABLET	30 mg	ORAL	ANDA	28 sections
Buspirone hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6899	TABLET	15 mg	ORAL	ANDA	22 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7121	TABLET	10 mg	ORAL	ANDA	15 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7122	TABLET	5 mg	ORAL	ANDA	15 sections
Buspirone HCl	HUMAN PRESCRIPTION DRUG LABEL	1	10544-176	TABLET	10 mg	ORAL	ANDA	27 sections
Buspirone hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	11788-057	TABLET	5 mg	ORAL	ANDA	15 sections
Buspirone hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	11788-058	TABLET	7.50 mg	ORAL	ANDA	15 sections
Buspirone hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	11788-059	TABLET	10 mg	ORAL	ANDA	15 sections
Buspirone hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	11788-060	TABLET	15 mg	ORAL	ANDA	15 sections
Buspirone hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	11788-061	TABLET	30 mg	ORAL	ANDA	15 sections
BUSPIRONE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-375	TABLET	30 mg	ORAL	ANDA	27 sections
BUSPIRONE HCl	HUMAN PRESCRIPTION DRUG LABEL	1	16590-579	TABLET	15 mg	ORAL	ANDA	27 sections
BUSPIRONE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-600	TABLET	10 mg	ORAL	ANDA	13 sections
BUSPIRONE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-727	TABLET	7.50 mg	ORAL	ANDA	26 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	16729-200	TABLET	5 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	16729-200	TABLET	5 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	16729-201	TABLET	7.50 mg	ORAL	ANDA	29 sections
Buspirone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	16729-201	TABLET	7.50 mg	ORAL	ANDA	29 sections